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  1. Content type: Research

    The use of adjunct rasagiline in levodopa-treated patients with Parkinson’s disease and motor fluctuations is supported by findings from large-scale clinical studies. This study is to investigate the efficacy ...

    Authors: Zhenxin Zhang, Ming Shao, Shengdi Chen, Chunfeng Liu, Rong Peng, Yansheng Li, Jian Wang, Suiqiang Zhu, Qiumin Qu, Xiaoying Zhang, Haibo Chen, Xiangru Sun, Yanping Wang, Shenggang Sun, Baorong Zhang, Jimei Li…

    Citation: Translational Neurodegeneration 2018 7:14

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  2. Content type: Short report

    Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, neuropathologically characterized by misfolded protein aggregation, called Lewy bodies and Lewy neurites. PD is a slow-progressive...

    Authors: Qian-Qian Chen, Caroline Haikal, Wen Li, Ming-Tao Li, Zhan-You Wang and Jia-Yi Li

    Citation: Translational Neurodegeneration 2018 7:13

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  3. Content type: Review

    The NIA-AA research framework proposes a biological definition of Alzheimer’s disease, where asymptomatic persons with amyloid deposition would be considered as having this disease prior to symptoms.

    Authors: S. Gauthier, H. Zhang, K. P. Ng, T.A. Pascoal and P. Rosa-Neto

    Citation: Translational Neurodegeneration 2018 7:12

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  4. Content type: Review

    Deep Brain Stimulation (DBS) therapy for the treatment of Parkinson’s Disease (PD) is now a well-established option for some patients. Postoperative standardized programming processes can improve the level of ...

    Authors: Shengdi Chen, Guodong Gao, Tao Feng and Jianguo Zhang

    Citation: Translational Neurodegeneration 2018 7:11

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  5. Content type: Research

    Brain consists of plenty of complicated cytoarchitecture. Gaussian-model based diffusion tensor imaging (DTI) is far from satisfactory interpretation of the structural complexity. Diffusion kurtosis imaging (D...

    Authors: Jia-Xing Cheng, Hong-Ying Zhang, Zheng-Kun Peng, Yao Xu, Hui Tang, Jing-Tao Wu and Jun Xu

    Citation: Translational Neurodegeneration 2018 7:10

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  6. Content type: Review

    Brain 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been utilized to monitor disease conversion from amnestic mild cognitive impairment (aMCI) to Alzheimer’s dementia (AD). However, the conver...

    Authors: Hai Rong Ma, Li Qin Sheng, Ping Lei Pan, Gen Di Wang, Rong Luo, Hai Cun Shi, Zhen Yu Dai and Jian Guo Zhong

    Citation: Translational Neurodegeneration 2018 7:9

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  7. Content type: Review

    Parkinson’s disease (PD) is often accompanied by clinically identified depression. Providing effective pharmacotherapies that concomitantly treat both motor and psychological symptoms can pose a challenge to p...

    Authors: Alexandra M. Lesenskyj, Megan P. Samples, Jill M. Farmer and Christina R. Maxwell

    Citation: Translational Neurodegeneration 2018 7:8

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  8. Content type: Review

    Animal models of exercise and Parkinson’s disease (PD) have found that the physiologic use of exercise may interact with the neurodegenerative disease process, likely mediated by brain derived neurotrophic fac...

    Authors: Mark A. Hirsch, Erwin E. H. van Wegen, Mark A. Newman and Patricia C. Heyn

    Citation: Translational Neurodegeneration 2018 7:7

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  9. Content type: Short report

    Tauopathies comprise a family of neurodegenerative disorders including Alzheimer’s disease for which there is an urgent and unmet need for disease-modifying treatments. Tauopathies are characterized by patholo...

    Authors: Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J. Weiss, Yitzhak Tor, Jeffrey D. Esko and Nadia Soussi-Yanicostas

    Citation: Translational Neurodegeneration 2018 7:6

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  10. Content type: Review

    Nearly 30% of adults 40 years and older in the United States are on a statin. Their widespread use heightens the importance of careful consideration of their varied effects on the body. Although randomized con...

    Authors: Bob G. Schultz, Denise K. Patten and Daniel J. Berlau

    Citation: Translational Neurodegeneration 2018 7:5

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  11. Content type: Review

    Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly est...

    Authors: Belal Shohayeb, Mohamed Diab, Mazen Ahmed and Dominic Chi Hiung Ng

    Citation: Translational Neurodegeneration 2018 7:4

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  12. Content type: Review

    Hydrogen Sulfide (H2S) and Nitric Oxide (NO) have become recognized as important gaseous signaling molecules with enormous pharmacological effects, therapeutic value, and central physiological roles. NO is one of...

    Authors: Sandesh Panthi, Sumeet Manandhar and Kripa Gautam

    Citation: Translational Neurodegeneration 2018 7:3

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  13. Content type: Review

    Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extr...

    Authors: Xiaoguang Du, Xinyi Wang and Meiyu Geng

    Citation: Translational Neurodegeneration 2018 7:2

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  14. Content type: Research

    Rapid eye movement sleep behavior disorder (RBD) and Parkinson’s disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. This study aims to confi...

    Authors: Ye Liu, Xiao-Ying Zhu, Xiao-Jin Zhang, Sheng-Han Kuo, William G. Ondo and Yun-Cheng Wu

    Citation: Translational Neurodegeneration 2017 6:35

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  15. Content type: Review

    In this mini-review, we summarize recent findings relating to the prion-like propagation of α-synuclein (α-syn) and the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s dise...

    Authors: Daniel Kam Yin Chan, Ying Hua Xu, Luke Kar Man Chan, Nady Braidy and George D. Mellick

    Citation: Translational Neurodegeneration 2017 6:33

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  16. Content type: Research

    PINK1 (PTEN-induced putative kinase 1) gene is the causal gene for recessive familial type 6 of Parkinson’s disease (PARK6), which is an early-onset autosomal recessive inherited neurodegenerative disease. PIN...

    Authors: Ji-feng Guo, Ling-yan Yao, Qi-ying Sun, Yi-ting Cui, Yang Yang, Qian Xu, Xin-xiang Yan and Bei-sha Tang

    Citation: Translational Neurodegeneration 2017 6:34

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  17. Content type: Review

    Huntington’s Disease (HD) is a genetically dominant trinucleotide repeat disorder resulting from CAG repeats within the Huntingtin (HTT) gene exceeding a normal range (> 36 CAGs). Symptoms of the disease manif...

    Authors: Sebastian Aguiar, Bram van der Gaag and Francesco Albert Bosco Cortese

    Citation: Translational Neurodegeneration 2017 6:30

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  18. Content type: Research

    Tau vaccination and administration of anti-tau antibodies can prevent pathology and cognitive impairment in transgenic mouse models of tauopathy, suggesting that therapies which increase anti-tau antibodies mi...

    Authors: Andrea C. Klaver, Mary P. Coffey, David A. Bennett and David A. Loeffler

    Citation: Translational Neurodegeneration 2017 6:32

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  19. Content type: Research

    Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron disorders. Effective therapeutic strategies are an unmet need for these disorders....

    Authors: Rafael Lazo-Gomez and Ricardo Tapia

    Citation: Translational Neurodegeneration 2017 6:31

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  20. Content type: Research

    Extensive loss of donor neural stem cell (NSCs) due to ischemic stress and low rate of differentiation at the site of cell graft are two of the major issues that hamper optimal outcome in NSCs transplantation ...

    Authors: Parisa Tabeshmehr, Haider Kh Husnain, Mahin Salmannejad, Mahsa Sani, Seyed Mojtaba Hosseini and Mohammad Hossein Khorraminejad Shirazi

    Citation: Translational Neurodegeneration 2017 6:29

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  21. Content type: Review

    Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkins...

    Authors: Panchanan Maiti, Jayeeta Manna and Gary L. Dunbar

    Citation: Translational Neurodegeneration 2017 6:28

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  22. Content type: Review

    The clinical diagnosis of neurodegenerative disorders based on phenotype is difficult in heterogeneous conditions with overlapping symptoms. It does not take into account the disease etiology or the highly var...

    Authors: Shirley Yin-Yu Pang, Kay-Cheong Teo, Jacob Shujui Hsu, Richard Shek-Kwan Chang, Miaoxin Li, Pak-Chung Sham and Shu-Leong Ho

    Citation: Translational Neurodegeneration 2017 6:27

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  23. Content type: Review

    Photophobia is a common symptom seen in many neurologic disorders, however, its pathophysiology remains unclear. Even the term is ambiguous. In this paper, we review the epidemiology and clinical manifestation...

    Authors: Yiwen Wu and Mark Hallett

    Citation: Translational Neurodegeneration 2017 6:26

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