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  1. Neurological disorders (NDs) are characterized by progressive neuronal dysfunction leading to synaptic failure, cognitive impairment, and motor injury. Among these diseases, Alzheimer's disease (AD), Parkinson...

    Authors: Margrethe A. Olesen, Francisca Villavicencio-Tejo and Rodrigo A. Quintanilla
    Citation: Translational Neurodegeneration 2022 11:36
  2. Neuronal dysfunction and degeneration linked to α-synuclein (αS) pathology is thought to be responsible for the progressive nature of Parkinson’s disease and related dementia with Lewy bodies. Studies have ind...

    Authors: Scott C. Vermilyea, Anne Christensen, Joyce Meints, Balvindar Singh, Héctor Martell-Martínez, Md. Razaul Karim and Michael K. Lee
    Citation: Translational Neurodegeneration 2022 11:34
  3. Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded aggregates accumulating. The neurodegenerative process is mediated by numerous metabolic pathways, most of which lead to apo...

    Authors: Kareem Khalaf, Paolo Tornese, Antoniangela Cocco and Alberto Albanese
    Citation: Translational Neurodegeneration 2022 11:33
  4. Accumulation of impaired mitochondria and energy metabolism disorders are non-negligible features of both aging and age-related neurodegeneration, including Alzheimer’s disease (AD). A growing number of studie...

    Authors: Kuan Zeng, Xuan Yu, Yacoubou Abdoul Razak Mahaman, Jian-Zhi Wang, Rong Liu, Yi Li and Xiaochuan Wang
    Citation: Translational Neurodegeneration 2022 11:32
  5. Axonal degeneration and defects in neuromuscular neurotransmission represent a pathological hallmark in spinal muscular atrophy (SMA) and other forms of motoneuron disease. These pathological changes do not on...

    Authors: Chunchu Deng, Sebastian Reinhard, Luisa Hennlein, Janna Eilts, Stefan Sachs, Sören Doose, Sibylle Jablonka, Markus Sauer, Mehri Moradi and Michael Sendtner
    Citation: Translational Neurodegeneration 2022 11:31
  6. The molecular heterogeneity of Alzheimer’s amyloid-β (Aβ) deposits extends well beyond the classic Aβ1-40/Aβ1-42 dichotomy, substantially expanded by multiple post-translational modifications that increase the...

    Authors: Agueda Rostagno, Erwin Cabrera, Tammaryn Lashley and Jorge Ghiso
    Citation: Translational Neurodegeneration 2022 11:30
  7. Authors: Federico Rodriguez-Porcel, Kathryn A. Wyman-Chick, Carla Abdelnour Ruiz, Jon B. Toledo, Daniel Ferreira, Prabitha Urwyler, Rimona S. Weil, Joseph Kane, Andrea Pilotto, Arvid Rongve, Bradley Boeve, John-Paul Taylor, Ian McKeith, Dag Aarsland and Simon J. G. Lewis
    Citation: Translational Neurodegeneration 2022 11:29

    The original article was published in Translational Neurodegeneration 2022 11:24

  8. Neurodegenerative diseases are a heterogeneous group of maladies, characterized by progressive loss of neurons. These diseases involve an intricate pattern of cross-talk between different types of cells to mai...

    Authors: Neelam Younas, Leticia Camila Fernandez Flores, Franziska Hopfner, Günter U. Höglinger and Inga Zerr
    Citation: Translational Neurodegeneration 2022 11:28
  9. Intracellular accumulation of the microtubule-associated protein tau and its hyperphosphorylated forms is a key neuropathological feature of Alzheimer’s disease (AD). Melatonin has been shown to prevent tau hy...

    Authors: Dongmei Chen, Guihua Lan, Ruomeng Li, Yingxue Mei, Xindong Shui, Xi Gu, Long Wang, Tao Zhang, Chen-Ling Gan, Yongfang Xia, Li Hu, Yuan Tian, Mi Zhang and Tae Ho Lee
    Citation: Translational Neurodegeneration 2022 11:27
  10. Patient-to-patient variability in the degree to which β-amyloid, tau and neurodegeneration impact cognitive decline in Alzheimer’s disease (AD) complicates disease modeling and treatment. However, the underlyi...

    Authors: Christopher Daniel Morrone, Aaron Yenhsin Lai, Jossana Bishay, Mary Elizabeth Hill and JoAnne McLaurin
    Citation: Translational Neurodegeneration 2022 11:26
  11. The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, ass...

    Authors: Federico Rodriguez-Porcel, Kathryn A. Wyman-Chick, Carla Abdelnour Ruiz, Jon B. Toledo, Daniel Ferreira, Prabitha Urwyler, Rimona S. Weil, Joseph Kane, Andrea Pilotto, Arvid Rongve, Bradley Boeve, John-Paul Taylor, Ian McKeith, Dag Aarsland and Simon J. G. Lewis
    Citation: Translational Neurodegeneration 2022 11:24

    The Correction to this article has been published in Translational Neurodegeneration 2022 11:29

  12. There has been a growing appreciation for freezing of gait as a disabling symptom that causes a significant burden in Parkinson’s disease. Previous research has highlighted some of the key components that unde...

    Authors: Simon Lewis, Stewart Factor, Nir Giladi, Alice Nieuwboer, John Nutt and Mark Hallett
    Citation: Translational Neurodegeneration 2022 11:23
  13. Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most common type of neurodegenerative dementia. The prevalence of AD is expected to increase as the population ages, placing...

    Authors: Timofey O. Klyucherev, Pawel Olszewski, Alena A. Shalimova, Vladimir N. Chubarev, Vadim V. Tarasov, Misty M. Attwood, Stina Syvänen and Helgi B. Schiöth
    Citation: Translational Neurodegeneration 2022 11:25
  14. Transcriptomic and proteomic profiling of human brain tissue is hindered by the availability of fresh samples from living patients. Postmortem samples usually represent the advanced disease stage of the patien...

    Authors: Salla M. Kangas, Jaakko Teppo, Maija J. Lahtinen, Anu Suoranta, Bishwa Ghimire, Pirkko Mattila, Johanna Uusimaa, Markku Varjosalo, Jani Katisko and Reetta Hinttala
    Citation: Translational Neurodegeneration 2022 11:22
  15. A growing amount of evidence has indicated contributions of variants in causative genes of Parkinson’s disease (PD) to the development of sleep disturbance in PD and prodromal PD stages. In this article, we ai...

    Authors: Jingxuan Huang, Yangfan Cheng, Chunyu Li and Huifang Shang
    Citation: Translational Neurodegeneration 2022 11:21
  16. Alpha-synuclein (α-syn) exhibits pathological misfolding in many human neurodegenerative disorders. We previously showed that α-syn is arginylated in the mouse brain and that lack of arginylation leads to neur...

    Authors: Jun Zhao, Buyan Pan, Marie Fina, Yun Huang, Marie Shimogawa, Kelvin C. Luk, Elizabeth Rhoades, E. James Petersson, Dawei W. Dong and Anna Kashina
    Citation: Translational Neurodegeneration 2022 11:20
  17. Many neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are characterised by the accumulation of misfolded protein deposits in the brain, leading to a progressive destabilisatio...

    Authors: Douglas M. Lopes, Sophie K. Llewellyn and Ian F. Harrison
    Citation: Translational Neurodegeneration 2022 11:19
  18. Alzheimer’s disease (AD) is the most common neurodegenerative disease in the elderly worldwide. However, the complexity of AD pathogenesis leads to discrepancies in the understanding of this disease, and may b...

    Authors: Chenghuan Song, Jiyun Shi, Pingao Zhang, Yongfang Zhang, Jianrong Xu, Lanxue Zhao, Rui Zhang, Hao Wang and Hongzhuan Chen
    Citation: Translational Neurodegeneration 2022 11:18
  19. Multiple lines of evidence suggest possible impairment of the glymphatic system in amyotrophic lateral sclerosis (ALS). To investigate this, we used in vivo magnetic resonance imaging (MRI) to assess glymphati...

    Authors: Akram Zamani, Adam K. Walker, Ben Rollo, Katie L. Ayers, Raysha Farah, Terence J. O’Brien and David K. Wright
    Citation: Translational Neurodegeneration 2022 11:17
  20. Amyotrophic lateral sclerosis (ALS) is characterized by a progressive loss of motor neurons (MNs), leading to paralysis, respiratory failure and death within 2–5 years of diagnosis. The exact mechanisms of spo...

    Authors: Daehwan Kim, Subin Kim, Ashley Sung, Neetika Patel, Nathan Wong, Michael J. Conboy and Irina M. Conboy
    Citation: Translational Neurodegeneration 2022 11:16
  21. Parkinson’s disease (PD) is characterized by intra-neuronal deposition of the protein α-synuclein (α-syn) and by deficiencies of the catecholamines dopamine and norepinephrine (NE) in the brain and heart. Accu...

    Authors: Risa Isonaka, Patti Sullivan and David S. Goldstein
    Citation: Translational Neurodegeneration 2022 11:15
  22. Growing evidence suggests an association between Parkinson’s disease (PD) and diabetes mellitus (DM). At the cellular level, long-term elevated levels of glucose have been shown to lead to nigrostriatal degene...

    Authors: Yi-Qing Lv, Lin Yuan, Yan Sun, Hao-Wen Dou, Ji-Hui Su, Zhi-Pan Hou, Jia-Yi Li and Wen Li
    Citation: Translational Neurodegeneration 2022 11:14
  23. Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B (encoding a copper-transporting P-type ATPase) variants that shows various characteristics according to race and geogr...

    Authors: Shijie Zhang, Wenming Yang, Xiang Li, Pei Pei, Ting Dong, Yue Yang and Jing Zhang
    Citation: Translational Neurodegeneration 2022 11:13
  24. The ultimate goal in Parkinson's disease (PD) research remains the identification of treatments that are capable of slowing or even halting the progression of the disease. The failure of numerous past disease-...

    Authors: Philipp Mahlknecht, Kathrin Marini, Mario Werkmann, Werner Poewe and Klaus Seppi
    Citation: Translational Neurodegeneration 2022 11:11
  25. Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are one of the most frequent genetic causes of both familial and sporadic Parkinson’s disease (PD). Mounting evidence has demonstrated pathological simil...

    Authors: Eunice Eun Seo Chang, Philip Wing-Lok Ho, Hui-Fang Liu, Shirley Yin-Yu Pang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, David Boyer Ramsden and Shu-Leong Ho
    Citation: Translational Neurodegeneration 2022 11:10
  26. Accumulating α-synuclein (α-syn) aggregates in neurons and glial cells are the staples of many synucleinopathy disorders, such as Parkinson’s disease (PD). Since brain adenosine becomes greatly elevated in age...

    Authors: Elisabet Jakova, Mohamed Taha Moutaoufik, Jeremy S. Lee, Mohan Babu and Francisco S. Cayabyab
    Citation: Translational Neurodegeneration 2022 11:9
  27. Although growing evidence links beta-amyloid (Aβ) and neuronal hyperexcitability in preclinical mouse models of Alzheimer’s disease (AD), a similar association in humans is yet to be established. The first aim...

    Authors: Hannes Devos, Kathleen Gustafson, Ke Liao, Pedram Ahmadnezhad, Bradley Estes, Laura E. Martin, Jonathan D. Mahnken, William M. Brooks and Jeffrey M. Burns
    Citation: Translational Neurodegeneration 2022 11:8
  28. Multiple system atrophy (MSA) is a neurodegenerative condition characterized by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and pyramidal features. Although the distribution of ...

    Authors: Ivan Martinez-Valbuena, Naomi P. Visanji, Ain Kim, Heather H. C. Lau, Raphaella W. L. So, Sohaila Alshimemeri, Andrew Gao, Michael A. Seidman, Maria R. Luquin, Joel C. Watts, Anthony E. Lang and Gabor G. Kovacs
    Citation: Translational Neurodegeneration 2022 11:7
  29. Tai Chi has been shown to improve motor symptoms in Parkinson’s disease (PD), but its long-term effects and the related mechanisms remain to be elucidated. In this study, we investigated the effects of long-te...

    Authors: Gen Li, Pei Huang, Shi-Shuang Cui, Yu-Yan Tan, Ya-Chao He, Xin Shen, Qin-Ying Jiang, Ping Huang, Gui-Ying He, Bin-Yin Li, Yu-Xin Li, Jin Xu, Zheng Wang and Sheng-Di Chen
    Citation: Translational Neurodegeneration 2022 11:6
  30. Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (A...

    Authors: Shirley Yin-Yu Pang, Rachel Cheuk Nam Lo, Philip Wing-Lok Ho, Hui-Fang Liu, Eunice Eun Seo Chang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, Wing Yan Wong, Michelle Hiu-Wai Kung, David Boyer Ramsden and Shu-Leong Ho
    Citation: Translational Neurodegeneration 2022 11:5
  31. The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzhe...

    Authors: Alessandro Dario Confettura, Eleonora Cuboni, Mohamed Rafeet Ammar, Shaobo Jia, Guilherme M. Gomes, PingAn Yuanxiang, Rajeev Raman, Tingting Li, Katarzyna M. Grochowska, Robert Ahrends, Anna Karpova, Alexander Dityatev and Michael R. Kreutz
    Citation: Translational Neurodegeneration 2022 11:2
  32. Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative diseases. Studies of glial fibrillary acidic protein (GFAP), an astrocytic damage marker, may he...

    Authors: Nuole Zhu, Miguel Santos-Santos, Ignacio Illán-Gala, Victor Montal, Teresa Estellés, Isabel Barroeta, Miren Altuna, Javier Arranz, Laia Muñoz, Olivia Belbin, Isabel Sala, Maria Belén Sánchez-Saudinós, Andrea Subirana, Laura Videla, Jordi Pegueroles, Rafael Blesa…
    Citation: Translational Neurodegeneration 2021 10:50
  33. Alzheimer’s disease (AD) is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive decline. Failures in the development of therapeutics targeting amyloid-β (Aβ...

    Authors: Hyeon soo Kim, Sujin Kim, Soo Jung Shin, Yong Ho Park, Yunkwon Nam, Chae won Kim, Kang won Lee, Sung-Min Kim, In Duk Jung, Hyun Duk Yang, Yeong-Min Park and Minho Moon
    Citation: Translational Neurodegeneration 2021 10:49
  34. Alzheimer’s disease (AD) is the most common cause of dementia, and is characterized by amyloid-β (Aβ) plaques and tauopathy. Reducing Aβ has been considered a major AD treatment strategy in pharmacological and...

    Authors: Mincheol Park, Gia Minh Hoang, Thien Nguyen, Eunkyung Lee, Hyun Jin Jung, Youngshik Choe, Moon Hwan Lee, Jae Youn Hwang, Jae Gwan Kim and Tae Kim
    Citation: Translational Neurodegeneration 2021 10:48
  35. Parkinson’s disease (PD) is an incurable, devastating disorder that is characterized by pathological protein aggregation and neurodegeneration in the substantia nigra. In recent years, growing evidence has imp...

    Authors: Anastazja M. Gorecki, Chidozie C. Anyaegbu and Ryan S. Anderton
    Citation: Translational Neurodegeneration 2021 10:47
  36. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective, early degeneration of motor neurons in the brain and spinal cord. Motor neurons have long axonal proje...

    Authors: Frances Theunissen, Phillip K. West, Samuel Brennan, Bojan Petrović, Kosar Hooshmand, P. Anthony Akkari, Matt Keon and Boris Guennewig
    Citation: Translational Neurodegeneration 2021 10:46
  37. Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, accompanied by amyloid-β (Aβ) overload and hyperphosphorylated tau accumulation in the brain. Synaptic dy...

    Authors: Moxin Wu, Manqing Zhang, Xiaoping Yin, Kai Chen, Zhijian Hu, Qin Zhou, Xianming Cao, Zhiying Chen and Dan Liu
    Citation: Translational Neurodegeneration 2021 10:45
  38. Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening has shown efficacy in removal of amyloid plaque and improvement of cognitive functions in preclinical studies, but this is rarely reported in...

    Authors: So Hee Park, Kyoungwon Baik, Seun Jeon, Won Seok Chang, Byoung Seok Ye and Jin Woo Chang
    Citation: Translational Neurodegeneration 2021 10:44
  39. The dopaminergic nigrostriatal neurons (DA cells) in healthy people present a slow degeneration with aging, which produces cellular debris throughout life. About 2%–5% of people present rapid cell degeneration...

    Authors: Ingrid Morales, Ricardo Puertas-Avendaño, Alberto Sanchez, Adrian Perez-Barreto, Clara Rodriguez-Sabate and Manuel Rodriguez
    Citation: Translational Neurodegeneration 2021 10:43
  40. Although many causative genes have been uncovered in recent years, genetic diagnosis is still missing for approximately 50% of autosomal recessive cerebellar ataxia (ARCA) patients. Few studies have been perfo...

    Authors: Hao-Ling Cheng, Ya-Ru Shao, Yi Dong, Hai-Lin Dong, Lu Yang, Yin Ma, Ying Shen and Zhi-Ying Wu
    Citation: Translational Neurodegeneration 2021 10:40
  41. Parkinson’s disease (PD) is a common neurodegenerative disorder that primarily affects the elderly. While the etiology of PD is likely multifactorial with the involvement of genetic, environmental, aging and o...

    Authors: Changjing Wang, Tongtong Yang, Meiyu Liang, Junxia Xie and Ning Song
    Citation: Translational Neurodegeneration 2021 10:39
  42. Amyloid-β (Aβ) immunotherapy is a promising therapeutic strategy in the fight against Alzheimer’s disease (AD). A number of monoclonal antibodies have entered clinical trials for AD. Some of them have failed d...

    Authors: Fadi Rofo, Jos Buijs, Ronny Falk, Ken Honek, Lars Lannfelt, Anna M. Lilja, Nicole G. Metzendorf, Tobias Gustavsson, Dag Sehlin, Linda Söderberg and Greta Hultqvist
    Citation: Translational Neurodegeneration 2021 10:38
  43. New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promisi...

    Authors: Neus Barranco, Virginia Plá, Daniel Alcolea, Irene Sánchez-Domínguez, Reiner Fischer-Colbrie, Isidro Ferrer, Alberto Lleó and Fernando Aguado
    Citation: Translational Neurodegeneration 2021 10:37

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