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  1. Review

    The role of gene variants in the pathogenesis of neurodegenerative disorders as revealed by next generation sequencing studies: a review

    The clinical diagnosis of neurodegenerative disorders based on phenotype is difficult in heterogeneous conditions with overlapping symptoms. It does not take into account the disease etiology or the highly var...

    Shirley Yin-Yu Pang, Kay-Cheong Teo, Jacob Shujui Hsu, Richard Shek-Kwan Chang, Miaoxin Li, Pak-Chung Sham and Shu-Leong Ho

    Translational Neurodegeneration 2017 6:27

    Published on: 6 October 2017

  2. Review

    Photophobia in neurologic disorders

    Photophobia is a common symptom seen in many neurologic disorders, however, its pathophysiology remains unclear. Even the term is ambiguous. In this paper, we review the epidemiology and clinical manifestation...

    Yiwen Wu and Mark Hallett

    Translational Neurodegeneration 2017 6:26

    Published on: 20 September 2017

  3. Review

    Mild cognitive impairment in Parkinson’s disease: a distinct clinical entity?

    Mild cognitive impairment in Parkinson’s disease (PD-MCI) is a common clinical condition. Understanding its pathology and clinical features is important for early intervention before the onset of dementia. In ...

    Ming-Ching Wen, Ling Ling Chan, Louis C.S. Tan and Eng King Tan

    Translational Neurodegeneration 2017 6:24

    Published on: 13 September 2017

  4. Review

    Role of BACE1 in Alzheimer’s synaptic function

    Alzheimer’s disease (AD) is the most common age-dependent disease of dementia, and there is currently no cure available. This hallmark pathologies of AD are the presence of amyloid plaques and neurofibrillary ...

    Brati Das and Riqiang Yan

    Translational Neurodegeneration 2017 6:23

    Published on: 30 August 2017

  5. Review

    Nicotine from cigarette smoking and diet and Parkinson disease: a review

    Evidence from epidemiological studies suggest a relationship between cigarette smoking and low risk of Parkinson disease (PD). As a major component of tobacco smoke, nicotine has been proposed to be a substanc...

    Chaoran Ma, Yesong Liu, Samantha Neumann and Xiang Gao

    Translational Neurodegeneration 2017 6:18

    Published on: 2 July 2017

  6. Research

    Caregiver burden is increased in Parkinson’s disease with mild cognitive impairment (PD-MCI)

    There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease (PD-MCI) and the coping strategies used by these caregivers.

    Ann J. Jones, Roeline G. Kuijer, Leslie Livingston, Daniel Myall, Kyla Horne, Michael MacAskill, Toni Pitcher, Paul T. Barrett, Tim J. Anderson and John C. Dalrymple-Alford

    Translational Neurodegeneration 2017 6:17

    Published on: 19 June 2017

  7. Review

    Rest tremor revisited: Parkinson’s disease and other disorders

    Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. Since distinct diseases can cause similar tremor manifestations and vice-versa, it is...

    Wei Chen, Franziska Hopfner, Jos Steffen Becktepe and Günther Deuschl

    Translational Neurodegeneration 2017 6:16

    Published on: 16 June 2017

  8. Research

    Factors predicting the instant effect of motor function after subthalamic nucleus deep brain stimulation in Parkinson’s disease

    Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for Parkinson’s disease (PD), the predictive effect of levodopa responsiveness on surgical outcomes was confirmed by some studies,...

    Xin-Ling Su, Xiao-Guang Luo, Hong Lv, Jun Wang, Yan Ren and Zhi-Yi He

    Translational Neurodegeneration 2017 6:14

    Published on: 26 May 2017

  9. Research

    Mesencephalic astrocyte-derived neurotrophic factor reduces cell apoptosis via upregulating HSP70 in SHSY-5Y cells

    Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a new candidate growth factor for dopaminergic neurons against endoplasmic reticulum stress (ER stress). HSP70 family, a chaperon like heat shock p...

    Hui Sun, Ming Jiang, Xing Fu, Qiong Cai, Jingxing Zhang, Yanxin Yin, Jia Guo, Lihua Yu, Yun Jiang, Yigang Liu, Liang Feng, Zhiyu Nie, Jianmin Fang and Lingjing Jin

    Translational Neurodegeneration 2017 6:12

    Published on: 22 May 2017

  10. Review

    Effect of low versus high frequency stimulation on freezing of gait and other axial symptoms in Parkinson patients with bilateral STN DBS: a mini-review

    Some studies have shown that low frequency stimulation (LFS, most commonly 60 Hz), compared to high frequency stimulation (HFS, most commonly 130 Hz), has beneficial effects, short-term or even long-term, on i...

    Tao Xie, Mahesh Padmanaban, Lisa Bloom, Ellen MacCracken, Breanna Bertacchi, Abraham Dachman and Peter Warnke

    Translational Neurodegeneration 2017 6:13

    Published on: 17 May 2017

  11. Research

    Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration

    Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis, which converts glutamine into glutamate. Glutamate is the major neurotransmitter of excitatory synapses,...

    Yuju Li, Justin Peer, Runze Zhao, Yinghua Xu, Beiqing Wu, Yi Wang, Changhai Tian, Yunlong Huang and Jialin Zheng

    Translational Neurodegeneration 2017 6:10

    Published on: 20 April 2017

  12. Review

    Imaging biomarkers in Parkinson’s disease and Parkinsonian syndromes: current and emerging concepts

    Two centuries ago in 1817, James Parkinson provided the first medical description of Parkinson’s disease, later refined by Jean-Martin Charcot in the mid-to-late 19th century to include the atypical parkinsoni...

    Usman Saeed, Jordana Compagnone, Richard I. Aviv, Antonio P. Strafella, Sandra E. Black, Anthony E. Lang and Mario Masellis

    Translational Neurodegeneration 2017 6:8

    Published on: 28 March 2017

  13. Review

    Protein misfolding in neurodegenerative diseases: implications and strategies

    A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse. Therapeutic options are currently...

    Patrick Sweeney, Hyunsun Park, Marc Baumann, John Dunlop, Judith Frydman, Ron Kopito, Alexander McCampbell, Gabrielle Leblanc, Anjli Venkateswaran, Antti Nurmi and Robert Hodgson

    Translational Neurodegeneration 2017 6:6

    Published on: 13 March 2017

  14. Review

    The role of exosomes in the pathogenesis of Alzheimer’ disease

    Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular componen...

    Tingting Xiao, Weiwei Zhang, Bin Jiao, Chu-Zheng Pan, Xixi Liu and Lu Shen

    Translational Neurodegeneration 2017 6:3

    Published on: 2 February 2017

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