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  1. The central nervous system (CNS) is integrated by glial and neuronal cells, and both release extracellular vesicles (EVs) that participate in CNS homeostasis. EVs could be one of the best candidates to operate...

    Authors: Rocío del Carmen Bravo-Miana, Jone Karmele Arizaga-Echebarria and David Otaegui
    Citation: Translational Neurodegeneration 2024 13:32
  2. TDP-43 proteinopathies are a heterogeneous group of neurodegenerative disorders that share the presence of aberrant, misfolded and mislocalized deposits of the protein TDP-43, as in the case of amyotrophic lat...

    Authors: Juan I. López-Carbonero, Irene García-Toledo, Laura Fernández-Hernández, Pablo Bascuñana, María J. Gil-Moreno, Jordi A. Matías-Guiu and Silvia Corrochano
    Citation: Translational Neurodegeneration 2024 13:29
  3. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motor neurons, resulting in global health burden and limited post-diagnosis life expectancy. Althou...

    Authors: Miaodan Huang, Yong U. Liu, Xiaoli Yao, Dajiang Qin and Huanxing Su
    Citation: Translational Neurodegeneration 2024 13:28
  4. Authors: Yi-Ting Wang, Nicholas J. Ashton, Stijn Servaes, Johanna Nilsson, Marcel S. Woo, Tharick A. Pascoal, Cécile Tissot, Nesrine Rahmouni, Joseph Therriault, Firoza Lussier, Mira Chamoun, Serge Gauthier, Ann Brinkmalm, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto…
    Citation: Translational Neurodegeneration 2024 13:27
  5. The use of biomarker-led clinical trial designs has been transformative for investigating amyloid-targeting therapies for Alzheimer’s disease (AD). The designs have ensured the correct selection of patients on...

    Authors: Lewis K. Penny, Richard Lofthouse, Mohammad Arastoo, Andy Porter, Soumya Palliyil, Charles R. Harrington and Claude M. Wischik
    Citation: Translational Neurodegeneration 2024 13:25
  6. Adult neurogenesis occurs in the subventricular zone (SVZ) and the subgranular zone of the dentate gyrus in the hippocampus. The neuronal stem cells in these two neurogenic niches respond differently to variou...

    Authors: Dongfang Jiang, Hongmei Liu, Tingting Li, Song Zhao, Keyan Yang, Fuwen Yao, Bo Zhou, Haiping Feng, Sijia Wang, Jiaqi Shen, Jinglan Tang, Yu-Xin Zhang, Yun Wang, Caixia Guo and Tie-Shan Tang
    Citation: Translational Neurodegeneration 2024 13:24
  7. Mitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome. They are closely related to the physiology and pathology of ...

    Authors: Nanshan Song, Shuyuan Mei, Xiangxu Wang, Gang Hu and Ming Lu
    Citation: Translational Neurodegeneration 2024 13:23
  8. The renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues and organs, including the brain, have a local paracrine RAS...

    Authors: Jose Luis Labandeira-Garcia, Carmen M. Labandeira, Maria J. Guerra and Ana I. Rodriguez-Perez
    Citation: Translational Neurodegeneration 2024 13:22
  9. Huntington's disease (HD) is a devastating neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein, resulting from a CAG repeat expansion in the huntingtin gene HTT. HD is charact...

    Authors: Russell G. Wells, Lee E. Neilson, Andrew W. McHill and Amie L. Hiller
    Citation: Translational Neurodegeneration 2024 13:17
  10. Authors: Alessandra Bigi, Giulia Fani, Valentina Bessi, Liliana Napolitano, Silvia Bagnoli, Assunta Ingannato, Lorenzo Neri, Roberta Cascella, Paolo Matteini, Sandro Sorbi, Benedetta Nacmias, Cristina Cecchi and Fabrizio Chiti
    Citation: Translational Neurodegeneration 2024 13:14
  11. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate the LRRK2 kinase activity, making LRRK2 kinase inhibitors an attractive th...

    Authors: Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard L. Li, Cheryl E. G. Leyns, Lakshmi Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M. Y. Lee, Dani S. Bassett and Michael X. Henderson
    Citation: Translational Neurodegeneration 2024 13:13
  12. The aetiologies and origins of neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD), are complex and multifa...

    Authors: Yuan-Yuan Ma, Xin Li, Jin-Tai Yu and Yan-Jiang Wang
    Citation: Translational Neurodegeneration 2024 13:12
  13. It is now realized that Parkinson’s disease (PD) pathology extends beyond the substantia nigra, affecting both central and peripheral nervous systems, and exhibits a variety of non-motor symptoms often precedi...

    Authors: Emmanouela Leandrou, Ioanna Chalatsa, Dimitrios Anagnostou, Christina Machalia, Maria Semitekolou, Vicky Filippa, Manousos Makridakis, Antonia Vlahou, Ema Anastasiadou, Kostas Vekrellis and Evangelia Emmanouilidou
    Citation: Translational Neurodegeneration 2024 13:11
  14. Degeneration of the locus coeruleus (LC) noradrenergic system contributes to clinical symptoms in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Diffusion magnetic resonance imaging (MRI) has the poten...

    Authors: Chen-Pei Lin, Irene Frigerio, John G. J. M. Bol, Maud M. A. Bouwman, Alex J. Wesseling, Martin J. Dahl, Annemieke J. M. Rozemuller, Ysbrand D. van der Werf, Petra J. W. Pouwels, Wilma D. J. van de Berg and Laura E. Jonkman
    Citation: Translational Neurodegeneration 2024 13:9
  15. Little is known about the impact of the COVID-19 pandemic on patients with Parkinson’s disease (PD) at different stages of the pandemic. This study aims to assess the lives and disease status of PD patients du...

    Authors: Pei Huang, Yu-Yan Tan, Biao Chen, Hui-Fang Shang, Li-Juan Wang, Chun-Feng Liu, Ling Chen, Ying Chang, Han Wang, Xue-Lian Wang, Xiao-Guang Lei, Li-Fen Yao, Yang Yu, Zheng Ye, Hai-Bo Chen and Sheng-Di Chen
    Citation: Translational Neurodegeneration 2024 13:8
  16. Ageing is a crucial risk factor for Alzheimer’s disease (AD) and is characterised by systemic changes in both intracellular and extracellular microenvironments that affect the entire body instead of a single o...

    Authors: Yuqing Liu, Yejun Tan, Zheyu Zhang, Min Yi, Lemei Zhu and Weijun Peng
    Citation: Translational Neurodegeneration 2024 13:7
  17. Neurodegenerative disorders present complex pathologies characterized by various interconnected factors, including the aggregation of misfolded proteins, oxidative stress, neuroinflammation and compromised blo...

    Authors: Arazu Sharif, John Mamo, Virginie Lam, Hani Al-Salami, Armin Mooranian, Gerald F. Watts, Roger Clarnette, Giuseppe Luna and Ryu Takechi
    Citation: Translational Neurodegeneration 2024 13:6
  18. Microglia-mediated neuroinflammation in Alzheimer’s disease (AD) is not only a response to pathophysiological events, but also plays a causative role in neurodegeneration. Cytoplasmic cysteinyl-tRNA synthetase...

    Authors: Xiu-Hong Qi, Peng Chen, Yue-Ju Wang, Zhe-Ping Zhou, Xue-Chun Liu, Hui Fang, Chen-Wei Wang, Ji Liu, Rong-Yu Liu, Han-Kui Liu, Zhen-Xin Zhang and Jiang-Ning Zhou
    Citation: Translational Neurodegeneration 2024 13:3
  19. Alzheimer's disease (AD) is considered to have a multifactorial etiology. The hallmark of AD is progressive neurodegeneration, which is characterized by the deepening loss of memory and a high mortality rate i...

    Authors: Hoda M. Gebril, Aravind Aryasomayajula, Mariana Reis Nogueira de Lima, Kathryn E. Uhrich and Prabhas V. Moghe
    Citation: Translational Neurodegeneration 2024 13:2
  20. Alzheimer's disease (AD) is a neurodegenerative disorder and the predominant type of dementia worldwide. It is characterized by the progressive and irreversible decline of cognitive functions. In addition to t...

    Authors: Min Zhang, Zhan Zhang, Honghong Li, Yuting Xia, Mengdan Xing, Chuan Xiao, Wenbao Cai, Lulu Bu, Yi Li, Tae-Eun Park, Yamei Tang, Xiaojing Ye and Wei-Jye Lin
    Citation: Translational Neurodegeneration 2024 13:1
  21. The γ-aminobutyric acid (GABA) hypothesis posits a role of GABA deficiency in the central nervous system in the pathogenesis and progression of essential tremor (ET). However, the specific causative factor for...

    Authors: Hao-Jie Zhong, Si-Qi Wang, Ruo-Xin Zhang, Yu-Pei Zhuang, Longyan Li, Shuo-Zhao Yi, Ying Li, Lei Wu, Yu Ding, Jumei Zhang, Xinqiang Xie, Xing-Xiang He and Qingping Wu
    Citation: Translational Neurodegeneration 2023 12:58
  22. TDP-43 proteinopathies represent a spectrum of neurological disorders, anchored clinically on either end by amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). The ALS–FTD spectrum exhib...

    Authors: Ting Shen, Jacob W. Vogel, Jeffrey Duda, Jeffrey S. Phillips, Philip A. Cook, James Gee, Lauren Elman, Colin Quinn, Defne A. Amado, Michael Baer, Lauren Massimo, Murray Grossman, David J. Irwin and Corey T. McMillan
    Citation: Translational Neurodegeneration 2023 12:57
  23. Cognitive decline in Alzheimer’s disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV b...

    Authors: Carolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R. Joe, Rana Rais, Norman J. Haughey, Dimitrios Kapogiannis…
    Citation: Translational Neurodegeneration 2023 12:56
  24. Deep brain stimulation (DBS) is a well-established and effective treatment for patients with advanced Parkinson's disease (PD), yet its underlying mechanisms remain enigmatic. Optogenetics, primarily conducted...

    Authors: Wenying Xu, Jie Wang, Xin-Ni Li, Jingxue Liang, Lu Song, Yi Wu, Zhenguo Liu, Bomin Sun and Wei-Guang Li
    Citation: Translational Neurodegeneration 2023 12:55
  25. Synaptic degeneration occurs in the early stage of Alzheimer's disease (AD) before devastating symptoms, strongly correlated with cognitive decline. Circular RNAs (circRNAs) are abundantly enriched in neural t...

    Authors: Xiong Wang, Jiazhao Xie, Lu Tan, Yanjun Lu, Na Shen, Jiaoyuan Li, Hui Hu, Huijun Li, Xiaoguang Li and Liming Cheng
    Citation: Translational Neurodegeneration 2023 12:53
  26. ClinicalTrials.gov Identifier: NCT05821153, Registered April 20 2023, Retrospectively registered, https://​classic.​clinicaltrials.​gov/​ct2/​show/​NCT05821153

    Authors: Alireza Faridar, Abdulmunaim M. Eid, Aaron D. Thome, Weihua Zhao, David R. Beers, Maria B. Pascual, Mohammad O. Nakawah, Gustavo C. Roman, Charles S. Davis, Michael Grundman, Joseph C. Masdeu and Stanley H. Appel
    Citation: Translational Neurodegeneration 2023 12:54
  27. Oligodendrocyte progenitor cells (OPCs) play pivotal roles in myelin formation and phagocytosis, communicating with neighboring cells and contributing to the integrity of the blood–brain barrier (BBB). However...

    Authors: Peibin Zou, Chongyun Wu, Timon Cheng-Yi Liu, Rui Duan and Luodan Yang
    Citation: Translational Neurodegeneration 2023 12:52
  28. Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark of Alzheimer’s disease (AD). However, mouse models imitating AD-exclusive neuronal tau pathologies are lacking.

    Authors: Yang Gao, Yuying Wang, Huiyang Lei, Zhendong Xu, Shihong Li, Haitao Yu, Jiazhao Xie, Zhentao Zhang, Gongping Liu, Yao Zhang, Jie Zheng and Jian-Zhi Wang
    Citation: Translational Neurodegeneration 2023 12:51

    The Correction to this article has been published in Translational Neurodegeneration 2024 13:5

  29. Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly, resulting in gradual destruction of cognitive abilities. Research on the development of various AD treatments is underway;...

    Authors: Hyunkyung Mo, Juryun Kim, Jennifer Yejean Kim, Jang Woon Kim, Heeju Han, Si Hwa Choi, Yeri Alice Rim and Ji Hyeon Ju
    Citation: Translational Neurodegeneration 2023 12:50
  30. Cognitive impairment is a multifactorial and multi-step pathological process that places a heavy burden on patients and the society. Neuroinflammation is one of the main factors leading to cognitive impairment...

    Authors: Yi Xu, Yanling Yang, Xi Chen, Danling Jiang, Fei Zhang, Yao Guo, Bin Hu, Guohai Xu, Shengliang Peng, Lidong Wu and Jialing Hu
    Citation: Translational Neurodegeneration 2023 12:49
  31. Microglia, the resident immune cells of the brain, are increasingly implicated in the regulation of brain health and disease. Microglia perform multiple functions in the central nervous system, including surve...

    Authors: Izabela Lepiarz-Raba, Ismail Gbadamosi, Roberta Florea, Rosa Chiara Paolicelli and Ali Jawaid
    Citation: Translational Neurodegeneration 2023 12:48
  32. Amyotrophic lateral sclerosis (ALS) is a poorly treated multifactorial neurodegenerative disease associated with multiple cell types and subcellular organelles. As with other multifactorial diseases, it is lik...

    Authors: Peter J. Richardson, Daniel P. Smith, Alex de Giorgio, Xenia Snetkov, Joshua Almond-Thynne, Sara Cronin, Richard J. Mead, Christopher J. McDermott and Pamela J. Shaw
    Citation: Translational Neurodegeneration 2023 12:47
  33. In order to dissect amyotrophic lateral sclerosis (ALS), a multigenic, multifactorial, and progressive neurodegenerative disease with heterogeneous clinical presentations, researchers have generated numerous a...

    Authors: Longhong Zhu, Shihua Li, Xiao-Jiang Li and Peng Yin
    Citation: Translational Neurodegeneration 2023 12:46
  34. Friedreich ataxia (FRDA) is a rare genetic multisystem disorder caused by a pathological GAA trinucleotide repeat expansion in the FXN gene. The numerous drawbacks of historical cellular and rodent models of FRDA...

    Authors: Saumya Maheshwari, Gabriela Vilema-Enríquez and Richard Wade-Martins
    Citation: Translational Neurodegeneration 2023 12:45
  35. A pathological feature of Parkinson’s disease (PD) is the progressive loss of dopaminergic neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD brains. DA is the neurotransmi...

    Authors: Zhi Dong Zhou, Ling Xiao Yi, Dennis Qing Wang, Tit Meng Lim and Eng King Tan
    Citation: Translational Neurodegeneration 2023 12:44
  36. Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease, affect millions of people worldwide. Tremendous efforts have been put into...

    Authors: Zhengzhe Li, Xiaoling Wang, Xiaoxing Wang, Xiaomei Yi, Yin Kwan Wong, Jiyang Wu, Fangfang Xie, Die Hu, Qi Wang, Jigang Wang and Tianyu Zhong
    Citation: Translational Neurodegeneration 2023 12:43
  37. There is a need for biomarkers to support an accurate diagnosis of Parkinson’s disease (PD). Cerebrospinal fluid (CSF) has been a successful biofluid for finding neurodegenerative biomarkers, and modern highly...

    Authors: Wojciech Paslawski, Shervin Khosousi, Ellen Hertz, Ioanna Markaki, Adam Boxer and Per Svenningsson
    Citation: Translational Neurodegeneration 2023 12:42

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