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  1. Although many causative genes have been uncovered in recent years, genetic diagnosis is still missing for approximately 50% of autosomal recessive cerebellar ataxia (ARCA) patients. Few studies have been perfo...

    Authors: Hao-Ling Cheng, Ya-Ru Shao, Yi Dong, Hai-Lin Dong, Lu Yang, Yin Ma, Ying Shen and Zhi-Ying Wu

    Citation: Translational Neurodegeneration 2021 10:40

    Content type: Research

    Published on:

  2. Parkinson’s disease (PD) is a common neurodegenerative disorder that primarily affects the elderly. While the etiology of PD is likely multifactorial with the involvement of genetic, environmental, aging and o...

    Authors: Changjing Wang, Tongtong Yang, Meiyu Liang, Junxia Xie and Ning Song

    Citation: Translational Neurodegeneration 2021 10:39

    Content type: Review

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  3. Amyloid-β (Aβ) immunotherapy is a promising therapeutic strategy in the fight against Alzheimer’s disease (AD). A number of monoclonal antibodies have entered clinical trials for AD. Some of them have failed d...

    Authors: Fadi Rofo, Jos Buijs, Ronny Falk, Ken Honek, Lars Lannfelt, Anna M. Lilja, Nicole G. Metzendorf, Tobias Gustavsson, Dag Sehlin, Linda Söderberg and Greta Hultqvist

    Citation: Translational Neurodegeneration 2021 10:38

    Content type: Research

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  4. New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promisi...

    Authors: Neus Barranco, Virginia Plá, Daniel Alcolea, Irene Sánchez-Domínguez, Reiner Fischer-Colbrie, Isidro Ferrer, Alberto Lleó and Fernando Aguado

    Citation: Translational Neurodegeneration 2021 10:37

    Content type: Research

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  5. Alzheimer’s disease (AD) is the most common cause of dementia, affecting approximately 40 million people worldwide. The ineffectiveness of the available pharmacological treatments against AD has fostered resea...

    Authors: Francisca Monteiro, Ioannis Sotiropoulos, Óscar Carvalho, Nuno Sousa and Filipe S. Silva

    Citation: Translational Neurodegeneration 2021 10:36

    Content type: Review

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  6. There is increasing evidence that amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease impacting large-scale brain networks. However, it is still unclear which structural networks are...

    Authors: Wenbin Li, Qianqian Wei, Yanbing Hou, Du Lei, Yuan Ai, Kun Qin, Jing Yang, Graham J. Kemp, Huifang Shang and Qiyong Gong

    Citation: Translational Neurodegeneration 2021 10:35

    Content type: Research

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  7. β Amyloid (Aβ)-mediated neuronal hyperactivity, a key feature of the early stage of Alzheimer’s disease (AD), is recently proposed to be initiated by the suppression of glutamate reuptake. Nevertheless, the un...

    Authors: Yifei Bao, Xin Yang, Yi Fu, Zhengyan Li, Ru Gong and Wei Lu

    Citation: Translational Neurodegeneration 2021 10:34

    Content type: Research

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  8. Advancing age is a major risk factor for Alzheimer’s disease (AD). This raises the question of whether AD biology mechanistically diverges from aging biology or alternatively represents exaggerated aging. Corr...

    Authors: Heather M. Wilkins and Russell H. Swerdlow

    Citation: Translational Neurodegeneration 2021 10:33

    Content type: Review

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  9. The combinatorial effect of multiple genetic factors calculated as a polygenic risk score (PRS) has been studied to predict disease progression to Alzheimer’s disease (AD) from mild cognitive impairment (MCI)....

    Authors: Jung-Min Pyun, Young Ho Park, Keon-Joo Lee, SangYun Kim, Andrew J. Saykin and Kwangsik Nho

    Citation: Translational Neurodegeneration 2021 10:32

    Content type: Research

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  10. Interventional trials in amyotrophic lateral sclerosis (ALS) suffer from the heterogeneity of the disease as it considerably reduces statistical power. We asked if blood neurofilament light chains (NfL) could ...

    Authors: Simon Witzel, Felix Frauhammer, Petra Steinacker, David Devos, Pierre-François Pradat, Vincent Meininger, Steffen Halbgebauer, Patrick Oeckl, Joachim Schuster, Simon Anders, Johannes Dorst, Markus Otto and Albert C. Ludolph

    Citation: Translational Neurodegeneration 2021 10:31

    Content type: Research

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  11. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower motor neurons, leading to paralysis and eventually death. Symptomatic treatments such as inhibition...

    Authors: Xiaojiao Xu, Dingding Shen, Yining Gao, Qinming Zhou, You Ni, Huanyu Meng, Hongqin Shi, Weidong Le, Shengdi Chen and Sheng Chen

    Citation: Translational Neurodegeneration 2021 10:29

    Content type: Review

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  12. The aim of this study was to assess and compare the diagnostic utility of a new diagnostic criteria for amyotrophic lateral sclerosis (ALS), abbreviated as the ‘Gold Coast Criteria’, with the revised El Escori...

    Authors: Dongchao Shen, Xunzhe Yang, Yanying Wang, Di He, Xiaohan Sun, Zhengyi Cai, Jinyue Li, Mingsheng Liu and Liying Cui

    Citation: Translational Neurodegeneration 2021 10:28

    Content type: Research

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  13. Alzheimer’s disease (AD) is a neurodegenerative disease that currently cannot be cured by any drug or intervention, due to its complicated pathogenesis. Current animal and cellular models of AD are unable to m...

    Authors: Feng-Chen Bi, Xin-He Yang, Xiao-Yu Cheng, Wen-Bin Deng, Xiao-Li Guo, Hui Yang, Yin Wang, Juan Li and Yao Yao

    Citation: Translational Neurodegeneration 2021 10:27

    Content type: Review

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  14. Blood-based test for predicting disease progression and early diagnosis of Parkinson’s disease (PD) is an unmet need in the clinic. The profiles of microRNAs (miRNAs) are regarded as potential diagnostic bioma...

    Authors: Shulei He, Lu Huang, Ci Shao, Tiejian Nie, Li Xia, Bozhou Cui, Fangfang Lu, Lin Zhu, Bolin Chen and Qian Yang

    Citation: Translational Neurodegeneration 2021 10:25

    Content type: Research

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  15. Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by a gradual, insidious and progressive loss of language abilities, with naming difficulties being an early and persistent impair...

    Authors: Ilaria Pagnoni, Elena Gobbi, Enrico Premi, Barbara Borroni, Giuliano Binetti, Maria Cotelli and Rosa Manenti

    Citation: Translational Neurodegeneration 2021 10:24

    Content type: Review

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  16. Gait problems are an important symptom in Parkinson’s disease (PD), a progressive neurodegenerative disease. Transcranial direct current stimulation (tDCS) is a neuromodulatory intervention that can modulate c...

    Authors: Fateme Pol, Mohammad Ali Salehinejad, Hamzeh Baharlouei and Michael A. Nitsche

    Citation: Translational Neurodegeneration 2021 10:22

    Content type: Review

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  17. Accumulation of alpha-synuclein (α-syn) is a main pathological hallmark of Parkinson’s and related diseases, which are collectively known as synucleinopathies. Growing evidence has supported that the same prot...

    Authors: Di Liu, Jian-Jun Guo, Ji-Hui Su, Alexander Svanbergsson, Lin Yuan, Caroline Haikal, Wen Li, Gunnar Gouras and Jia-Yi Li

    Citation: Translational Neurodegeneration 2021 10:20

    Content type: Research

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  18. Mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s disease (PD), and several genes linked to familial PD, including PINK1 (encoding PTEN-induced putative kinase 1 [PINK1]) and PAR...

    Authors: Kai Yu Ma, Michiel R. Fokkens, Fulvio Reggiori, Muriel Mari and Dineke S. Verbeek

    Citation: Translational Neurodegeneration 2021 10:19

    Content type: Research

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  19. The aggregation of amyloid β (Aβ) is central in the pathogenesis of Alzheimer’s disease (AD). Recently it has been shown that specifically, larger, Thioflavin T-binding Aβ aggregates are associated with increa...

    Authors: Mari Aksnes, Hans Christian D. Aass, Ann Tiiman, Trine Holt Edwin, Lars Terenius, Nenad Bogdanović, Vladana Vukojević and Anne-Brita Knapskog

    Citation: Translational Neurodegeneration 2021 10:18

    Content type: Research

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  20. Increased catabolism has recently been recognized as a clinical manifestation of amyotrophic lateral sclerosis (ALS). The hypothalamic systems have been shown to be involved in the metabolic dysfunction in ALS...

    Authors: David Bayer, Stefano Antonucci, Hans-Peter Müller, Rami Saad, Luc Dupuis, Volker Rasche, Tobias M. Böckers, Albert C. Ludolph, Jan Kassubek and Francesco Roselli

    Citation: Translational Neurodegeneration 2021 10:17

    Content type: Research

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  21. Precursor messenger RNA (pre-mRNA) splicing is a fundamental step in eukaryotic gene expression that systematically removes non-coding regions (introns) and ligates coding regions (exons) into a continuous mes...

    Authors: Dunhui Li, Craig Stewart McIntosh, Frank Louis Mastaglia, Steve Donald Wilton and May Thandar Aung-Htut

    Citation: Translational Neurodegeneration 2021 10:16

    Content type: Review

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  22. Animal models provide an opportunity to assess the optimal treatment way and the underlying mechanisms of direct clinical application of adipose-derived stem cells (ADSCs). Previous studies have evaluated the ...

    Authors: Keya Li, Xinyue Li, Guiying Shi, Xuepei Lei, Yiying Huang, Lin Bai and Chuan Qin

    Citation: Translational Neurodegeneration 2021 10:14

    Content type: Review

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  23. The mechanisms underlying lesions of dopaminergic (DA) neurons, an essential pathology of Parkinson’s disease (PD), are largely unknown, although oxidative stress is recognized as a key factor. We have previou...

    Authors: Liangqin Shi, Yazhou Lin, Yucheng Jiao, Seth A. Herr, Jonathan Tang, Edmond Rogers, Zhengli Chen and Riyi Shi

    Citation: Translational Neurodegeneration 2021 10:13

    Content type: Research

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  24. Currently, there is no cure for Alzheimer’s disease (AD). Therapeutics that can modify the early stage of AD are urgently needed. Recent studies have shown that the pathogenesis of AD is closely regulated by a...

    Authors: Ju Wang, Hui-Jie Hu, Zi-Kai Liu, Jing-Jing Liu, Shan-Shan Wang, Qing Cheng, Hong-Zhuan Chen and Mingke Song

    Citation: Translational Neurodegeneration 2021 10:12

    Content type: Research

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  25. The development of in vivo biomarkers of Alzheimer’s disease (AD) has advanced the diagnosis of AD from a clinical syndrome to a biological construct. The preclinical stage of AD continuum is defined by the id...

    Authors: Kok Pin Ng, Hui Chiew, Pedro Rosa-Neto, Nagaendran Kandiah, Zahinoor Ismail and Serge Gauthier

    Citation: Translational Neurodegeneration 2021 10:11

    Content type: Review

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  26. A lack of convenient and reliable biomarkers for diagnosis and prognosis is a common challenge for neurodegenerative diseases such as Alzheimer’s disease (AD). Recent advancement in ultrasensitive protein assa...

    Authors: Xulong Ding, Shuting Zhang, Lijun Jiang, Lu Wang, Tao Li and Peng Lei

    Citation: Translational Neurodegeneration 2021 10:10

    Content type: Review

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  27. α-Synuclein has been studied as a potential biomarker for Parkinson’s disease (PD) with no concluding results. Accordingly, there is an urgent need to find out reliable specific biomarkers for PD. GPR37 is an ...

    Authors: Xavier Morató, Paula Garcia-Esparcia, Josep Argerich, Franc Llorens, Inga Zerr, Wojciech Paslawski, Eva Borràs, Eduard Sabidó, Ulla E. Petäjä-Repo, Víctor Fernández-Dueñas, Isidro Ferrer, Per Svenningsson and Francisco Ciruela

    Citation: Translational Neurodegeneration 2021 10:8

    Content type: Research

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  28. Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes. Paroxysmal kinesigenic dyskinesia (PKD) is the most common typ...

    Authors: Li Cao, Xiaojun Huang, Ning Wang, Zhiying Wu, Cheng Zhang, Weihong Gu, Shuyan Cong, Jianhua Ma, Ling Wei, Yanchun Deng, Qi Fang, Qi Niu, Jin Wang, Zhaoxia Wang, You Yin, Jinyong Tian…

    Citation: Translational Neurodegeneration 2021 10:7

    Content type: Review

    Published on:

  29. As the most common form of dementia, Alzheimer’s disease (AD) is characterized by progressive cognitive impairments and constitutes a major social burden. Currently, the invasiveness and high costs of tests ha...

    Authors: Ying Zhang, Yanjiang Wang, Ce Shi, Meixiao Shen and Fan Lu

    Citation: Translational Neurodegeneration 2021 10:6

    Content type: Review

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  30. The familial form of Parkinson’s disease (PD) is linked to mutations in specific genes. The mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active...

    Authors: Iryna Kamienieva, Jerzy Duszyński and Joanna Szczepanowska

    Citation: Translational Neurodegeneration 2021 10:5

    Content type: Review

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  31. Current therapies for Parkinson’s disease (PD) are palliative, of which the levodopa/carbidopa therapy remains the primary choice but is unable to modulate the progression of neurodegeneration. Due to the comp...

    Authors: Tapan Behl, Gagandeep Kaur, Ovidiu Fratila, Camelia Buhas, Claudia Teodora Judea-Pusta, Nicoleta Negrut, Cristiana Bustea and Simona Bungau

    Citation: Translational Neurodegeneration 2021 10:4

    Content type: Review

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  32. Accumulating evidence has suggested that the pathological changes in amyotrophic lateral sclerosis (ALS) are not only confined to the central nervous system but also occur in the peripheral circulating system....

    Authors: Yangfan Cheng, Yongping Chen and Huifang Shang

    Citation: Translational Neurodegeneration 2021 10:3

    Content type: Review

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  33. Neuropsychiatric symptoms (NPS) are increasingly recognized as early non-cognitive manifestations in the Alzheimer’s disease (AD) continuum. However, the role of NPS as an early marker of pathophysiological pr...

    Authors: Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Yiong Huak Chan, Lai Jiang, Joseph Therriault, Andrea L. Benedet, Monica Shin, Nagaendran Kandiah, Celia M. T. Greenwood, Pedro Rosa-Neto and Serge Gauthier

    Citation: Translational Neurodegeneration 2021 10:1

    Content type: Research

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  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J. Weiss, Yitzhak Tor, Jeffrey D. Esko and Nadia Soussi-Yanicostas

    Citation: Translational Neurodegeneration 2020 9:45

    Content type: Correction

    Published on:

    The original article was published in Translational Neurodegeneration 2018 7:6

  35. Deficits in synaptic transmission and plasticity are thought to contribute to the pathophysiology of Alzheimer’s disease (AD) and Parkinson’s disease (PD). Several brain stimulation techniques are currently av...

    Authors: Ti-Fei Yuan, Wei-Guang Li, Chencheng Zhang, Hongjiang Wei, Suya Sun, Nan-Jie Xu, Jun Liu and Tian-Le Xu

    Citation: Translational Neurodegeneration 2020 9:44

    Content type: Review

    Published on:

  36. Parkinson’s disease (PD) is diagnosed when patients exhibit bradykinesia with tremor and/or rigidity, and when these symptoms respond to dopaminergic medications. Yet in the last years there was a greater reco...

    Authors: Elisabeth Dinter, Theodora Saridaki, Leonie Diederichs, Heinz Reichmann and Björn H. Falkenburger

    Citation: Translational Neurodegeneration 2020 9:43

    Content type: Review

    Published on:

  37. Accumulating reports have suggested that α-synuclein is involved in the pathogenesis of Alzheimer’s disease (AD). As the cerebrospinal fluid (CSF) α-synuclein has been suggested as a potential biomarker of AD,...

    Authors: Jie-Qiong Li, Yan-Lin Bi, Xue-Ning Shen, Hui-Fu Wang, Wei Xu, Chen-Chen Tan, Qiang Dong, Yan-Jiang Wang, Lan Tan and Jin-Tai Yu

    Citation: Translational Neurodegeneration 2020 9:41

    Content type: Research

    Published on:

  38. Mitochondria are the energy center of cell operations and are involved in physiological functions and maintenance of metabolic balance and homeostasis in the body. Alterations of mitochondrial function are ass...

    Authors: Chunhui Huang, Sen Yan and Zaijun Zhang

    Citation: Translational Neurodegeneration 2020 9:40

    Content type: Review

    Published on:

  39. Parkinson’s disease (PD) is characterized by motor deficits and a wide variety of non-motor symptoms. The age of onset, rate of disease progression and the precise profile of motor and non-motor symptoms displ...

    Authors: Christian U. von Linstow, Ziv Gan-Or and Patrik Brundin

    Citation: Translational Neurodegeneration 2020 9:39

    Content type: Review

    Published on:

  40. Misfolded oligomeric α-synuclein plays a pivotal role in the pathogenesis of α-synucleinopathies including Parkinson’s disease and multiple system atrophy, and its detection parallels activation of microglia a...

    Authors: Miguel Lemos, Serena Venezia, Violetta Refolo, Antonio Heras-Garvin, Sabine Schmidhuber, Armin Giese, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Gergana Galabova, Guenther Staffler, Gregor Karl Wenning and Nadia Stefanova

    Citation: Translational Neurodegeneration 2020 9:38

    Content type: Research

    Published on:

  41. There is an urgent need to understand the pathways and processes underlying Alzheimer’s disease (AD) for early diagnosis and development of effective treatments. This study was aimed to investigate Alzheimer’s...

    Authors: Jin Xu, Giulia Bankov, Min Kim, Asger Wretlind, Jodie Lord, Rebecca Green, Angela Hodges, Abdul Hye, Dag Aarsland, Latha Velayudhan, Richard J. B. Dobson, Petroula Proitsi and Cristina Legido-Quigley

    Citation: Translational Neurodegeneration 2020 9:36

    Content type: Research

    Published on:

  42. Circular RNAs (circRNAs) are a type of covalently closed, single-stranded circular noncoding RNA that can affect the expression of many protein-coding genes. Growing evidence has shown that circRNAs play criti...

    Authors: Yuan Zhang, Yanfang Zhao, Ying Liu, Man Wang, Wanpeng Yu and Lei Zhang

    Citation: Translational Neurodegeneration 2020 9:35

    Content type: Review

    Published on:

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