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  1. Blood-based test for predicting disease progression and early diagnosis of Parkinson’s disease (PD) is an unmet need in the clinic. The profiles of microRNAs (miRNAs) are regarded as potential diagnostic bioma...

    Authors: Shulei He, Lu Huang, Ci Shao, Tiejian Nie, Li Xia, Bozhou Cui, Fangfang Lu, Lin Zhu, Bolin Chen and Qian Yang

    Citation: Translational Neurodegeneration 2021 10:25

    Content type: Research

    Published on:

  2. Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by a gradual, insidious and progressive loss of language abilities, with naming difficulties being an early and persistent impair...

    Authors: Ilaria Pagnoni, Elena Gobbi, Enrico Premi, Barbara Borroni, Giuliano Binetti, Maria Cotelli and Rosa Manenti

    Citation: Translational Neurodegeneration 2021 10:24

    Content type: Review

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  3. Gait problems are an important symptom in Parkinson’s disease (PD), a progressive neurodegenerative disease. Transcranial direct current stimulation (tDCS) is a neuromodulatory intervention that can modulate c...

    Authors: Fateme Pol, Mohammad Ali Salehinejad, Hamzeh Baharlouei and Michael A. Nitsche

    Citation: Translational Neurodegeneration 2021 10:22

    Content type: Review

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  4. Accumulation of alpha-synuclein (α-syn) is a main pathological hallmark of Parkinson’s and related diseases, which are collectively known as synucleinopathies. Growing evidence has supported that the same prot...

    Authors: Di Liu, Jian-Jun Guo, Ji-Hui Su, Alexander Svanbergsson, Lin Yuan, Caroline Haikal, Wen Li, Gunnar Gouras and Jia-Yi Li

    Citation: Translational Neurodegeneration 2021 10:20

    Content type: Research

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  5. Mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s disease (PD), and several genes linked to familial PD, including PINK1 (encoding PTEN-induced putative kinase 1 [PINK1]) and PAR...

    Authors: Kai Yu Ma, Michiel R. Fokkens, Fulvio Reggiori, Muriel Mari and Dineke S. Verbeek

    Citation: Translational Neurodegeneration 2021 10:19

    Content type: Research

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  6. The aggregation of amyloid β (Aβ) is central in the pathogenesis of Alzheimer’s disease (AD). Recently it has been shown that specifically, larger, Thioflavin T-binding Aβ aggregates are associated with increa...

    Authors: Mari Aksnes, Hans Christian D. Aass, Ann Tiiman, Trine Holt Edwin, Lars Terenius, Nenad Bogdanović, Vladana Vukojević and Anne-Brita Knapskog

    Citation: Translational Neurodegeneration 2021 10:18

    Content type: Research

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  7. Increased catabolism has recently been recognized as a clinical manifestation of amyotrophic lateral sclerosis (ALS). The hypothalamic systems have been shown to be involved in the metabolic dysfunction in ALS...

    Authors: David Bayer, Stefano Antonucci, Hans-Peter Müller, Rami Saad, Luc Dupuis, Volker Rasche, Tobias M. Böckers, Albert C. Ludolph, Jan Kassubek and Francesco Roselli

    Citation: Translational Neurodegeneration 2021 10:17

    Content type: Research

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  8. Precursor messenger RNA (pre-mRNA) splicing is a fundamental step in eukaryotic gene expression that systematically removes non-coding regions (introns) and ligates coding regions (exons) into a continuous mes...

    Authors: Dunhui Li, Craig Stewart McIntosh, Frank Louis Mastaglia, Steve Donald Wilton and May Thandar Aung-Htut

    Citation: Translational Neurodegeneration 2021 10:16

    Content type: Review

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  9. Animal models provide an opportunity to assess the optimal treatment way and the underlying mechanisms of direct clinical application of adipose-derived stem cells (ADSCs). Previous studies have evaluated the ...

    Authors: Keya Li, Xinyue Li, Guiying Shi, Xuepei Lei, Yiying Huang, Lin Bai and Chuan Qin

    Citation: Translational Neurodegeneration 2021 10:14

    Content type: Review

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  10. The mechanisms underlying lesions of dopaminergic (DA) neurons, an essential pathology of Parkinson’s disease (PD), are largely unknown, although oxidative stress is recognized as a key factor. We have previou...

    Authors: Liangqin Shi, Yazhou Lin, Yucheng Jiao, Seth A. Herr, Jonathan Tang, Edmond Rogers, Zhengli Chen and Riyi Shi

    Citation: Translational Neurodegeneration 2021 10:13

    Content type: Research

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  11. Currently, there is no cure for Alzheimer’s disease (AD). Therapeutics that can modify the early stage of AD are urgently needed. Recent studies have shown that the pathogenesis of AD is closely regulated by a...

    Authors: Ju Wang, Hui-Jie Hu, Zi-Kai Liu, Jing-Jing Liu, Shan-Shan Wang, Qing Cheng, Hong-Zhuan Chen and Mingke Song

    Citation: Translational Neurodegeneration 2021 10:12

    Content type: Research

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  12. The development of in vivo biomarkers of Alzheimer’s disease (AD) has advanced the diagnosis of AD from a clinical syndrome to a biological construct. The preclinical stage of AD continuum is defined by the id...

    Authors: Kok Pin Ng, Hui Chiew, Pedro Rosa-Neto, Nagaendran Kandiah, Zahinoor Ismail and Serge Gauthier

    Citation: Translational Neurodegeneration 2021 10:11

    Content type: Review

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  13. A lack of convenient and reliable biomarkers for diagnosis and prognosis is a common challenge for neurodegenerative diseases such as Alzheimer’s disease (AD). Recent advancement in ultrasensitive protein assa...

    Authors: Xulong Ding, Shuting Zhang, Lijun Jiang, Lu Wang, Tao Li and Peng Lei

    Citation: Translational Neurodegeneration 2021 10:10

    Content type: Review

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  14. α-Synuclein has been studied as a potential biomarker for Parkinson’s disease (PD) with no concluding results. Accordingly, there is an urgent need to find out reliable specific biomarkers for PD. GPR37 is an ...

    Authors: Xavier Morató, Paula Garcia-Esparcia, Josep Argerich, Franc Llorens, Inga Zerr, Wojciech Paslawski, Eva Borràs, Eduard Sabidó, Ulla E. Petäjä-Repo, Víctor Fernández-Dueñas, Isidro Ferrer, Per Svenningsson and Francisco Ciruela

    Citation: Translational Neurodegeneration 2021 10:8

    Content type: Research

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  15. Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes. Paroxysmal kinesigenic dyskinesia (PKD) is the most common typ...

    Authors: Li Cao, Xiaojun Huang, Ning Wang, Zhiying Wu, Cheng Zhang, Weihong Gu, Shuyan Cong, Jianhua Ma, Ling Wei, Yanchun Deng, Qi Fang, Qi Niu, Jin Wang, Zhaoxia Wang, You Yin, Jinyong Tian…

    Citation: Translational Neurodegeneration 2021 10:7

    Content type: Review

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  16. As the most common form of dementia, Alzheimer’s disease (AD) is characterized by progressive cognitive impairments and constitutes a major social burden. Currently, the invasiveness and high costs of tests ha...

    Authors: Ying Zhang, Yanjiang Wang, Ce Shi, Meixiao Shen and Fan Lu

    Citation: Translational Neurodegeneration 2021 10:6

    Content type: Review

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  17. The familial form of Parkinson’s disease (PD) is linked to mutations in specific genes. The mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active...

    Authors: Iryna Kamienieva, Jerzy Duszyński and Joanna Szczepanowska

    Citation: Translational Neurodegeneration 2021 10:5

    Content type: Review

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  18. Current therapies for Parkinson’s disease (PD) are palliative, of which the levodopa/carbidopa therapy remains the primary choice but is unable to modulate the progression of neurodegeneration. Due to the comp...

    Authors: Tapan Behl, Gagandeep Kaur, Ovidiu Fratila, Camelia Buhas, Claudia Teodora Judea-Pusta, Nicoleta Negrut, Cristiana Bustea and Simona Bungau

    Citation: Translational Neurodegeneration 2021 10:4

    Content type: Review

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  19. Accumulating evidence has suggested that the pathological changes in amyotrophic lateral sclerosis (ALS) are not only confined to the central nervous system but also occur in the peripheral circulating system....

    Authors: Yangfan Cheng, Yongping Chen and Huifang Shang

    Citation: Translational Neurodegeneration 2021 10:3

    Content type: Review

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  20. Neuropsychiatric symptoms (NPS) are increasingly recognized as early non-cognitive manifestations in the Alzheimer’s disease (AD) continuum. However, the role of NPS as an early marker of pathophysiological pr...

    Authors: Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Yiong Huak Chan, Lai Jiang, Joseph Therriault, Andrea L. Benedet, Monica Shin, Nagaendran Kandiah, Celia M. T. Greenwood, Pedro Rosa-Neto and Serge Gauthier

    Citation: Translational Neurodegeneration 2021 10:1

    Content type: Research

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  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J. Weiss, Yitzhak Tor, Jeffrey D. Esko and Nadia Soussi-Yanicostas

    Citation: Translational Neurodegeneration 2020 9:45

    Content type: Correction

    Published on:

    The original article was published in Translational Neurodegeneration 2018 7:6

  22. Deficits in synaptic transmission and plasticity are thought to contribute to the pathophysiology of Alzheimer’s disease (AD) and Parkinson’s disease (PD). Several brain stimulation techniques are currently av...

    Authors: Ti-Fei Yuan, Wei-Guang Li, Chencheng Zhang, Hongjiang Wei, Suya Sun, Nan-Jie Xu, Jun Liu and Tian-Le Xu

    Citation: Translational Neurodegeneration 2020 9:44

    Content type: Review

    Published on:

  23. Parkinson’s disease (PD) is diagnosed when patients exhibit bradykinesia with tremor and/or rigidity, and when these symptoms respond to dopaminergic medications. Yet in the last years there was a greater reco...

    Authors: Elisabeth Dinter, Theodora Saridaki, Leonie Diederichs, Heinz Reichmann and Björn H. Falkenburger

    Citation: Translational Neurodegeneration 2020 9:43

    Content type: Review

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  24. Accumulating reports have suggested that α-synuclein is involved in the pathogenesis of Alzheimer’s disease (AD). As the cerebrospinal fluid (CSF) α-synuclein has been suggested as a potential biomarker of AD,...

    Authors: Jie-Qiong Li, Yan-Lin Bi, Xue-Ning Shen, Hui-Fu Wang, Wei Xu, Chen-Chen Tan, Qiang Dong, Yan-Jiang Wang, Lan Tan and Jin-Tai Yu

    Citation: Translational Neurodegeneration 2020 9:41

    Content type: Research

    Published on:

  25. Mitochondria are the energy center of cell operations and are involved in physiological functions and maintenance of metabolic balance and homeostasis in the body. Alterations of mitochondrial function are ass...

    Authors: Chunhui Huang, Sen Yan and Zaijun Zhang

    Citation: Translational Neurodegeneration 2020 9:40

    Content type: Review

    Published on:

  26. Parkinson’s disease (PD) is characterized by motor deficits and a wide variety of non-motor symptoms. The age of onset, rate of disease progression and the precise profile of motor and non-motor symptoms displ...

    Authors: Christian U. von Linstow, Ziv Gan-Or and Patrik Brundin

    Citation: Translational Neurodegeneration 2020 9:39

    Content type: Review

    Published on:

  27. Misfolded oligomeric α-synuclein plays a pivotal role in the pathogenesis of α-synucleinopathies including Parkinson’s disease and multiple system atrophy, and its detection parallels activation of microglia a...

    Authors: Miguel Lemos, Serena Venezia, Violetta Refolo, Antonio Heras-Garvin, Sabine Schmidhuber, Armin Giese, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Gergana Galabova, Guenther Staffler, Gregor Karl Wenning and Nadia Stefanova

    Citation: Translational Neurodegeneration 2020 9:38

    Content type: Research

    Published on:

  28. Alzheimer’s disease (AD) immunotherapy with antibodies targeting amyloid-β (Aβ) has been extensively explored in clinical trials. The aim of this study was to study the long-term brain distribution of two radi...

    Authors: Tobias Gustavsson, Stina Syvänen, Paul O’Callaghan and Dag Sehlin

    Citation: Translational Neurodegeneration 2020 9:37

    Content type: Research

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  29. There is an urgent need to understand the pathways and processes underlying Alzheimer’s disease (AD) for early diagnosis and development of effective treatments. This study was aimed to investigate Alzheimer’s...

    Authors: Jin Xu, Giulia Bankov, Min Kim, Asger Wretlind, Jodie Lord, Rebecca Green, Angela Hodges, Abdul Hye, Dag Aarsland, Latha Velayudhan, Richard J. B. Dobson, Petroula Proitsi and Cristina Legido-Quigley

    Citation: Translational Neurodegeneration 2020 9:36

    Content type: Research

    Published on:

  30. Circular RNAs (circRNAs) are a type of covalently closed, single-stranded circular noncoding RNA that can affect the expression of many protein-coding genes. Growing evidence has shown that circRNAs play criti...

    Authors: Yuan Zhang, Yanfang Zhao, Ying Liu, Man Wang, Wanpeng Yu and Lei Zhang

    Citation: Translational Neurodegeneration 2020 9:35

    Content type: Review

    Published on:

  31. In recent years, many studies have investigated the correlations between Parkinson’s disease (PD) and vitamin D status, but the conclusion remains elusive. The present review focuses on the associations betwee...

    Authors: Lingling Lv, Xuling Tan, Xinke Peng, Rongrong Bai, Qile Xiao, Ting Zou, Jieqiong Tan, Hainan Zhang and Chunyu Wang

    Citation: Translational Neurodegeneration 2020 9:34

    Content type: Review

    Published on:

  32. Common and rare variants of guanosine triphosphate cyclohydrolase 1 (GCH1) gene may play important roles in Parkinson’s disease (PD). However, there is a lack of comprehensive analysis of GCH1 genotypes, especial...

    Authors: Hong-xu Pan, Yu-wen Zhao, Jun-pu Mei, Zheng-huan Fang, Yige Wang, Xun Zhou, Yang-jie Zhou, Rui Zhang, Kai-lin Zhang, Li Jiang, Qian Zeng, Yan He, Zheng Wang, Zhen-hua Liu, Qian Xu, Qi-ying Sun…

    Citation: Translational Neurodegeneration 2020 9:31

    Content type: Research

    Published on:

  33. Diseases and disorders with a chronic neuroinflammatory component are often linked with changes in brain metabolism. Among neurodegenerative disorders, people living with human immunodeficiency virus (HIV) and...

    Authors: Kalimuthusamy Natarajaseenivasan, Santhanam Shanmughapriya, Prema Velusamy, Matthew Sayre, Alvaro Garcia, Nestor Mas Gomez and Dianne Langford

    Citation: Translational Neurodegeneration 2020 9:32

    Content type: Research

    Published on:

  34. Progression of mild cognitive impairment (MCI) to Alzheimer’s disease (AD) dementia can be predicted by clinical features and a combination of biomarkers may increase the predictive power. In the present study...

    Authors: Aonan Zhao, Yuanyuan Li, Yi Yan, Yinghui Qiu, Binyin Li, Wei Xu, Ying Wang, Jun Liu and Yulei Deng

    Citation: Translational Neurodegeneration 2020 9:30

    Content type: Research

    Published on:

  35. Early morning off (EMO) is a common feature of Parkinson’s disease (PD). This study aimed to characterize its clinical features and develop a convenient and pragmatic self-assessment instrument in a Chinese na...

    Authors: Chao Han, Wei Mao, Jing An, Lifei Jiao and Piu Chan

    Citation: Translational Neurodegeneration 2020 9:29

    Content type: Research

    Published on:

  36. MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases. Overexpressed miRNAs play an important ro...

    Authors: Ki Yoon Kim, Yu Ri Kim, Kyung Won Choi, Mijung Lee, Somyung Lee, Wooseok Im, Je-Young Shin, Jin Young Kim, Yoon Ho Hong, Manho Kim, Jong-Il Kim and Jung-Joon Sung

    Citation: Translational Neurodegeneration 2020 9:23

    Content type: Research

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  37. The clinical presentations of frontotemporal dementia (FTD) are diverse and overlap with other neurological disorders. There are, as of today, no biomarkers in clinical practice for diagnosing the disorders. H...

    Authors: Julia Remnestål, Linn Öijerstedt, Abbe Ullgren, Jennie Olofsson, Sofia Bergström, Kim Kultima, Martin Ingelsson, Lena Kilander, Mathias Uhlén, Anna Månberg, Caroline Graff and Peter Nilsson

    Citation: Translational Neurodegeneration 2020 9:27

    Content type: Research

    Published on:

  38. In Alzheimer’s Disease (AD), about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways. Among them, the Ras and Rab Interactor 3(RIN3) is a guan...

    Authors: Ruinan Shen, Xiaobei Zhao, Lu He, Yongbo Ding, Wei Xu, Suzhen Lin, Savannah Fang, Wanlin Yang, Kijung Sung, Brian Spencer, Robert A. Rissman, Ming Lei, Jianqing Ding and Chengbiao Wu

    Citation: Translational Neurodegeneration 2020 9:26

    Content type: Research

    Published on:

  39. An amendment to this paper has been published and can be accessed via the original article.

    Authors: William R. Swindell, Krzysztof Bojanowski, Mark S. Kindy, Raymond M. W. Chau and Dorothy Ko

    Citation: Translational Neurodegeneration 2020 9:24

    Content type: Correction

    Published on:

    The original article was published in Translational Neurodegeneration 2018 7:30

  40. Alzheimer’s and Parkinson’s diseases are the most prevalent neurodegenerative disorders. Their etiologies are idiopathic, and treatments are symptomatic and orientated towards cognitive or motor deficits. Neur...

    Authors: Isabel Ubeda-Bañon, Daniel Saiz-Sanchez, Alicia Flores-Cuadrado, Ernesto Rioja-Corroto, Melania Gonzalez-Rodriguez, Sandra Villar-Conde, Veronica Astillero-Lopez, Juan Pablo Cabello-de la Rosa, Maria Jose Gallardo-Alcañiz, Julia Vaamonde-Gamo, Fernanda Relea-Calatayud, Lucia Gonzalez-Lopez, Alicia Mohedano-Moriano, Alberto Rabano and Alino Martinez-Marcos

    Citation: Translational Neurodegeneration 2020 9:22

    Content type: Review

    Published on:

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