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  1. Therapeutic approaches aimed at lowering toxic mutant huntingtin (mHTT) levels in the brain can reverse disease phenotypes in animal models of Huntington's disease (HD) and are currently being evaluated in cli...

    Authors: Nicholas S. Caron, Lauren M. Byrne, Fanny L. Lemarié, Jeffrey N. Bone, Amirah E.-E. Aly, Seunghyun Ko, Christine Anderson, Lorenzo L. Casal, Austin M. Hill, David J. Hawellek, Peter McColgan, Edward J. Wild, Blair R. Leavitt and Michael R. Hayden
    Citation: Translational Neurodegeneration 2024 13:50
  2. Parkinson’s disease (PD) is the second most common neurodegenerative disease. The development of PD is closely linked to genetic and environmental factors, with GBA1 variants being the most common genetic risk. M...

    Authors: Xuxiang Zhang, Heng Wu, Beisha Tang and Jifeng Guo
    Citation: Translational Neurodegeneration 2024 13:48
  3. Neurodegenerative disorders are typically “split” based on their hallmark clinical, anatomical, and pathological features, but they can also be “lumped” by a shared feature of impaired mitochondrial biology. T...

    Authors: Matthew C. L. Phillips and Martin Picard
    Citation: Translational Neurodegeneration 2024 13:46
  4. The diagnosis of neurodegenerative diseases (NDDs) remains challenging, and existing therapeutic approaches demonstrate little efficacy. NDD drug delivery can be achieved through the utilization of nanostructu...

    Authors: Chao Gao, Ran Xiong, Zhi-yu Zhang, Hua Peng, Yuan-kai Gu, Wei Xu, Wei-ting Yang, Yan Liu, Jie Gao and You Yin
    Citation: Translational Neurodegeneration 2024 13:43
  5. Alzheimer’s disease (AD) is a progressive neurological disorder that primarily impacts cognitive function. Currently there are no disease-modifying treatments to stop or slow its progression. Recent studies ha...

    Authors: Ni Liu, Anaer Haziyihan, Wei Zhao, Yu Chen and Hongbo Chao
    Citation: Translational Neurodegeneration 2024 13:42
  6. The rising prevalence of diabetes mellitus has casted a spotlight on one of its significant sequelae: cognitive impairment. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally developed for diabetes ...

    Authors: Jiaqi Mei, Yi Li, Liyan Niu, Ruikai Liang, Mingyue Tang, Qi Cai, Jingdong Xu, Deju Zhang, Xiaoping Yin, Xiao Liu, Yunfeng Shen, Jianping Liu, Minxuan Xu, Panpan Xia, Jitao Ling, Yuting Wu…
    Citation: Translational Neurodegeneration 2024 13:41
  7. The deposition of abnormal tau protein is characteristic of Alzheimer’s disease (AD) and a class of neurodegenerative diseases called tauopathies. Physiologically, tau maintains an intrinsically disordered str...

    Authors: Xingyu Zhang, Jiangyu Wang, Zhentao Zhang and Keqiang Ye
    Citation: Translational Neurodegeneration 2024 13:40
  8. Deoxyribonuclease 2 (DNase II) plays a key role in clearing cytoplasmic double-stranded DNA (dsDNA). Deficiency of DNase II leads to DNA accumulation in the cytoplasm. Persistent dsDNA in neurons is an early p...

    Authors: Ling-Jie Li, Xiao-Ying Sun, Ya-Ru Huang, Shuai Lu, Yu-Ming Xu, Jing Yang, Xi-Xiu Xie, Jie Zhu, Xiao-Yun Niu, Dan Wang, Shi-Yu Liang, Xiao-Yu Du, Sheng-Jie Hou, Xiao-Lin Yu and Rui-Tian Liu
    Citation: Translational Neurodegeneration 2024 13:39
  9. There is increasing evidence for blood–brain barrier (BBB) alterations in Parkinson’s disease (PD), the second most common neurodegenerative disorder with rapidly rising prevalence. Altered tight junction and ...

    Authors: Kristina Lau, Rebecca Kotzur and Franziska Richter
    Citation: Translational Neurodegeneration 2024 13:37
  10. Seed amplification assays (SAA) enable the amplification of pathological misfolded proteins, including α-synuclein (αSyn), in both tissue homogenates and body fluids of Parkinson’s disease (PD) patients. SAA i...

    Authors: Hengxu Mao, Yaoyun Kuang, Du Feng, Xiang Chen, Lin Lu, Wencheng Xia, Tingting Gan, Weimeng Huang, Wenyuan Guo, Hancun Yi, Yirong Yang, Zhuohua Wu, Wei Dai, Hui Sun, Jieyuan Wu, Rui Zhang…
    Citation: Translational Neurodegeneration 2024 13:35
  11. Depressive symptoms often occur in patients with Alzheimer's disease (AD) and exacerbate the pathogenesis of AD. However, the neural circuit mechanisms underlying the AD-associated depression remain unclear. T...

    Authors: Meiqin Chen, Chenlu Wang, Yinan Lin, Yanbing Chen, Wenting Xie, Xiaoting Huang, Fan Zhang, Congrui Fu, Kai Zhuang, Tingting Zou, Dan Can, Huifang Li, Shengxi Wu, Ceng Luo and Jie Zhang
    Citation: Translational Neurodegeneration 2024 13:34
  12. The last decades have witnessed huge efforts devoted to deciphering the pathological mechanisms underlying Alzheimer’s Disease (AD) and to testing new drugs, with the recent FDA approval of two anti-amyloid mo...

    Authors: Maria Luisa De Paolis, Ilaria Paoletti, Claudio Zaccone, Fioravante Capone, Marcello D’Amelio and Paraskevi Krashia
    Citation: Translational Neurodegeneration 2024 13:33
  13. The central nervous system (CNS) is integrated by glial and neuronal cells, and both release extracellular vesicles (EVs) that participate in CNS homeostasis. EVs could be one of the best candidates to operate...

    Authors: Rocío del Carmen Bravo-Miana, Jone Karmele Arizaga-Echebarria and David Otaegui
    Citation: Translational Neurodegeneration 2024 13:32
  14. TDP-43 proteinopathies are a heterogeneous group of neurodegenerative disorders that share the presence of aberrant, misfolded and mislocalized deposits of the protein TDP-43, as in the case of amyotrophic lat...

    Authors: Juan I. López-Carbonero, Irene García-Toledo, Laura Fernández-Hernández, Pablo Bascuñana, María J. Gil-Moreno, Jordi A. Matías-Guiu and Silvia Corrochano
    Citation: Translational Neurodegeneration 2024 13:29
  15. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motor neurons, resulting in global health burden and limited post-diagnosis life expectancy. Althou...

    Authors: Miaodan Huang, Yong U. Liu, Xiaoli Yao, Dajiang Qin and Huanxing Su
    Citation: Translational Neurodegeneration 2024 13:28
  16. Authors: Yi-Ting Wang, Nicholas J. Ashton, Stijn Servaes, Johanna Nilsson, Marcel S. Woo, Tharick A. Pascoal, Cécile Tissot, Nesrine Rahmouni, Joseph Therriault, Firoza Lussier, Mira Chamoun, Serge Gauthier, Ann Brinkmalm, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto…
    Citation: Translational Neurodegeneration 2024 13:27
  17. The use of biomarker-led clinical trial designs has been transformative for investigating amyloid-targeting therapies for Alzheimer’s disease (AD). The designs have ensured the correct selection of patients on...

    Authors: Lewis K. Penny, Richard Lofthouse, Mohammad Arastoo, Andy Porter, Soumya Palliyil, Charles R. Harrington and Claude M. Wischik
    Citation: Translational Neurodegeneration 2024 13:25
  18. Adult neurogenesis occurs in the subventricular zone (SVZ) and the subgranular zone of the dentate gyrus in the hippocampus. The neuronal stem cells in these two neurogenic niches respond differently to variou...

    Authors: Dongfang Jiang, Hongmei Liu, Tingting Li, Song Zhao, Keyan Yang, Fuwen Yao, Bo Zhou, Haiping Feng, Sijia Wang, Jiaqi Shen, Jinglan Tang, Yu-Xin Zhang, Yun Wang, Caixia Guo and Tie-Shan Tang
    Citation: Translational Neurodegeneration 2024 13:24
  19. Mitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome. They are closely related to the physiology and pathology of ...

    Authors: Nanshan Song, Shuyuan Mei, Xiangxu Wang, Gang Hu and Ming Lu
    Citation: Translational Neurodegeneration 2024 13:23
  20. The renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues and organs, including the brain, have a local paracrine RAS...

    Authors: Jose Luis Labandeira-Garcia, Carmen M. Labandeira, Maria J. Guerra and Ana I. Rodriguez-Perez
    Citation: Translational Neurodegeneration 2024 13:22
  21. Huntington's disease (HD) is a devastating neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein, resulting from a CAG repeat expansion in the huntingtin gene HTT. HD is charact...

    Authors: Russell G. Wells, Lee E. Neilson, Andrew W. McHill and Amie L. Hiller
    Citation: Translational Neurodegeneration 2024 13:17
  22. Authors: Alessandra Bigi, Giulia Fani, Valentina Bessi, Liliana Napolitano, Silvia Bagnoli, Assunta Ingannato, Lorenzo Neri, Roberta Cascella, Paolo Matteini, Sandro Sorbi, Benedetta Nacmias, Cristina Cecchi and Fabrizio Chiti
    Citation: Translational Neurodegeneration 2024 13:14
  23. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate the LRRK2 kinase activity, making LRRK2 kinase inhibitors an attractive th...

    Authors: Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard L. Li, Cheryl E. G. Leyns, Lakshmi Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M. Y. Lee, Dani S. Bassett and Michael X. Henderson
    Citation: Translational Neurodegeneration 2024 13:13
  24. The aetiologies and origins of neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD), are complex and multifa...

    Authors: Yuan-Yuan Ma, Xin Li, Jin-Tai Yu and Yan-Jiang Wang
    Citation: Translational Neurodegeneration 2024 13:12
  25. It is now realized that Parkinson’s disease (PD) pathology extends beyond the substantia nigra, affecting both central and peripheral nervous systems, and exhibits a variety of non-motor symptoms often precedi...

    Authors: Emmanouela Leandrou, Ioanna Chalatsa, Dimitrios Anagnostou, Christina Machalia, Maria Semitekolou, Vicky Filippa, Manousos Makridakis, Antonia Vlahou, Ema Anastasiadou, Kostas Vekrellis and Evangelia Emmanouilidou
    Citation: Translational Neurodegeneration 2024 13:11
  26. Degeneration of the locus coeruleus (LC) noradrenergic system contributes to clinical symptoms in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Diffusion magnetic resonance imaging (MRI) has the poten...

    Authors: Chen-Pei Lin, Irene Frigerio, John G. J. M. Bol, Maud M. A. Bouwman, Alex J. Wesseling, Martin J. Dahl, Annemieke J. M. Rozemuller, Ysbrand D. van der Werf, Petra J. W. Pouwels, Wilma D. J. van de Berg and Laura E. Jonkman
    Citation: Translational Neurodegeneration 2024 13:9
  27. Little is known about the impact of the COVID-19 pandemic on patients with Parkinson’s disease (PD) at different stages of the pandemic. This study aims to assess the lives and disease status of PD patients du...

    Authors: Pei Huang, Yu-Yan Tan, Biao Chen, Hui-Fang Shang, Li-Juan Wang, Chun-Feng Liu, Ling Chen, Ying Chang, Han Wang, Xue-Lian Wang, Xiao-Guang Lei, Li-Fen Yao, Yang Yu, Zheng Ye, Hai-Bo Chen and Sheng-Di Chen
    Citation: Translational Neurodegeneration 2024 13:8
  28. Ageing is a crucial risk factor for Alzheimer’s disease (AD) and is characterised by systemic changes in both intracellular and extracellular microenvironments that affect the entire body instead of a single o...

    Authors: Yuqing Liu, Yejun Tan, Zheyu Zhang, Min Yi, Lemei Zhu and Weijun Peng
    Citation: Translational Neurodegeneration 2024 13:7
  29. Neurodegenerative disorders present complex pathologies characterized by various interconnected factors, including the aggregation of misfolded proteins, oxidative stress, neuroinflammation and compromised blo...

    Authors: Arazu Sharif, John Mamo, Virginie Lam, Hani Al-Salami, Armin Mooranian, Gerald F. Watts, Roger Clarnette, Giuseppe Luna and Ryu Takechi
    Citation: Translational Neurodegeneration 2024 13:6
  30. Microglia-mediated neuroinflammation in Alzheimer’s disease (AD) is not only a response to pathophysiological events, but also plays a causative role in neurodegeneration. Cytoplasmic cysteinyl-tRNA synthetase...

    Authors: Xiu-Hong Qi, Peng Chen, Yue-Ju Wang, Zhe-Ping Zhou, Xue-Chun Liu, Hui Fang, Chen-Wei Wang, Ji Liu, Rong-Yu Liu, Han-Kui Liu, Zhen-Xin Zhang and Jiang-Ning Zhou
    Citation: Translational Neurodegeneration 2024 13:3
  31. Alzheimer's disease (AD) is considered to have a multifactorial etiology. The hallmark of AD is progressive neurodegeneration, which is characterized by the deepening loss of memory and a high mortality rate i...

    Authors: Hoda M. Gebril, Aravind Aryasomayajula, Mariana Reis Nogueira de Lima, Kathryn E. Uhrich and Prabhas V. Moghe
    Citation: Translational Neurodegeneration 2024 13:2

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    Journal Impact Factor: 10.8
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    Source Normalized Impact per Paper (SNIP): 2.374
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