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  1. Early morning off (EMO) is a common feature of Parkinson’s disease (PD). This study aimed to characterize its clinical features and develop a convenient and pragmatic self-assessment instrument in a Chinese na...

    Authors: Chao Han, Wei Mao, Jing An, Lifei Jiao and Piu Chan

    Citation: Translational Neurodegeneration 2020 9:29

    Content type: Research

    Published on:

  2. MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases. Overexpressed miRNAs play an important ro...

    Authors: Ki Yoon Kim, Yu Ri Kim, Kyung Won Choi, Mijung Lee, Somyung Lee, Wooseok Im, Je-Young Shin, Jin Young Kim, Yoon Ho Hong, Manho Kim, Jong-Il Kim and Jung-Joon Sung

    Citation: Translational Neurodegeneration 2020 9:23

    Content type: Research

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  3. The clinical presentations of frontotemporal dementia (FTD) are diverse and overlap with other neurological disorders. There are, as of today, no biomarkers in clinical practice for diagnosing the disorders. H...

    Authors: Julia Remnestål, Linn Öijerstedt, Abbe Ullgren, Jennie Olofsson, Sofia Bergström, Kim Kultima, Martin Ingelsson, Lena Kilander, Mathias Uhlén, Anna Månberg, Caroline Graff and Peter Nilsson

    Citation: Translational Neurodegeneration 2020 9:27

    Content type: Research

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  4. In Alzheimer’s Disease (AD), about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways. Among them, the Ras and Rab Interactor 3(RIN3) is a guan...

    Authors: Ruinan Shen, Xiaobei Zhao, Lu He, Yongbo Ding, Wei Xu, Suzhen Lin, Savannah Fang, Wanlin Yang, Kijung Sung, Brian Spencer, Robert A. Rissman, Ming Lei, Jianqing Ding and Chengbiao Wu

    Citation: Translational Neurodegeneration 2020 9:26

    Content type: Research

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  5. An amendment to this paper has been published and can be accessed via the original article.

    Authors: William R. Swindell, Krzysztof Bojanowski, Mark S. Kindy, Raymond M. W. Chau and Dorothy Ko

    Citation: Translational Neurodegeneration 2020 9:24

    Content type: Correction

    Published on:

    The original article was published in Translational Neurodegeneration 2018 7:30

  6. Alzheimer’s and Parkinson’s diseases are the most prevalent neurodegenerative disorders. Their etiologies are idiopathic, and treatments are symptomatic and orientated towards cognitive or motor deficits. Neur...

    Authors: Isabel Ubeda-Bañon, Daniel Saiz-Sanchez, Alicia Flores-Cuadrado, Ernesto Rioja-Corroto, Melania Gonzalez-Rodriguez, Sandra Villar-Conde, Veronica Astillero-Lopez, Juan Pablo Cabello-de la Rosa, Maria Jose Gallardo-Alcañiz, Julia Vaamonde-Gamo, Fernanda Relea-Calatayud, Lucia Gonzalez-Lopez, Alicia Mohedano-Moriano, Alberto Rabano and Alino Martinez-Marcos

    Citation: Translational Neurodegeneration 2020 9:22

    Content type: Review

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  7. Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and oxidative stress, which are important factors contributing to the development of brain disease. Ample evidence suggests ...

    Authors: Luodan Yang, Hannah Youngblood, Chongyun Wu and Quanguang Zhang

    Citation: Translational Neurodegeneration 2020 9:19

    Content type: Review

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  8. Subjective cognitive decline (SCD) is a preclinical stage along the Alzheimer’s disease (AD) continuum. However, little is known about the aberrant patterns of connectivity and topological alterations of the b...

    Authors: Haifeng Chen, Xiaoning Sheng, Caimei Luo, Ruomeng Qin, Qing Ye, Hui Zhao, Yun Xu and Feng Bai

    Citation: Translational Neurodegeneration 2020 9:21

    Content type: Research

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  9. Alzheimer’s disease is a neurodegenerative disorder. Therapeutically, a transplantation of bone marrow mesenchymal stem cells (BMMSCs) can play a beneficial role in animal models of Alzheimer’s disease. Howeve...

    Authors: Chuan Qin, Yalan Lu, Kewei Wang, Lin Bai, Guiying Shi, Yiying Huang and Yongning Li

    Citation: Translational Neurodegeneration 2020 9:20

    Content type: Review

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  10. Neuropsychiatric symptoms (NPS) such as depression, anxiety, apathy, and irritability occur in prodromal phases of clinical Alzheimer’s disease (AD), which might be an increased risk for later developing AD. H...

    Authors: Peng-Hui Ai, Si Chen, Xian-Dong Liu, Xiao-Na Zhu, Yuan-Bo Pan, Dong-Fu Feng, Shengdi Chen, Nan-Jie Xu and Suya Sun

    Citation: Translational Neurodegeneration 2020 9:18

    Content type: Research

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  11. Alzheimer’s disease (AD) is the most common type of dementia, and no disease-modifying treatments are available to halt or slow its progression. Amyloid-beta (Aβ) is suggested to play a pivotal role in the pat...

    Authors: Yuan Cheng, Ding-Yuan Tian and Yan-Jiang Wang

    Citation: Translational Neurodegeneration 2020 9:16

    Content type: Review

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  12. Asymptomatic carriers of leucine-rich repeat kinase 2 (LRRK2) gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson’s disease (PD). In this study, we aim to identify CSF ...

    Authors: Nour K. Majbour, Jan O. Aasly, Eldbjørg Hustad, Mercy A. Thomas, Nishant N. Vaikath, Naser Elkum, Wilma D. J. van de Berg, Takahiko Tokuda, Brit Mollenhauer, Henk W. Berendse and Omar M. A. El-Agnaf

    Citation: Translational Neurodegeneration 2020 9:15

    Content type: Research

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  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Heinz Reichmann, Andrew Lees, José-Francisco Rocha, Diogo Magalhães and Patrício Soares-da-Silva

    Citation: Translational Neurodegeneration 2020 9:14

    Content type: Correction

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    The original article was published in Translational Neurodegeneration 2020 9:9

  14. Parkinson’s disease (PD) is one of the neurodegeneration diseases characterized by the gradual loss of dopaminergic (DA) neurons in the substantia nigra region of the brain. Substantial evidence indicates that...

    Authors: Xiao-Yu Cheng, Sangita Biswas, Juan Li, Cheng-Jie Mao, Olga Chechneva, Jing Chen, Kai Li, Jiao Li, Jin-Ru Zhang, Chun-Feng Liu and Wen-Bin Deng

    Citation: Translational Neurodegeneration 2020 9:13

    Content type: Research

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  15. The identification of circulating biomarkers that closely correlate with Parkinson’s Disease (PD) has failed several times in the past. Nevertheless, in this pilot study, a translational approach was conducted...

    Authors: Sandra I. Anjo, Patrícia Valério dos Santos, Luiza Rosado, Graça Baltazar, Inês Baldeiras, Diana Pires, Andreia Gomes, Cristina Januário, Miguel Castelo-Branco, Mário Grãos and Bruno Manadas

    Citation: Translational Neurodegeneration 2020 9:11

    Content type: Research

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  16. The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the brain is crucial for maintaining normal physiological functions. Studies have shown that imbalance of these metal ions in the brain...

    Authors: Lu Wang, Ya-Ling Yin, Xin-Zi Liu, Peng Shen, Yan-Ge Zheng, Xin-Rui Lan, Cheng-Biao Lu and Jian-Zhi Wang

    Citation: Translational Neurodegeneration 2020 9:10

    Content type: Review

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  17. The efficacy and safety of opicapone, a once-daily catechol-O-methyltransferase inhibitor, have been established in two large randomized, placebo-controlled, multinational pivotal trials. Still, clinical evide...

    Authors: Heinz Reichmann, Andrew Lees, José-Francisco Rocha, Diogo Magalhães and Patrício Soares-da-Silva

    Citation: Translational Neurodegeneration 2020 9:9

    Content type: Research

    Published on:

    The Correction to this article has been published in Translational Neurodegeneration 2020 9:14

  18. Older African Americans are more likely to develop Alzheimer’s disease (AD) than older Caucasians, and this difference cannot be readily explained by cerebrovascular and socioeconomic factors alone. We previou...

    Authors: Maria B. Misiura, J. Christina Howell, Junjie Wu, Deqiang Qiu, Monica W. Parker, Jessica A. Turner and William T. Hu

    Citation: Translational Neurodegeneration 2020 9:8

    Content type: Research

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  19. Multiple system atrophy (MSA) is a debilitating and fatal neurodegenerative disorder. The disease severity warrants urgent development of disease-modifying therapy, but the disease pathogenesis is still enigma...

    Authors: Seiji Kaji, Takakuni Maki, Tomoyuki Ishimoto, Hodaka Yamakado and Ryosuke Takahashi

    Citation: Translational Neurodegeneration 2020 9:7

    Content type: Review

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  20. The direct reprogramming of somatic cells into induced neural progenitor cells (iNPCs) has been envisioned as a promising approach to overcome ethical and clinical issues of pluripotent stem cell transplantati...

    Authors: Xiaohuan Xia, Chunhong Li, Yi Wang, Xiaobei Deng, Yizhao Ma, Lu Ding and Jialin Zheng

    Citation: Translational Neurodegeneration 2020 9:6

    Content type: Short report

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  21. α-Synuclein is a small soluble protein, whose physiological function in the healthy brain is poorly understood. Intracellular inclusions of α-synuclein, referred to as Lewy bodies (LBs), are pathological hallm...

    Authors: Niccolo Candelise, Matthias Schmitz, Katrin Thüne, Maria Cramm, Alberto Rabano, Saima Zafar, Erik Stoops, Hugo Vanderstichele, Anna Villar-Pique, Franc Llorens and Inga Zerr

    Citation: Translational Neurodegeneration 2020 9:5

    Content type: Review

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  22. Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder characterized by the presence of multiple motor and vocal tics. TS usually co-occurs with one or multiple psychiatric disorders. Although b...

    Authors: Wenying Xu, Chencheng Zhang, Wissam Deeb, Bhavana Patel, Yiwen Wu, Valerie Voon, Michael S. Okun and Bomin Sun

    Citation: Translational Neurodegeneration 2020 9:4

    Content type: Review

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  23. In the original publication of this article [1], the following statement should be added in the Acknowledgement section.

    Authors: Jeroen Van Schependom, Kaat Guldolf, Marie Béatrice D’hooghe, Guy Nagels and Miguel D’haeseleer

    Citation: Translational Neurodegeneration 2020 9:3

    Content type: Correction

    Published on:

    The original article was published in Translational Neurodegeneration 2019 8:37

  24. Parkinson’s disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, mo...

    Authors: Caroline Haikal, Qian-Qian Chen and Jia-Yi Li

    Citation: Translational Neurodegeneration 2019 8:38

    Content type: Review

    Published on:

  25. Multiple sclerosis (MS) is a complex chronic inflammatory and degenerative disorder of the central nervous system. Accelerated brain volume loss, or also termed atrophy, is currently emerging as a popular imag...

    Authors: Jeroen Van Schependom, Kaat Guldolf, Marie Béatrice D’hooghe, Guy Nagels and Miguel D’haeseleer

    Citation: Translational Neurodegeneration 2019 8:37

    Content type: Review

    Published on:

    The Correction to this article has been published in Translational Neurodegeneration 2020 9:3

  26. We recently demonstrated an endolysosomal accumulation of the β-secretase-derived APP C-terminal fragment (CTF) C99 in brains of Alzheimer disease (AD) mouse models. Moreover, we showed that the treatment with...

    Authors: Inger Lauritzen, Anaïs Bécot, Alexandre Bourgeois, Raphaëlle Pardossi-Piquard, Maria-Grazia Biferi, Martine Barkats and Fréderic Checler

    Citation: Translational Neurodegeneration 2019 8:35

    Content type: Research

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  27. CSF1R-related leukoencephalopathy, also known as hereditary diffuse leukoencephalopathy with spheroids (HDLS), is a rare white-matter encephalopathy characterized by motor and neuropsychiatric symptoms due to col...

    Authors: Wo-Tu Tian, Fei-Xia Zhan, Qing Liu, Xing-Hua Luan, Chao Zhang, Liang Shang, Ben-Yan Zhang, Si-Jian Pan, Fei Miao, Jiong Hu, Ping Zhong, Shi-Hua Liu, Ze-Yu Zhu, Hai-Yan Zhou, Suya Sun, Xiao-Li Liu…

    Citation: Translational Neurodegeneration 2019 8:32

    Content type: Research

    Published on:

  28. Different oscillations of brain networks could carry different dimensions of brain integration. We aimed to investigate oscillation-specific nodal alterations in patients with Parkinson’s disease (PD) across e...

    Authors: Xiaojun Guan, Tao Guo, Qiaoling Zeng, Jiaqiu Wang, Cheng Zhou, Chunlei Liu, Hongjiang Wei, Yuyao Zhang, Min Xuan, Quanquan Gu, Xiaojun Xu, Peiyu Huang, Jiali Pu, Baorong Zhang and Min-Ming Zhang

    Citation: Translational Neurodegeneration 2019 8:36

    Content type: Research

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  29. Previous studies have shown that expression levels of miR-181c are downregulated by amyloid-β (Aβ) deposition and chronic cerebral hypoperfusion, both factors largely associated with the development of AD. Mor...

    Authors: Marta Manzano-Crespo, Mercedes Atienza and Jose L. Cantero

    Citation: Translational Neurodegeneration 2019 8:34

    Content type: Research

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  30. We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice.

    Authors: Luís Costa-Marques, Katrin Arnold, Marie-Christine Pardon, Christiane Leovsky, Samantha Swarbrick, Claire Fabian and Alexandra Stolzing

    Citation: Translational Neurodegeneration 2019 8:33

    Content type: Research

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  31. Because of the increasing life expectancy in our society, aging-related neurodegenerative disorders are one of the main issues in global health. Most of these diseases are characterized by the deposition of mi...

    Authors: Ana Gámez-Valero, Jaume Campdelacreu, Dolores Vilas, Lourdes Ispierto, Ramón Reñé, Ramiro Álvarez, M. Pilar Armengol, Francesc E. Borràs and Katrin Beyer

    Citation: Translational Neurodegeneration 2019 8:31

    Content type: Research

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  32. Neuroinflammation and accumulation of β-amyloid (Aβ) play a significant role in the onset and progression of Alzheimer’s disease (AD). Our previous study demonstrated that signal transducer and activator of tr...

    Authors: Hyeon Joo Ham, Sang-Bae Han, Jaesuk Yun, In Jun Yeo, Young Wan Ham, Se Hyun Kim, Pil-Hoon Park, Dong-Young Choi and Jin Tae Hong

    Citation: Translational Neurodegeneration 2019 8:26

    Content type: Research

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  33. A great body of evidence suggests that there are retinal functional and structural changes that occur in Alzheimer’s disease (AD). However, whether such changes are primary or secondary remains to be elucidate...

    Authors: Dana Georgevsky, Stephanie Retsas, Newsha Raoufi, Olga Shimoni and S. Mojtaba Golzan

    Citation: Translational Neurodegeneration 2019 8:30

    Content type: Research

    Published on:

  34. Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disorder caused by the expansion of CAG repeats in ATXN1 gene resulting in an expansion of polyglutamine repeats in the ATXN1 protei...

    Authors: Pei-Jiun Tsai, Chang-Ching Yeh, Wan-Jhen Huang, Ming-Yuan Min, Tzu-Hao Huang, Tsui-Ling Ko, Pei-Yu Huang, Tien-Hua Chen, Sanford P. C. Hsu, Bing-Wen Soong and Yu-Show Fu

    Citation: Translational Neurodegeneration 2019 8:29

    Content type: Research

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  35. The fundamental role that alpha-synuclein (aSyn) plays in the pathogenesis of neurodegenerative synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, is a we...

    Authors: Naomi P. Visanji, Anthony E. Lang and Gabor G. Kovacs

    Citation: Translational Neurodegeneration 2019 8:28

    Content type: Review

    Published on:

  36. In vivo diffusion tensor imaging (DTI) of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis (ALS).

    Authors: Hans-Peter Müller, David Brenner, Francesco Roselli, Diana Wiesner, Alireza Abaei, Martin Gorges, Karin M. Danzer, Albert C. Ludolph, William Tsao, Philip C. Wong, Volker Rasche, Jochen H. Weishaupt and Jan Kassubek

    Citation: Translational Neurodegeneration 2019 8:27

    Content type: Research

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  37. Alterations in the expression of human kallikrein-related peptidases (KLKs) have been described in patients with Alzheimer’s disease (AD). We elucidated the suitability of KLK6, KLK8 and KLK10 to distinguish A...

    Authors: Oliver Goldhardt, Inanna Warnhoff, Igor Yakushev, Ilijana Begcevic, Hans Förstl, Viktor Magdolen, Antoninus Soosaipillai, Eleftherios Diamandis, Panagiotis Alexopoulos and Timo Grimmer

    Citation: Translational Neurodegeneration 2019 8:25

    Content type: Research

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  38. Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During the course of disease, misfolded α-syn...

    Authors: Shirley Yin-Yu Pang, Philip Wing-Lok Ho, Hui-Fang Liu, Chi-Ting Leung, Lingfei Li, Eunice Eun Seo Chang, David Boyer Ramsden and Shu-Leong Ho

    Citation: Translational Neurodegeneration 2019 8:23

    Content type: Review

    Published on:

  39. Parkinson’s disease (PD) is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative parkinsonisms. PD is characterized by intraneuronal accumulatio...

    Authors: Chiara Maria Giulia De Luca, Antonio Emanuele Elia, Sara Maria Portaleone, Federico Angelo Cazzaniga, Martina Rossi, Edoardo Bistaffa, Elena De Cecco, Joanna Narkiewicz, Giulia Salzano, Olga Carletta, Luigi Romito, Grazia Devigili, Paola Soliveri, Pietro Tiraboschi, Giuseppe Legname, Fabrizio Tagliavini…

    Citation: Translational Neurodegeneration 2019 8:24

    Content type: Research

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  40. The number and health burden of Parkinson’s disease increase rapidly in China. It is estimated that China will have nearly half of the Parkinson’s disease population in the world in 2030. In this review, we pr...

    Authors: Gen Li, Jianfang Ma, Shishuang Cui, Yixi He, Qin Xiao, Jun Liu and Shengdi Chen

    Citation: Translational Neurodegeneration 2019 8:22

    Content type: Review

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  41. Although many causative genes of hereditary spastic paraplegia (HSP) have been uncovered in recent years, there are still approximately 50% of HSP patients without genetically diagnosis, especially in autosoma...

    Authors: Qiao Wei, Hai-Lin Dong, Li-Ying Pan, Cong-Xin Chen, Yang-Tian Yan, Rou-Min Wang, Hong-Fu Li, Zhi-Jun Liu, Qing-Qing Tao and Zhi-Ying Wu

    Citation: Translational Neurodegeneration 2019 8:19

    Content type: Research

    Published on:

  42. Progressive accumulation of α-synuclein is a key step in the pathological development of Parkinson’s disease. Impaired protein degradation and increased levels of α-synuclein may trigger a pathological aggrega...

    Authors: Jia-Zhen Wu, Mustafa Ardah, Caroline Haikal, Alexander Svanbergsson, Meike Diepenbroek, Nishant N. Vaikath, Wen Li, Zhan-You Wang, Tiago F. Outeiro, Omar M. El-Agnaf and Jia-Yi Li

    Citation: Translational Neurodegeneration 2019 8:18

    Content type: Research

    Published on:

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