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Translational Neurodegeneration

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  1. Content type: Research

    PINK1 (PTEN-induced putative kinase 1) gene is the causal gene for recessive familial type 6 of Parkinson’s disease (PARK6), which is an early-onset autosomal recessive inherited neurodegenerative disease. PIN...

    Authors: Ji-feng Guo, Ling-yan Yao, Qi-ying Sun, Yi-ting Cui, Yang Yang, Qian Xu, Xin-xiang Yan and Bei-sha Tang

    Citation: Translational Neurodegeneration 2017 6:34

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  2. Content type: Review

    Huntington’s Disease (HD) is a genetically dominant trinucleotide repeat disorder resulting from CAG repeats within the Huntingtin (HTT) gene exceeding a normal range (> 36 CAGs). Symptoms of the disease manif...

    Authors: Sebastian Aguiar, Bram van der Gaag and Francesco Albert Bosco Cortese

    Citation: Translational Neurodegeneration 2017 6:30

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  3. Content type: Research

    Tau vaccination and administration of anti-tau antibodies can prevent pathology and cognitive impairment in transgenic mouse models of tauopathy, suggesting that therapies which increase anti-tau antibodies mi...

    Authors: Andrea C. Klaver, Mary P. Coffey, David A. Bennett and David A. Loeffler

    Citation: Translational Neurodegeneration 2017 6:32

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  4. Content type: Research

    Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron disorders. Effective therapeutic strategies are an unmet need for these disorders....

    Authors: Rafael Lazo-Gomez and Ricardo Tapia

    Citation: Translational Neurodegeneration 2017 6:31

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  5. Content type: Research

    Extensive loss of donor neural stem cell (NSCs) due to ischemic stress and low rate of differentiation at the site of cell graft are two of the major issues that hamper optimal outcome in NSCs transplantation ...

    Authors: Parisa Tabeshmehr, Haider Kh Husnain, Mahin Salmannejad, Mahsa Sani, Seyed Mojtaba Hosseini and Mohammad Hossein Khorraminejad Shirazi

    Citation: Translational Neurodegeneration 2017 6:29

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  6. Content type: Review

    Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkins...

    Authors: Panchanan Maiti, Jayeeta Manna and Gary L. Dunbar

    Citation: Translational Neurodegeneration 2017 6:28

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  7. Content type: Review

    The clinical diagnosis of neurodegenerative disorders based on phenotype is difficult in heterogeneous conditions with overlapping symptoms. It does not take into account the disease etiology or the highly var...

    Authors: Shirley Yin-Yu Pang, Kay-Cheong Teo, Jacob Shujui Hsu, Richard Shek-Kwan Chang, Miaoxin Li, Pak-Chung Sham and Shu-Leong Ho

    Citation: Translational Neurodegeneration 2017 6:27

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  8. Content type: Review

    Photophobia is a common symptom seen in many neurologic disorders, however, its pathophysiology remains unclear. Even the term is ambiguous. In this paper, we review the epidemiology and clinical manifestation...

    Authors: Yiwen Wu and Mark Hallett

    Citation: Translational Neurodegeneration 2017 6:26

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  9. Content type: Review

    Alzheimer’s disease (AD) is the most common age-dependent disease of dementia, and there is currently no cure available. This hallmark pathologies of AD are the presence of amyloid plaques and neurofibrillary ...

    Authors: Brati Das and Riqiang Yan

    Citation: Translational Neurodegeneration 2017 6:23

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  10. Content type: Review

    Traumatic brain injury is among the most common causes of death and disability in youth and young adults. In addition to the acute risk of morbidity with moderate to severe injuries, traumatic brain injury is ...

    Authors: Marcela Cruz-Haces, Jonathan Tang, Glen Acosta, Joseph Fernandez and Riyi Shi

    Citation: Translational Neurodegeneration 2017 6:20

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  11. Content type: Review

    Alzheimer’s disease (AD) is a chronic neurodegenerative disease, which is associated with learning and memory impairment in the elderly. Recent studies have found that treating AD in the way of chromatin remod...

    Authors: Shuang-shuang Yang, Rui Zhang, Gang Wang and Yong-fang Zhang

    Citation: Translational Neurodegeneration 2017 6:19

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  12. Content type: Research

    There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease (PD-MCI) and the coping strategies used by these caregivers.

    Authors: Ann J. Jones, Roeline G. Kuijer, Leslie Livingston, Daniel Myall, Kyla Horne, Michael MacAskill, Toni Pitcher, Paul T. Barrett, Tim J. Anderson and John C. Dalrymple-Alford

    Citation: Translational Neurodegeneration 2017 6:17

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  13. Content type: Review

    Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. Since distinct diseases can cause similar tremor manifestations and vice-versa, it is...

    Authors: Wei Chen, Franziska Hopfner, Jos Steffen Becktepe and Günther Deuschl

    Citation: Translational Neurodegeneration 2017 6:16

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  14. Content type: Research

    Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for Parkinson’s disease (PD), the predictive effect of levodopa responsiveness on surgical outcomes was confirmed by some studies,...

    Authors: Xin-Ling Su, Xiao-Guang Luo, Hong Lv, Jun Wang, Yan Ren and Zhi-Yi He

    Citation: Translational Neurodegeneration 2017 6:14

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  15. Content type: Research

    Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a new candidate growth factor for dopaminergic neurons against endoplasmic reticulum stress (ER stress). HSP70 family, a chaperon like heat shock p...

    Authors: Hui Sun, Ming Jiang, Xing Fu, Qiong Cai, Jingxing Zhang, Yanxin Yin, Jia Guo, Lihua Yu, Yun Jiang, Yigang Liu, Liang Feng, Zhiyu Nie, Jianmin Fang and Lingjing Jin

    Citation: Translational Neurodegeneration 2017 6:12

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  16. Content type: Review

    Some studies have shown that low frequency stimulation (LFS, most commonly 60 Hz), compared to high frequency stimulation (HFS, most commonly 130 Hz), has beneficial effects, short-term or even long-term, on i...

    Authors: Tao Xie, Mahesh Padmanaban, Lisa Bloom, Ellen MacCracken, Breanna Bertacchi, Abraham Dachman and Peter Warnke

    Citation: Translational Neurodegeneration 2017 6:13

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  17. Content type: Research

    Recent studies have found that the functional catechol-O-methyltransferase (COMT) gene may be associated with the susceptibility to and pharmacotherapy of Parkinson’s disease (PD). In this case–control study, ...

    Authors: Yiwei Qian, Jiujiang Liu, Shaoqing Xu, Xiaodong Yang and Qin Xiao

    Citation: Translational Neurodegeneration 2017 6:11

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  18. Content type: Research

    Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis, which converts glutamine into glutamate. Glutamate is the major neurotransmitter of excitatory synapses,...

    Authors: Yuju Li, Justin Peer, Runze Zhao, Yinghua Xu, Beiqing Wu, Yi Wang, Changhai Tian, Yunlong Huang and Jialin Zheng

    Citation: Translational Neurodegeneration 2017 6:10

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