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Translational Neurodegeneration


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  1. Content type: Short report

    Tauopathies comprise a family of neurodegenerative disorders including Alzheimer’s disease for which there is an urgent and unmet need for disease-modifying treatments. Tauopathies are characterized by patholo...

    Authors: Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J. Weiss, Yitzhak Tor, Jeffrey D. Esko and Nadia Soussi-Yanicostas

    Citation: Translational Neurodegeneration 2018 7:6

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  2. Content type: Review

    Nearly 30% of adults 40 years and older in the United States are on a statin. Their widespread use heightens the importance of careful consideration of their varied effects on the body. Although randomized con...

    Authors: Bob G. Schultz, Denise K. Patten and Daniel J. Berlau

    Citation: Translational Neurodegeneration 2018 7:5

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  3. Content type: Review

    Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly est...

    Authors: Belal Shohayeb, Mohamed Diab, Mazen Ahmed and Dominic Chi Hiung Ng

    Citation: Translational Neurodegeneration 2018 7:4

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  4. Content type: Review

    Hydrogen Sulfide (H2S) and Nitric Oxide (NO) have become recognized as important gaseous signaling molecules with enormous pharmacological effects, therapeutic value, and central physiological roles. NO is one of...

    Authors: Sandesh Panthi, Sumeet Manandhar and Kripa Gautam

    Citation: Translational Neurodegeneration 2018 7:3

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  5. Content type: Review

    Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extr...

    Authors: Xiaoguang Du, Xinyi Wang and Meiyu Geng

    Citation: Translational Neurodegeneration 2018 7:2

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  6. Content type: Research

    Rapid eye movement sleep behavior disorder (RBD) and Parkinson’s disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. This study aims to confi...

    Authors: Ye Liu, Xiao-Ying Zhu, Xiao-Jin Zhang, Sheng-Han Kuo, William G. Ondo and Yun-Cheng Wu

    Citation: Translational Neurodegeneration 2017 6:35

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  7. Content type: Review

    In this mini-review, we summarize recent findings relating to the prion-like propagation of α-synuclein (α-syn) and the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s dise...

    Authors: Daniel Kam Yin Chan, Ying Hua Xu, Luke Kar Man Chan, Nady Braidy and George D. Mellick

    Citation: Translational Neurodegeneration 2017 6:33

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  8. Content type: Research

    PINK1 (PTEN-induced putative kinase 1) gene is the causal gene for recessive familial type 6 of Parkinson’s disease (PARK6), which is an early-onset autosomal recessive inherited neurodegenerative disease. PIN...

    Authors: Ji-feng Guo, Ling-yan Yao, Qi-ying Sun, Yi-ting Cui, Yang Yang, Qian Xu, Xin-xiang Yan and Bei-sha Tang

    Citation: Translational Neurodegeneration 2017 6:34

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  9. Content type: Review

    Huntington’s Disease (HD) is a genetically dominant trinucleotide repeat disorder resulting from CAG repeats within the Huntingtin (HTT) gene exceeding a normal range (> 36 CAGs). Symptoms of the disease manif...

    Authors: Sebastian Aguiar, Bram van der Gaag and Francesco Albert Bosco Cortese

    Citation: Translational Neurodegeneration 2017 6:30

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  10. Content type: Research

    Tau vaccination and administration of anti-tau antibodies can prevent pathology and cognitive impairment in transgenic mouse models of tauopathy, suggesting that therapies which increase anti-tau antibodies mi...

    Authors: Andrea C. Klaver, Mary P. Coffey, David A. Bennett and David A. Loeffler

    Citation: Translational Neurodegeneration 2017 6:32

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  11. Content type: Research

    Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron disorders. Effective therapeutic strategies are an unmet need for these disorders....

    Authors: Rafael Lazo-Gomez and Ricardo Tapia

    Citation: Translational Neurodegeneration 2017 6:31

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  12. Content type: Research

    Extensive loss of donor neural stem cell (NSCs) due to ischemic stress and low rate of differentiation at the site of cell graft are two of the major issues that hamper optimal outcome in NSCs transplantation ...

    Authors: Parisa Tabeshmehr, Haider Kh Husnain, Mahin Salmannejad, Mahsa Sani, Seyed Mojtaba Hosseini and Mohammad Hossein Khorraminejad Shirazi

    Citation: Translational Neurodegeneration 2017 6:29

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  13. Content type: Review

    Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkins...

    Authors: Panchanan Maiti, Jayeeta Manna and Gary L. Dunbar

    Citation: Translational Neurodegeneration 2017 6:28

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  14. Content type: Review

    The clinical diagnosis of neurodegenerative disorders based on phenotype is difficult in heterogeneous conditions with overlapping symptoms. It does not take into account the disease etiology or the highly var...

    Authors: Shirley Yin-Yu Pang, Kay-Cheong Teo, Jacob Shujui Hsu, Richard Shek-Kwan Chang, Miaoxin Li, Pak-Chung Sham and Shu-Leong Ho

    Citation: Translational Neurodegeneration 2017 6:27

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  15. Content type: Review

    Photophobia is a common symptom seen in many neurologic disorders, however, its pathophysiology remains unclear. Even the term is ambiguous. In this paper, we review the epidemiology and clinical manifestation...

    Authors: Yiwen Wu and Mark Hallett

    Citation: Translational Neurodegeneration 2017 6:26

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  16. Content type: Review

    Alzheimer’s disease (AD) is the most common age-dependent disease of dementia, and there is currently no cure available. This hallmark pathologies of AD are the presence of amyloid plaques and neurofibrillary ...

    Authors: Brati Das and Riqiang Yan

    Citation: Translational Neurodegeneration 2017 6:23

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  17. Content type: Review

    Traumatic brain injury is among the most common causes of death and disability in youth and young adults. In addition to the acute risk of morbidity with moderate to severe injuries, traumatic brain injury is ...

    Authors: Marcela Cruz-Haces, Jonathan Tang, Glen Acosta, Joseph Fernandez and Riyi Shi

    Citation: Translational Neurodegeneration 2017 6:20

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  18. Content type: Review

    Alzheimer’s disease (AD) is a chronic neurodegenerative disease, which is associated with learning and memory impairment in the elderly. Recent studies have found that treating AD in the way of chromatin remod...

    Authors: Shuang-shuang Yang, Rui Zhang, Gang Wang and Yong-fang Zhang

    Citation: Translational Neurodegeneration 2017 6:19

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  19. Content type: Research

    There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease (PD-MCI) and the coping strategies used by these caregivers.

    Authors: Ann J. Jones, Roeline G. Kuijer, Leslie Livingston, Daniel Myall, Kyla Horne, Michael MacAskill, Toni Pitcher, Paul T. Barrett, Tim J. Anderson and John C. Dalrymple-Alford

    Citation: Translational Neurodegeneration 2017 6:17

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