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  1. Content type: Review

    Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During the course of disease, misfolded α-syn...

    Authors: Shirley Yin-Yu Pang, Philip Wing-Lok Ho, Hui-Fang Liu, Chi-Ting Leung, Lingfei Li, Eunice Eun Seo Chang, David Boyer Ramsden and Shu-Leong Ho

    Citation: Translational Neurodegeneration 2019 8:23

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  2. Content type: Research

    Parkinson’s disease (PD) is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative parkinsonisms. PD is characterized by intraneuronal accumulatio...

    Authors: Chiara Maria Giulia De Luca, Antonio Emanuele Elia, Sara Maria Portaleone, Federico Angelo Cazzaniga, Martina Rossi, Edoardo Bistaffa, Elena De Cecco, Joanna Narkiewicz, Giulia Salzano, Olga Carletta, Luigi Romito, Grazia Devigili, Paola Soliveri, Pietro Tiraboschi, Giuseppe Legname, Fabrizio Tagliavini…

    Citation: Translational Neurodegeneration 2019 8:24

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  3. Content type: Review

    The number and health burden of Parkinson’s disease increase rapidly in China. It is estimated that China will have nearly half of the Parkinson’s disease population in the world in 2030. In this review, we pr...

    Authors: Gen Li, Jianfang Ma, Shishuang Cui, Yixi He, Qin Xiao, Jun Liu and Shengdi Chen

    Citation: Translational Neurodegeneration 2019 8:22

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  4. Content type: Research

    Although many causative genes of hereditary spastic paraplegia (HSP) have been uncovered in recent years, there are still approximately 50% of HSP patients without genetically diagnosis, especially in autosoma...

    Authors: Qiao Wei, Hai-Lin Dong, Li-Ying Pan, Cong-Xin Chen, Yang-Tian Yan, Rou-Min Wang, Hong-Fu Li, Zhi-Jun Liu, Qing-Qing Tao and Zhi-Ying Wu

    Citation: Translational Neurodegeneration 2019 8:19

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  5. Content type: Research

    Progressive accumulation of α-synuclein is a key step in the pathological development of Parkinson’s disease. Impaired protein degradation and increased levels of α-synuclein may trigger a pathological aggrega...

    Authors: Jia-Zhen Wu, Mustafa Ardah, Caroline Haikal, Alexander Svanbergsson, Meike Diepenbroek, Nishant N. Vaikath, Wen Li, Zhan-You Wang, Tiago F. Outeiro, Omar M. El-Agnaf and Jia-Yi Li

    Citation: Translational Neurodegeneration 2019 8:18

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  6. Content type: Research

    Parkinson’s disease (PD), the most common neurodegenerative movement disorder, is characterized by dopaminergic nigrostriatal neuron loss and brain accumulation of Lewy bodies, protein aggregates mainly compos...

    Authors: Edoardo Parrella, Arianna Bellucci, Vanessa Porrini, Marina Benarese, Annamaria Lanzillotta, Gaia Faustini, Francesca Longhena, Giulia Abate, Daniela Uberti and Marina Pizzi

    Citation: Translational Neurodegeneration 2019 8:16

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  7. Content type: Research

    Erythrocytes are a major source of peripheral α-synuclein (α-Syn). The goal of the current investigation is to evaluate erythrocytic total, oligomeric/aggregated, and phosphorylated α-Syn species as biomarkers...

    Authors: Chen Tian, Genliang Liu, Liyan Gao, David Soltys, Catherine Pan, Tessandra Stewart, Min Shi, Zhiying Xie, Na Liu, Tao Feng and Jing Zhang

    Citation: Translational Neurodegeneration 2019 8:15

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  8. Content type: Research

    Few studies have investigated the effects of blood glucose (BG) on cognitive function in community-dwelling elderly individuals carrying the apolipoprotein E (APOE) ε3 allele.

    Authors: Qi Qiu, Xiang Lin, Lin Sun, Min-jie Zhu, Tao Wang, Jing-hua Wang, Guan-jun Li, Shi-fu Xiao and Xia Li

    Citation: Translational Neurodegeneration 2019 8:12

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  9. Content type: Research

    IgG-class autoantibodies to N-Methyl-D-Aspartate (NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis. Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with P...

    Authors: Franziska Hopfner, Stefanie H. Müller, Dagmar Steppat, Joanna Miller, Nele Schmidt, Klaus-Peter Wandinger, Frank Leypoldt, Daniela Berg, Andre Franke, Wolfgang Lieb, Lukas Tittmann, Monika Balzer-Geldsetzer, Simon Baudrexel, Richard Dodel, Ruediger Hilker-Roggendorf, Elke Kalbe…

    Citation: Translational Neurodegeneration 2019 8:11

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  10. Content type: Research

    Amyotrophic lateral sclerosis (ALS) is a late onset neurodegenerative disease with fast progression. ALS has heavy genetic components in which a series of genetic mutations have been identified. In 2013, Mutat...

    Authors: Cheng Cheng, Kan Yang, Xinwei Wu, Yuefang Zhang, Shifang Shan, Aaron Gitler, Anirvan Ghosh and Zilong Qiu

    Citation: Translational Neurodegeneration 2019 8:13

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  11. Content type: Research

    The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous ...

    Authors: José Aguareles, Juan Paraíso-Luna, Belén Palomares, Raquel Bajo-Grañeras, Carmen Navarrete, Andrea Ruiz-Calvo, Daniel García-Rincón, Elena García-Taboada, Manuel Guzmán, Eduardo Muñoz and Ismael Galve-Roperh

    Citation: Translational Neurodegeneration 2019 8:9

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  12. Content type: Research

    Building brain reserves before dementia onset could represent a promising strategy to prevent Alzheimer’s disease (AD), while how to initiate early cognitive stimulation is unclear. Given that the immature bra...

    Authors: Enjie Liu, Qiuzhi Zhou, Ao-Ji Xie, Mengzhu Li, Shujuan Zhang, Hezhou Huang, Zhenyu Liuyang, Yali Wang, Bingjin Liu, Xiaoguang Li, Dongsheng Sun, Yuping Wei, Xiaochuan Wang, Qun Wang, Dan Ke, Xifei Yang…

    Citation: Translational Neurodegeneration 2019 8:8

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  13. Content type: Research

    Abnormal aggregation of brain α-synuclein is a central step in the pathogenesis of Parkinson’s disease (PD), thus, it is reliable to promote the clearance of α-synuclein to prevent and treat PD. Recent studies...

    Authors: Wenyan Zou, Tinglin Pu, Weixi Feng, Ming Lu, Ying Zheng, Renhong Du, Ming Xiao and Gang Hu

    Citation: Translational Neurodegeneration 2019 8:7

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  14. Content type: Research

    Gastrointestinal dysfunction can affect Parkinson’s disease (PD) patients long before the onset of motor symptoms. However, little is known about the relationship between gastrointestinal abnormalities and the...

    Authors: Lucia Rota, Carolina Pellegrini, Laura Benvenuti, Luca Antonioli, Matteo Fornai, Corrado Blandizzi, Antonino Cattaneo and Emanuela Colla

    Citation: Translational Neurodegeneration 2019 8:5

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  15. Content type: Review

    Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, which is characterized by the progressive loss of dopaminergic neurons in the Substantia Nigra pars compacta concomitant with Le...

    Authors: Zhi Dong Zhou, Thevapriya Selvaratnam, Ji Chao Tristan Lee, Yin Xia Chao and Eng-King Tan

    Citation: Translational Neurodegeneration 2019 8:6

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  16. Content type: Research

    Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease (AD) have not been fully clarified. 5-Hydroxytryptamine transporter gene-linked polymorphic region (5-HTTLPR) is a variable number ta...

    Authors: Grazia D’Onofrio, Francesco Panza, Daniele Sancarlo, Michele Lauriola, Mariangela P. Dagostino, Giulia Paroni, Madia Lozupone, Antonio Mangiacotti, Paola Bisceglia, Carolina Gravina, Maria Urbano, Filomena Addante, Francesco Paris, Leandro Cascavilla, Antonio Greco and Davide Seripa

    Citation: Translational Neurodegeneration 2019 8:4

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  17. Content type: Research

    Parkinson’s disease (PD) is characterized by a chronic loss of dopaminergic neurons and the presence of proteinaceous inclusions (Lewy bodies) within some remaining neurons in the substantia nigra. Recently, a...

    Authors: Shen-zhao Lu, Yong-shun Guo, Pei-zhou Liang, Shu-zhen Zhang, Shu Yin, Yan-qing Yin, Xiao-min Wang, Fei Ding, Xiao-song Gu and Jia-wei Zhou

    Citation: Translational Neurodegeneration 2019 8:3

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  18. Content type: Research

    SOD1 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) in non-Caucasian patients. Detailed natural history profiles of SOD1-mutant patients will be beneficial for the strategy and interpr...

    Authors: Lu Tang, Yan Ma, Xiao-lu Liu, Lu Chen and Dong-sheng Fan

    Citation: Translational Neurodegeneration 2019 8:2

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    The Correction to this article has been published in Translational Neurodegeneration 2019 8:10

  19. Content type: Research

    Parkinson’s Disease (PD) with mild cognitive impairment (MCI) (PD-MCI) represents one of the most dreaded complications for patients with PD and is associated with a higher risk of developing dementia. Althoug...

    Authors: Mauro Adenzato, Rosa Manenti, Ivan Enrici, Elena Gobbi, Michela Brambilla, Antonella Alberici, Maria Sofia Cotelli, Alessandro Padovani, Barbara Borroni and Maria Cotelli

    Citation: Translational Neurodegeneration 2019 8:1

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  20. Content type: Review

    Alzheimer’s disease (AD) is a fatal disease that threatens the quality of life of an aging population at a global scale. Various hypotheses on the etiology of AD have been developed over the years to guide eff...

    Authors: Hongmei Li, Chia-Chen Liu, Hui Zheng and Timothy Y. Huang

    Citation: Translational Neurodegeneration 2018 7:34

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  21. Content type: Correction

    In the original publication of this article [1] surname of the first author is wrong.

    Authors: Dan Zheng, Wei Xia, Zhong Quan Yi, Pan Wen Zhao, Jian Guo Zhong, Hai Cun Shi, Hua Liang Li, Zhen Yu Dai and Ping Lei Pan

    Citation: Translational Neurodegeneration 2018 7:33

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    The original article was published in Translational Neurodegeneration 2018 7:26

  22. Content type: Research

    Neuron-microglia communication plays a crucial role in the motor neurons (MNs) death in amyotrophic lateral sclerosis (ALS). Neurons can express chemokine (C-X3-C motif) ligand 1 (CX3CL1), which mediates micro...

    Authors: Jingjing Zhang, Yufei Liu, Xinyao Liu, Song Li, Cheng Cheng, Sheng Chen and Weidong Le

    Citation: Translational Neurodegeneration 2018 7:35

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  23. Content type: Research

    Rasagiline is a monoamine oxidase-B inhibitor used for Parkinson’s disease (PD) treatment, but its effectiveness on Chinese patients is unclear. This study aimed to evaluate the efficacy and safety of rasagili...

    Authors: Zhenxin Zhang, Jian Wang, Shengdi Chen, Chunfeng Liu, Baorong Zhang, Rong Peng, Shenggang Sun, Xiangru Sun, Gang Zhao, Qiumin Qu, Yansheng Li, Suiqiang Zhu, Xiaoping Pan, Ming Shao and Yanping Wang

    Citation: Translational Neurodegeneration 2018 7:32

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  24. Content type: Short report

    The TANK-Binding Kinase 1 (TBK1) gene has recently been identified as the third or fourth most frequent cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The aim of this study was to...

    Authors: Bin Jiao, Qiying Sun, Zhenhua Yuan, Junling Wang, Lin Zhou, Xinxiang Yan, Beisha Tang and Lu Shen

    Citation: Translational Neurodegeneration 2018 7:31

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  25. Content type: Research

    Amyotrophic lateral sclerosis (ALS) is currently an incurable disease without highly effective pharmacological treatments. The peptide drug GM604 (GM6 or Alirinetide) was developed as a candidate ALS therapy, ...

    Authors: William R. Swindell, Krzysztof Bojanowski, Mark S. Kindy, Raymond M. W. Chau and Dorothy Ko

    Citation: Translational Neurodegeneration 2018 7:30

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  26. Content type: Research

    Resting-state functional magnetic resonance imaging studies using a regional homogeneity (ReHo) method have reported that amnestic mild cognitive impairment (aMCI) was associated with abnormalities in local fu...

    Authors: Dan Zheng, Wei Xia, Zhong Quan Yi, Pan Wen Zhao, Jian Guo Zhong, Hai Cun Shi, Hua Liang Li, Zhen Yu Dai and Ping Lei Pan

    Citation: Translational Neurodegeneration 2018 7:26

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    The Correction to this article has been published in Translational Neurodegeneration 2018 7:33

  27. Content type: Research

    Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demo...

    Authors: Antonella Tramutola, Chiara Lanzillotta, Eugenio Barone, Andrea Arena, Ilaria Zuliani, Luciana Mosca, Carla Blarzino, D. Allan Butterfield, Marzia Perluigi and Fabio Di Domenico

    Citation: Translational Neurodegeneration 2018 7:28

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  28. Content type: Research

    Cell replacement therapy has been envisioned as a promising treatment for neurodegenerative diseases. Due to the ethical concerns of ESCs-derived neural progenitor cells (NPCs) and tumorigenic potential of iPS...

    Authors: Kangmu Ma, Xiaobei Deng, Xiaohuan Xia, Zhaohuan Fan, Xinrui Qi, Yongxiang Wang, Yuju Li, Yizhao Ma, Qiang Chen, Hui Peng, Jianqing Ding, Chunhong Li, Yunlong Huang, Changhai Tian and Jialin C. Zheng

    Citation: Translational Neurodegeneration 2018 7:29

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  29. Content type: Research

    Individuals with subjective memory complaints (SMC) feature a higher risk of cognitive decline and clinical progression of Alzheimer’s disease (AD). However, the pathological mechanism underlying SMC remains u...

    Authors: Kaicheng Li, Xiao Luo, Qingze Zeng, Yeerfan Jiaerken, Xiaojun Xu, Peiyu Huang, Zhujing Shen, Jingjing Xu, Chao Wang, Jiong Zhou and Min-Ming Zhang

    Citation: Translational Neurodegeneration 2018 7:27

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  30. Content type: Research

    Circadian rhythms are oscillating physiological and behavioral changes governed by an internal molecular clock, and dysfunctions in circadian rhythms have been associated with ageing and various neurodegenerat...

    Authors: Xin Jiang, Tao Zhang, Haifang Wang, Tao Wang, Meiling Qin, Puhua Bao, Ruiqi Wang, Yuwei Liu, Hung-Chun Chang, Jun Yan and Jin Xu

    Citation: Translational Neurodegeneration 2018 7:24

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  31. Content type: Research

    Rapid eye movement sleep behavior disorder (RBD) is associated with cognitive decline in early Parkinson’s disease (PD). However, the underlyling basis for this association remains unclear.

    Authors: Maowen Ba, Guoping Yu, Min Kong, Hui Liang and Ling Yu

    Citation: Translational Neurodegeneration 2018 7:22

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  32. Content type: Research

    Parkinson’s disease (PD) is a neurodegenerative disease characterized by intraneuronal Lewy Body (LB) aggregates composed of misfolded alpha-synuclein (α-syn). The spread of misfolded α-syn follows a typical p...

    Authors: Haichen Niu, Lingyu Shen, Tongzhou Li, Chao Ren, Sheng Ding, Lei Wang, Zhonghai Zhang, Xiaoyu Liu, Qiang Zhang, Deqin Geng, Xiujuan Wu and Haiying Li

    Citation: Translational Neurodegeneration 2018 7:25

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  33. Content type: Research

    Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative brain disorder, which is the most common form of dementia. Intensive efforts have been made to find effective and safe treatment aga...

    Authors: Yuhuan Shi, Wanying Huang, Yu Wang, Rui Zhang, Lina Hou, Jianrong Xu, Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Yongfang Zhang and Hao Wang

    Citation: Translational Neurodegeneration 2018 7:21

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  34. Content type: Research

    Visinin-like protein-1 (VILIP-1) and chitinase-3-like protein 1 (CHI3L1 or YKL-40) in cerebrospinal fluid (CSF) are newly discovered markers indicating neuronal damage and microglial activation, respectively. ...

    Authors: Hua Zhang, Kok Pin Ng, Joseph Therriault, Min Su Kang, Tharick A. Pascoal, Pedro Rosa-Neto and Serge Gauthier

    Citation: Translational Neurodegeneration 2018 7:23

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  35. Content type: Research

    Abnormal expression of major histocompatibility complex class I (MHC-I) is increased in dopaminergic (DA) neurons in the substantia nigra (SN) in Parkinson’s disease (PD). Low-molecular-mass protein 7 (β5i) is...

    Authors: Ming-Shu Mo, Gui-Hua Li, Cong-Cong Sun, Shu-Xuan Huang, Lei Wei, Li-Min Zhang, Miao-Miao Zhou, Zhuo-Hua Wu, Wen-Yuan Guo, Xin-Ling Yang, Chao-Jun Chen, Shao-Gang Qu, Jian-Xing He and Ping-Yi Xu

    Citation: Translational Neurodegeneration 2018 7:19

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  36. Content type: Research

    There is an urgent need for developing objective, effective and convenient measurements to help clinicians accurately identify bradykinesia. The purpose of this study is to evaluate the accuracy of an objectiv...

    Authors: Chao Gao, Stephen Smith, Michael Lones, Stuart Jamieson, Jane Alty, Jeremy Cosgrove, Pingchen Zhang, Jin Liu, Yimeng Chen, Juanjuan Du, Shishuang Cui, Haiyan Zhou and Shengdi Chen

    Citation: Translational Neurodegeneration 2018 7:18

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  37. Content type: Research

    Amyotrophic lateral sclerosis (ALS) is a disease characterized by a progressive degeneration of motor neurons leading to paralysis. Our previous MRI diffusion tensor imaging studies detected early white matter...

    Authors: Rodolfo G. Gatto, Manish Y. Amin, Daniel Deyoung, Matthew Hey, Thomas H. Mareci and Richard L. Magin

    Citation: Translational Neurodegeneration 2018 7:20

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  38. Content type: Research

    The cardinal features of Parkinson’s disease (PD) are bradykinesia, rigidity and rest tremor. Abnormal activity in the basal ganglia is predicted to underlie the mechanism of motor symptoms. This study aims to...

    Authors: G. Du, P. Zhuang, M. Hallett, Y.-Q. Zhang, J.-Y. Li and Y.-J. Li

    Citation: Translational Neurodegeneration 2018 7:17

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  39. Content type: Research

    The differential diagnosis of Parkinson’s disease (PD) and multiple system atrophy (MSA) remains a challenge, especially in the early stage. Here, we assessed the value of transcranial sonography (TCS) to disc...

    Authors: Hai-Yan Zhou, Pei Huang, Qian Sun, Juan-Juan Du, Shi-Shuang Cui, Yun-Yun Hu, Wei-Wei Zhan, Ying Wang, Qin Xiao, Jun Liu, Yu-Yan Tan and Sheng-Di Chen

    Citation: Translational Neurodegeneration 2018 7:15

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  40. Content type: Research

    Cognitive impairment is one of the non-motor symptoms in Parkinson’s disease (PD). In the present study, we aim to examine the cognitive function of non-demented Parkinson’s disease patients and compare the re...

    Authors: Ke Yang, Bo Shen, Da-ke Li, Ying Wang, Jue Zhao, Jian Zhao, Wen-Bo Yu, Zhen-yang Liu, Yi-lin Tang, Feng-tao Liu, Huan Yu, Jian Wang, Qi-hao Guo and Jian-jun Wu

    Citation: Translational Neurodegeneration 2018 7:16

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  41. Content type: Research

    The use of adjunct rasagiline in levodopa-treated patients with Parkinson’s disease and motor fluctuations is supported by findings from large-scale clinical studies. This study is to investigate the efficacy ...

    Authors: Zhenxin Zhang, Ming Shao, Shengdi Chen, Chunfeng Liu, Rong Peng, Yansheng Li, Jian Wang, Suiqiang Zhu, Qiumin Qu, Xiaoying Zhang, Haibo Chen, Xiangru Sun, Yanping Wang, Shenggang Sun, Baorong Zhang, Jimei Li…

    Citation: Translational Neurodegeneration 2018 7:14

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  42. Content type: Short report

    Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, neuropathologically characterized by misfolded protein aggregation, called Lewy bodies and Lewy neurites. PD is a slow-progressive...

    Authors: Qian-Qian Chen, Caroline Haikal, Wen Li, Ming-Tao Li, Zhan-You Wang and Jia-Yi Li

    Citation: Translational Neurodegeneration 2018 7:13

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  43. Content type: Review

    The NIA-AA research framework proposes a biological definition of Alzheimer’s disease, where asymptomatic persons with amyloid deposition would be considered as having this disease prior to symptoms.

    Authors: S. Gauthier, H. Zhang, K. P. Ng, T.A. Pascoal and P. Rosa-Neto

    Citation: Translational Neurodegeneration 2018 7:12

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  44. Content type: Review

    Deep Brain Stimulation (DBS) therapy for the treatment of Parkinson’s Disease (PD) is now a well-established option for some patients. Postoperative standardized programming processes can improve the level of ...

    Authors: Shengdi Chen, Guodong Gao, Tao Feng and Jianguo Zhang

    Citation: Translational Neurodegeneration 2018 7:11

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  45. Content type: Research

    Brain consists of plenty of complicated cytoarchitecture. Gaussian-model based diffusion tensor imaging (DTI) is far from satisfactory interpretation of the structural complexity. Diffusion kurtosis imaging (D...

    Authors: Jia-Xing Cheng, Hong-Ying Zhang, Zheng-Kun Peng, Yao Xu, Hui Tang, Jing-Tao Wu and Jun Xu

    Citation: Translational Neurodegeneration 2018 7:10

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