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  1. The isolated rapid-eye-movement sleep behavior disorder (iRBD) is a prodromal condition of Lewy body disease including Parkinson's disease and dementia with Lewy bodies (DLB). We aim to investigate the longitu...

    Authors: Jung Hwan Shin, Heejung Kim, Yu Kyeong Kim, Eun Jin Yoon, Hyunwoo Nam, Beomseok Jeon and Jee-Young Lee
    Citation: Translational Neurodegeneration 2023 12:27
  2. The clinical utility and safety of sargramostim has previously been reported in cancer, acute radiation syndrome, autoimmune disease, inflammatory conditions, and Alzheimer’s disease. The safety, tolerability,...

    Authors: Katherine E. Olson, Mai M. Abdelmoaty, Krista L. Namminga, Yaman Lu, Helen Obaro, Pamela Santamaria, R. Lee Mosley and Howard E. Gendelman
    Citation: Translational Neurodegeneration 2023 12:26
  3. Authors: Kelsie M. LaBarbera, Yvette I. Sheline, Nicholas J. Izzo, Carla M. Yuede, Lora Waybright, Raymond Yurko, Hannah M. Edwards, Woodrow D. Gardiner, Kaj Blennow, Henrik Zetterberg, Anne Börjesson-Hanson, Roger Morgan, Charles S. Davis, Robert J. Guttendorf, Lon S. Schneider, Steven DeKosky…
    Citation: Translational Neurodegeneration 2023 12:24
  4. Authors: Xavier Sánchez‑Sáez, Isabel Ortuño‑Lizarán, Carla Sánchez‑Castillo, Pedro Lax and Nicolás Cuenca
    Citation: Translational Neurodegeneration 2023 12:22

    The original article was published in Translational Neurodegeneration 2023 12:17

  5. Authors: Nuole Zhu, Miguel Santos-Santos, Ignacio Illán-Gala, Victor Montal, Teresa Estellés, Isabel Barroeta, Miren Altuna, Javier Arranz, Laia Muñoz, Olivia Belbin, Isabel Sala, Maria Belén Sánchez-Saudinós, Andrea Subirana, Laura Videla, Jordi Pegueroles, Rafael Blesa…
    Citation: Translational Neurodegeneration 2023 12:21

    The original article was published in Translational Neurodegeneration 2021 10:50

  6. The inter-neuronal communication occurring in extensively branched neuronal cells is achieved primarily through the microtubule (MT)-mediated axonal transport system. This mechanistically regulated system deli...

    Authors: Padmashri Naren, Khan Sabiya Samim, Kamatham Pushpa Tryphena, Lalitkumar K. Vora, Saurabh Srivastava, Shashi Bala Singh and Dharmendra Kumar Khatri
    Citation: Translational Neurodegeneration 2023 12:20
  7. Redox homeostasis refers to the balance between the production of reactive oxygen species (ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is linked to all important ...

    Authors: Sina Shadfar, Sonam Parakh, Md Shafi Jamali and Julie D. Atkin
    Citation: Translational Neurodegeneration 2023 12:18
  8. The main clinical symptoms characteristic of Parkinson’s disease (PD) are bradykinesia, tremor, and other motor deficits. However, non-motor symptoms, such as visual disturbances, can be identified at early st...

    Authors: Xavier Sánchez-Sáez, Isabel Ortuño-Lizarán, Carla Sánchez-Castillo, Pedro Lax and Nicolás Cuenca
    Citation: Translational Neurodegeneration 2023 12:17

    The Correction to this article has been published in Translational Neurodegeneration 2023 12:22

  9. Neuropathological diagnosis of argyrophilic grain disease (AGD) is currently based primarily on the combination of argyrophilic grain (AG) visualized using Gallyas–Braak silver staining, phosphorylated tau-pos...

    Authors: Koji Yoshida, Yukiko Hata, Shojiro Ichimata, Keitaro Okada and Naoki Nishida
    Citation: Translational Neurodegeneration 2023 12:16
  10. In stressful or anxiety-provoking situations, most people with Parkinson’s disease (PD) experience a general worsening of motor symptoms, including their gait impairments. However, a proportion of patients act...

    Authors: Anouk Tosserams, Bastiaan R. Bloem, Kaylena A. Ehgoetz Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis and Jorik Nonnekes
    Citation: Translational Neurodegeneration 2023 12:15
  11. Authors: Hash Brown Taha, Simon Hornung, Suman Dutta, Leony Fenwick, Otmane Lahgui, Kathryn Howe, Nour Elabed, Irish del Rosario, Darice Y. Wong, Aline Duarte Folle, Daniela Markovic, Jose-Alberto Palma, Un Jung Kang, Roy N. Alcalay, Miriam Sklerov, Horacio Kaufmann…
    Citation: Translational Neurodegeneration 2023 12:14
  12. Nasal swabs are non-invasive testing methods for detecting diseases by collecting samples from the nasal cavity or nasopharynx. Dysosmia is regarded as an early sign of coronavirus disease 2019 (COVID-19), and...

    Authors: Suying Duan, Jing Yang, Zheqing Cui, Jiaqi Li, Honglin Zheng, Taiqi Zhao, Yanpeng Yuan, Yutao Liu, Lu Zhao, Yangyang Wang, Haiyang Luo and Yuming Xu
    Citation: Translational Neurodegeneration 2023 12:13
  13. α-Synucleinopathies, such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, are a class of neurodegenerative diseases exhibiting intracellular inclusions of misfolded α-...

    Authors: Matthias Schmitz, Niccolò Candelise, Sezgi Canaslan, Hermann C. Altmeppen, Jakob Matschke, Markus Glatzel, Neelam Younas, Saima Zafar, Peter Hermann and Inga Zerr
    Citation: Translational Neurodegeneration 2023 12:12
  14. Treatment for Alzheimer’s disease (AD) can be more effective in the early stages. Although we do not completely understand the aetiology of the early stages of AD, potential pathological factors (amyloid beta ...

    Authors: Sarawoot Somin, Don Kulasiri and Sandhya Samarasinghe
    Citation: Translational Neurodegeneration 2023 12:11
  15. Persistent inflammatory response in the brain can lead to tissue damage and neurodegeneration. In Alzheimer's disease (AD), there is an aberrant activation of inflammasomes, molecular platforms that drive infl...

    Authors: Cristina de Dios, Xenia Abadin, Vicente Roca-Agujetas, Marina Jimenez-Martinez, Albert Morales, Ramon Trullas, Montserrat Mari and Anna Colell
    Citation: Translational Neurodegeneration 2023 12:10
  16. Physical exercise is of great significance for maintaining human health. Exercise can provide varying degrees of benefits to cognitive function at all stages of life cycle. Currently, with the aging of the wor...

    Authors: Yi Lu, Fa-Qian Bu, Fang Wang, Li Liu, Shuai Zhang, Guan Wang and Xiu-Ying Hu
    Citation: Translational Neurodegeneration 2023 12:9
  17. Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions of...

    Authors: Yun Shen, Qian-kun Lv, Wei-ye Xie, Si-yi Gong, Sheng Zhuang, Jun-yi Liu, Cheng-jie Mao and Chun-feng Liu
    Citation: Translational Neurodegeneration 2023 12:8
  18. Neurodegenerative diseases are a set of progressive and currently incurable diseases that are primarily caused by neuron degeneration. Neurodegenerative diseases often lead to cognitive impairment and dyskines...

    Authors: Vaibhav Sharma, Fredrik Nikolajeff and Saroj Kumar
    Citation: Translational Neurodegeneration 2023 12:7
  19. Alzheimer’s disease (AD) is a progressive multifaceted neurodegenerative disorder for which no disease-modifying treatment exists. Neuroinflammation is central to the pathology progression, with evidence sugge...

    Authors: Luis Enrique Arroyo-García, Sara Bachiller, Rocío Ruiz, Antonio Boza-Serrano, Antonio Rodríguez-Moreno, Tomas Deierborg, Yuniesky Andrade-Talavera and André Fisahn
    Citation: Translational Neurodegeneration 2023 12:6
  20. The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with neurodegenerative diseases and the specific neurological manifestations of COVID-19 have aroused great interest. However, there are s...

    Authors: Pei Huang, Lin-Yuan Zhang, Yu-Yan Tan and Sheng-Di Chen
    Citation: Translational Neurodegeneration 2023 12:5

    The Correction to this article has been published in Translational Neurodegeneration 2023 12:23

  21. Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observ...

    Authors: Burak Yulug, Ozlem Altay, Xiangyu Li, Lutfu Hanoglu, Seyda Cankaya, Simon Lam, Halil Aziz Velioglu, Hong Yang, Ebru Coskun, Ezgi Idil, Rahim Nogaylar, Ahmet Ozsimsek, Cemil Bayram, Ismail Bolat, Sena Oner, Ozlem Ozdemir Tozlu…
    Citation: Translational Neurodegeneration 2023 12:4
  22. Increased neurofilament levels in biofluids are commonly used as a proxy for neurodegeneration in several neurodegenerative disorders. In this study, we aimed to investigate the distribution of neurofilaments ...

    Authors: Irene Frigerio, Max A. Laansma, Chen-Pei Lin, Emma J. M. Hermans, Maud M. A. Bouwman, John G. J. M. Bol, Yvon Galis-de Graaf, Dagmar H. Hepp, Annemieke J. M. Rozemuller, Frederik Barkhof, Wilma D. J. van de Berg and Laura E. Jonkman
    Citation: Translational Neurodegeneration 2023 12:3
  23. Authors: Ankit Verma, Anna Shteinfer-Kuzmine, Nikita Kamenetsky, Srinivas Pittala, Avijit Paul, Edna Nahon Crystal, Alberto Ouro, Vered Chalifa-Caspi, Swaroop Kumar Pandey, Alon Monsonego, Noga Vardi, Shira Knafo and Varda Shoshan-Barmatz
    Citation: Translational Neurodegeneration 2023 12:2

    The original article was published in Translational Neurodegeneration 2022 11:58

  24. Ribosomal protein S6 kinase 1 (S6K1) is a serine–threonine kinase that has two main isoforms: p70S6K (70-kDa isoform) and p85S6K (85-kDa isoform). p70S6K, with its upstream mammalian target of rapamycin (mTOR)...

    Authors: Jia-Bing Li, Xiao-Yu Hu, Mu-Wen Chen, Cai-Hong Xiong, Na Zhao, Yan-Hui Ge, Hao Wang, Xiao-Ling Gao, Nan-Jie Xu, Lan-Xue Zhao, Zhi-Hua Yu, Hong-Zhuan Chen and Yu Qiu
    Citation: Translational Neurodegeneration 2023 12:1
  25. Alzheimer's disease (AD) exhibits mitochondrial dysfunctions associated with dysregulated metabolism, brain inflammation, synaptic loss, and neuronal cell death. As a key protein serving as the mitochondrial g...

    Authors: Ankit Verma, Anna Shteinfer-Kuzmine, Nikita Kamenetsky, Srinivas Pittala, Avijit Paul, Edna Nahon Crystal, Alberto Ouro, Vered Chalifa-Caspi, Swaroop Kumar Pandey, Alon Monsonego, Noga Vardi, Shira Knafo and Varda Shoshan-Barmatz
    Citation: Translational Neurodegeneration 2022 11:58

    The Correction to this article has been published in Translational Neurodegeneration 2023 12:2

  26. Aducanumab (Adu), which is a human IgG1 monoclonal antibody that targets oligomer and fibril forms of beta-amyloid, has been reported to reduce amyloid pathology and improve impaired cognition after administra...

    Authors: Chanho Kong, Eun-Jeong Yang, Jaewoo Shin, Junwon Park, Si-Hyun Kim, Seong-Wook Park, Won Seok Chang, Chang-Han Lee, Hyunju Kim, Hye-Sun Kim and Jin Woo Chang
    Citation: Translational Neurodegeneration 2022 11:57
  27. Amyotrophic lateral sclerosis (ALS) is a disease characterized by upper and lower motor neuron (MN) loss with a signature feature of cytoplasmic aggregates containing TDP-43, which are detected in nearly all p...

    Authors: Sarah Lépine, Maria José Castellanos-Montiel and Thomas Martin Durcan
    Citation: Translational Neurodegeneration 2022 11:56
  28. Hijacking the transferrin receptor (TfR) is an effective strategy to transport amyloid-beta (Aβ) immuno-positron emission tomography (immunoPET) ligands across the blood–brain barrier (BBB). Such ligands are m...

    Authors: Gillian Bonvicini, Stina Syvänen, Ken G. Andersson, Merja Haaparanta-Solin, Francisco López-Picón and Dag Sehlin
    Citation: Translational Neurodegeneration 2022 11:55
  29. Amyotrophic lateral sclerosis (ALS) is an adult-onset paralytic disease characterized by progressive degeneration of upper and lower motor neurons in the motor cortex, brainstem and spinal cord. Motor neuron d...

    Authors: Winanto Ng and Shi-Yan Ng
    Citation: Translational Neurodegeneration 2022 11:54
  30. Axons, crucial for impulse transmission and cellular trafficking, are thought to be primary targets of neurodegeneration in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Axonal degeneration occ...

    Authors: Yasmine Y. Fathy, Laura E. Jonkman, John J. Bol, Evelien Timmermans, Allert J. Jonker, Annemieke J. M. Rozemuller and Wilma D. J. van de Berg
    Citation: Translational Neurodegeneration 2022 11:52
  31. Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has shown potential for the treatment of mild-to-moderate Alzheimer’s disease (AD). However, there is little evidence of whether NBM-DBS can...

    Authors: Yin Jiang, Tian-Shuo Yuan, Ying-Chuan Chen, Peng Guo, Teng-Hong Lian, Yu-Ye Liu, Wei Liu, Yu-Tong Bai, Quan Zhang, Wei Zhang and Jian-Guo Zhang
    Citation: Translational Neurodegeneration 2022 11:51
  32. Neurodegenerative disorders are one of the most common causes of disability and represent 6.3% of the global burden of disease. Among them, Alzheimer’s, Parkinson’s, and Huntington’s diseases cause cognitive d...

    Authors: Francesca Natale, Salvatore Fusco and Claudio Grassi
    Citation: Translational Neurodegeneration 2022 11:50
  33. Microbiome-gut-brain axis may be involved in the progression of age-related cognitive impairment and relevant brain structure changes, but evidence from large human cohorts is lacking. This study was aimed to ...

    Authors: Xinxiu Liang, Yuanqing Fu, Wen-ting Cao, Zhihong Wang, Ke Zhang, Zengliang Jiang, Xiaofang Jia, Chun-ying Liu, Hong-rou Lin, Haili Zhong, Zelei Miao, Wanglong Gou, Menglei Shuai, Yujing Huang, Shengdi Chen, Bing Zhang…
    Citation: Translational Neurodegeneration 2022 11:49
  34. This literature review investigates the significant overlap between myelin-repair signaling pathways and pathways known to contribute to hallmark pathologies of Alzheimer’s disease (AD). We discuss previously ...

    Authors: Lauren Rose Hirschfeld, Shannon L. Risacher, Kwangsik Nho and Andrew J. Saykin
    Citation: Translational Neurodegeneration 2022 11:47
  35. Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease that affects neurons in the central nervous system and the spinal cord. As in many other neurodegenerative disorders, ...

    Authors: Panlin Liao, Yanchun Yuan, Zhen Liu, Xiaorong Hou, Wanzhen Li, Jin Wen, Kexuan Zhang, Bin Jiao, Lu Shen, Hong Jiang, Jifeng Guo, Beisha Tang, Zhuohua Zhang, Zhonghua Hu and Junling Wang
    Citation: Translational Neurodegeneration 2022 11:46
  36. The ε4 allele of apolipoprotein E (APOE ε4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD), associated with amyloid pathogenesis. However, it is not clear how APOE ε4 accelerat...

    Authors: Hongwon Kim, Siyoung Kim, Byounggook Cho, Jaein Shin and Jongpil Kim
    Citation: Translational Neurodegeneration 2022 11:45
  37. Aberrant aggregation of α-synuclein (α-syn) is a key pathological feature of Parkinson’s disease (PD), but the precise role of intestinal α-syn in the progression of PD is unclear. In a number of genetic Drosophi...

    Authors: Wei Liu, Kah-Leong Lim and Eng-King Tan
    Citation: Translational Neurodegeneration 2022 11:44
  38. Continuous drug delivery (CDD) is used in moderately advanced and late-stage Parkinson’s disease (PD) to control motor and non-motor fluctuations (‘OFF’ periods). Transdermal rotigotine is indicated for early ...

    Authors: Silvia Rota, Daniele Urso, Daniel J. van Wamelen, Valentina Leta, Iro Boura, Per Odin, Alberto J. Espay, Peter Jenner and K. Ray Chaudhuri
    Citation: Translational Neurodegeneration 2022 11:43
  39. Alzheimer’s disease (AD) is a progressive neurodegenerative disease with phenotypic changes closely associated with both genetic variants and imaging pathology. Brain imaging biomarker genomics has been develo...

    Authors: Lanlan Li, Xianfeng Yu, Can Sheng, Xueyan Jiang, Qi Zhang, Ying Han and Jiehui Jiang
    Citation: Translational Neurodegeneration 2022 11:42
  40. Aberrant DNA methylation patterns have been observed in neurodegenerative diseases, including Alzheimer's disease (AD), and dynamic changes in DNA methylation are closely associated with the onset and progress...

    Authors: Hanseul Park, Jaein Shin, Yunkyung Kim, Takashi Saito, Takaomi C. Saido and Jongpil Kim
    Citation: Translational Neurodegeneration 2022 11:41
  41. Furin is an important mammalian proprotein convertase that catalyzes the proteolytic maturation of a variety of prohormones and proproteins in the secretory pathway. In the brain, the substrates of furin inclu...

    Authors: Yi Zhang, Xiaoqin Gao, Xue Bai, Shanshan Yao, Yan-Zhong Chang and Guofen Gao
    Citation: Translational Neurodegeneration 2022 11:39
  42. Authors: Matilde Bongianni, Mauro Catalan, Daniela Perra, Elena Fontana, Francesco Janes, Claudio Bertolotti, Luca Sacchetto, Stefano Capaldi, Matteo Tagliapietra, Paola Polverino, Valentina Tommasini, Giulia Bellavita, Elham Ataie Kachoie, Roberto Baruca, Andrea Bernardini, Mariarosaria Valente…
    Citation: Translational Neurodegeneration 2022 11:38

    The original article was published in Translational Neurodegeneration 2022 11:37

  43. In patients with Parkinson’s disease (PD), real-time quaking-induced conversion (RT-QuIC) detection of pathological α-synuclein (α-syn) in olfactory mucosa (OM) is not as accurate as in other α-synucleinopathi...

    Authors: Matilde Bongianni, Mauro Catalan, Daniela Perra, Elena Fontana, Francesco Janes, Claudio Bertolotti, Luca Sacchetto, Stefano Capaldi, Matteo Tagliapietra, Paola Polverino, Valentina Tommasini, Giulia Bellavita, Elham Ataie Kachoie, Roberto Baruca, Andrea Bernardini, Mariarosaria Valente…
    Citation: Translational Neurodegeneration 2022 11:37

    The Correction to this article has been published in Translational Neurodegeneration 2022 11:38

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