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Review
Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid β-protein (Aβ) in the leptomeningeal and cortical blood vessels, which is an age-dependent risk factor for intracerebral hemorrha...
Translational Neurodegeneration 2017 6:22
Published on: 17 August 2017
Review
Traumatic brain injury is among the most common causes of death and disability in youth and young adults. In addition to the acute risk of morbidity with moderate to severe injuries, traumatic brain injury is ...
Translational Neurodegeneration 2017 6:20
Published on: 11 July 2017
Review
Alzheimer’s disease (AD) is a chronic neurodegenerative disease, which is associated with learning and memory impairment in the elderly. Recent studies have found that treating AD in the way of chromatin remod...
Translational Neurodegeneration 2017 6:19
Published on: 10 July 2017
Review
Evidence from epidemiological studies suggest a relationship between cigarette smoking and low risk of Parkinson disease (PD). As a major component of tobacco smoke, nicotine has been proposed to be a substanc...
Translational Neurodegeneration 2017 6:18
Published on: 2 July 2017
Research
There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease (PD-MCI) and the coping strategies used by these caregivers.
Translational Neurodegeneration 2017 6:17
Published on: 19 June 2017
Review
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by a rapid loss of lower and upper motor neurons. As a complex disease, the ageing process and complicated gene-environmen...
Translational Neurodegeneration 2017 6:15
Published on: 16 June 2017
Review
Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. Since distinct diseases can cause similar tremor manifestations and vice-versa, it is...
Translational Neurodegeneration 2017 6:16
Published on: 16 June 2017
Research
Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for Parkinson’s disease (PD), the predictive effect of levodopa responsiveness on surgical outcomes was confirmed by some studies,...
Translational Neurodegeneration 2017 6:14
Published on: 26 May 2017
Research
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a new candidate growth factor for dopaminergic neurons against endoplasmic reticulum stress (ER stress). HSP70 family, a chaperon like heat shock p...
Translational Neurodegeneration 2017 6:12
Published on: 22 May 2017
Review
Some studies have shown that low frequency stimulation (LFS, most commonly 60 Hz), compared to high frequency stimulation (HFS, most commonly 130 Hz), has beneficial effects, short-term or even long-term, on i...
Translational Neurodegeneration 2017 6:13
Published on: 17 May 2017
Research
Recent studies have found that the functional catechol-O-methyltransferase (COMT) gene may be associated with the susceptibility to and pharmacotherapy of Parkinson’s disease (PD). In this case–control study, ...
Translational Neurodegeneration 2017 6:11
Published on: 26 April 2017
Research
Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis, which converts glutamine into glutamate. Glutamate is the major neurotransmitter of excitatory synapses,...
Translational Neurodegeneration 2017 6:10
Published on: 20 April 2017
Research
The hereditary spastic paraplegias (HSPs) are a group of clinically and genetically heterogeneous disorders. Approximately 10% of the autosomal dominant (AD) HSPs (ADHSPs) have the spastic paraplegia 3A (SPG3A...
Translational Neurodegeneration 2017 6:9
Published on: 4 April 2017
Review
Two centuries ago in 1817, James Parkinson provided the first medical description of Parkinson’s disease, later refined by Jean-Martin Charcot in the mid-to-late 19th century to include the atypical parkinsoni...
Translational Neurodegeneration 2017 6:8
Published on: 28 March 2017
Review
Cognitive decline poses a great concern to elderly people and their families. In addition to pharmacological therapies, several varieties of nonpharmacological intervention have been developed. Most training t...
Translational Neurodegeneration 2017 6:7
Published on: 28 March 2017
Review
A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse. Therapeutic options are currently...
Translational Neurodegeneration 2017 6:6
Published on: 13 March 2017
Research
It is increasingly clear that in addition to myelin disruption, axonal degeneration may also represent a key pathology in multiple sclerosis (MS). Hence, elucidating the mechanisms of axonal degeneration may n...
Translational Neurodegeneration 2017 6:5
Published on: 28 February 2017
Review
Neurodegeneration of Parkinson’s disease (PD) starts in an insidious manner, 30–50% of dopaminergic neurons have been lost in the substantia nigra before clinical diagnosis. Prodromal stage of the disease, dur...
Translational Neurodegeneration 2017 6:4
Published on: 20 February 2017
Review
Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular componen...
Translational Neurodegeneration 2017 6:3
Published on: 2 February 2017
Review
Alzheimer’s Disease (AD) is a global health issue given the increasing prevalence rate and the limitations of drug effects. As a consequent, non-pharmacological interventions are of importance. Music therapy (...
Translational Neurodegeneration 2017 6:2
Published on: 25 January 2017
Review
L-3, 4-Dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) is a major clinical complication in the treatment of Parkinson’s disease (PD). This debilitating side effect likely reflects aberrant compensator...
Translational Neurodegeneration 2017 6:1
Published on: 17 January 2017
Case report
Acute-onset neurodegenerative diseases in older patients are rare clinical cases, especially when the degeneration only affects specific regions of the nervous system. Several neurological disorders have been ...
Translational Neurodegeneration 2016 5:23
Published on: 27 December 2016
Research
Diabetes is the most common metabolic disease with many chronic complications, and cognitive disorders are one of the common complications in patients with diabetes. Previous studies have showed that autophagy...
Translational Neurodegeneration 2016 5:22
Published on: 12 December 2016
Research
Alzheimer’s disease (AD) is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe treatment ag...
Translational Neurodegeneration 2016 5:21
Published on: 29 November 2016
Review
Amyloid plaques are pathological hallmarks of Alzheimer’s Disease (AD) and biomarkers such as cerebrospinal fluid (CSF) β-amyloid 1–42 (Aβ1-42) and amyloid positron emission tomographic (PET) imaging are impor...
Translational Neurodegeneration 2016 5:20
Published on: 16 November 2016
