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  1. Currently, there is no cure for Alzheimer’s disease (AD). Therapeutics that can modify the early stage of AD are urgently needed. Recent studies have shown that the pathogenesis of AD is closely regulated by a...

    Authors: Ju Wang, Hui-Jie Hu, Zi-Kai Liu, Jing-Jing Liu, Shan-Shan Wang, Qing Cheng, Hong-Zhuan Chen and Mingke Song

    Citation: Translational Neurodegeneration 2021 10:12

    Content type: Research

    Published on:

  2. The development of in vivo biomarkers of Alzheimer’s disease (AD) has advanced the diagnosis of AD from a clinical syndrome to a biological construct. The preclinical stage of AD continuum is defined by the id...

    Authors: Kok Pin Ng, Hui Chiew, Pedro Rosa-Neto, Nagaendran Kandiah, Zahinoor Ismail and Serge Gauthier

    Citation: Translational Neurodegeneration 2021 10:11

    Content type: Review

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  3. A lack of convenient and reliable biomarkers for diagnosis and prognosis is a common challenge for neurodegenerative diseases such as Alzheimer’s disease (AD). Recent advancement in ultrasensitive protein assa...

    Authors: Xulong Ding, Shuting Zhang, Lijun Jiang, Lu Wang, Tao Li and Peng Lei

    Citation: Translational Neurodegeneration 2021 10:10

    Content type: Review

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  4. α-Synuclein has been studied as a potential biomarker for Parkinson’s disease (PD) with no concluding results. Accordingly, there is an urgent need to find out reliable specific biomarkers for PD. GPR37 is an ...

    Authors: Xavier Morató, Paula Garcia-Esparcia, Josep Argerich, Franc Llorens, Inga Zerr, Wojciech Paslawski, Eva Borràs, Eduard Sabidó, Ulla E. Petäjä-Repo, Víctor Fernández-Dueñas, Isidro Ferrer, Per Svenningsson and Francisco Ciruela

    Citation: Translational Neurodegeneration 2021 10:8

    Content type: Research

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  5. Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes. Paroxysmal kinesigenic dyskinesia (PKD) is the most common typ...

    Authors: Li Cao, Xiaojun Huang, Ning Wang, Zhiying Wu, Cheng Zhang, Weihong Gu, Shuyan Cong, Jianhua Ma, Ling Wei, Yanchun Deng, Qi Fang, Qi Niu, Jin Wang, Zhaoxia Wang, You Yin, Jinyong Tian…

    Citation: Translational Neurodegeneration 2021 10:7

    Content type: Review

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  6. As the most common form of dementia, Alzheimer’s disease (AD) is characterized by progressive cognitive impairments and constitutes a major social burden. Currently, the invasiveness and high costs of tests ha...

    Authors: Ying Zhang, Yanjiang Wang, Ce Shi, Meixiao Shen and Fan Lu

    Citation: Translational Neurodegeneration 2021 10:6

    Content type: Review

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  7. The familial form of Parkinson’s disease (PD) is linked to mutations in specific genes. The mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active...

    Authors: Iryna Kamienieva, Jerzy Duszyński and Joanna Szczepanowska

    Citation: Translational Neurodegeneration 2021 10:5

    Content type: Review

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  8. Current therapies for Parkinson’s disease (PD) are palliative, of which the levodopa/carbidopa therapy remains the primary choice but is unable to modulate the progression of neurodegeneration. Due to the comp...

    Authors: Tapan Behl, Gagandeep Kaur, Ovidiu Fratila, Camelia Buhas, Claudia Teodora Judea-Pusta, Nicoleta Negrut, Cristiana Bustea and Simona Bungau

    Citation: Translational Neurodegeneration 2021 10:4

    Content type: Review

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  9. Accumulating evidence has suggested that the pathological changes in amyotrophic lateral sclerosis (ALS) are not only confined to the central nervous system but also occur in the peripheral circulating system....

    Authors: Yangfan Cheng, Yongping Chen and Huifang Shang

    Citation: Translational Neurodegeneration 2021 10:3

    Content type: Review

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  10. Neuropsychiatric symptoms (NPS) are increasingly recognized as early non-cognitive manifestations in the Alzheimer’s disease (AD) continuum. However, the role of NPS as an early marker of pathophysiological pr...

    Authors: Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Yiong Huak Chan, Lai Jiang, Joseph Therriault, Andrea L. Benedet, Monica Shin, Nagaendran Kandiah, Celia M. T. Greenwood, Pedro Rosa-Neto and Serge Gauthier

    Citation: Translational Neurodegeneration 2021 10:1

    Content type: Research

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  11. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J. Weiss, Yitzhak Tor, Jeffrey D. Esko and Nadia Soussi-Yanicostas

    Citation: Translational Neurodegeneration 2020 9:45

    Content type: Correction

    Published on:

    The original article was published in Translational Neurodegeneration 2018 7:6

  12. Deficits in synaptic transmission and plasticity are thought to contribute to the pathophysiology of Alzheimer’s disease (AD) and Parkinson’s disease (PD). Several brain stimulation techniques are currently av...

    Authors: Ti-Fei Yuan, Wei-Guang Li, Chencheng Zhang, Hongjiang Wei, Suya Sun, Nan-Jie Xu, Jun Liu and Tian-Le Xu

    Citation: Translational Neurodegeneration 2020 9:44

    Content type: Review

    Published on:

  13. Parkinson’s disease (PD) is diagnosed when patients exhibit bradykinesia with tremor and/or rigidity, and when these symptoms respond to dopaminergic medications. Yet in the last years there was a greater reco...

    Authors: Elisabeth Dinter, Theodora Saridaki, Leonie Diederichs, Heinz Reichmann and Björn H. Falkenburger

    Citation: Translational Neurodegeneration 2020 9:43

    Content type: Review

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  14. Accumulating reports have suggested that α-synuclein is involved in the pathogenesis of Alzheimer’s disease (AD). As the cerebrospinal fluid (CSF) α-synuclein has been suggested as a potential biomarker of AD,...

    Authors: Jie-Qiong Li, Yan-Lin Bi, Xue-Ning Shen, Hui-Fu Wang, Wei Xu, Chen-Chen Tan, Qiang Dong, Yan-Jiang Wang, Lan Tan and Jin-Tai Yu

    Citation: Translational Neurodegeneration 2020 9:41

    Content type: Research

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  15. Mitochondria are the energy center of cell operations and are involved in physiological functions and maintenance of metabolic balance and homeostasis in the body. Alterations of mitochondrial function are ass...

    Authors: Chunhui Huang, Sen Yan and Zaijun Zhang

    Citation: Translational Neurodegeneration 2020 9:40

    Content type: Review

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  16. Parkinson’s disease (PD) is characterized by motor deficits and a wide variety of non-motor symptoms. The age of onset, rate of disease progression and the precise profile of motor and non-motor symptoms displ...

    Authors: Christian U. von Linstow, Ziv Gan-Or and Patrik Brundin

    Citation: Translational Neurodegeneration 2020 9:39

    Content type: Review

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  17. Misfolded oligomeric α-synuclein plays a pivotal role in the pathogenesis of α-synucleinopathies including Parkinson’s disease and multiple system atrophy, and its detection parallels activation of microglia a...

    Authors: Miguel Lemos, Serena Venezia, Violetta Refolo, Antonio Heras-Garvin, Sabine Schmidhuber, Armin Giese, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Gergana Galabova, Guenther Staffler, Gregor Karl Wenning and Nadia Stefanova

    Citation: Translational Neurodegeneration 2020 9:38

    Content type: Research

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  18. Alzheimer’s disease (AD) immunotherapy with antibodies targeting amyloid-β (Aβ) has been extensively explored in clinical trials. The aim of this study was to study the long-term brain distribution of two radi...

    Authors: Tobias Gustavsson, Stina Syvänen, Paul O’Callaghan and Dag Sehlin

    Citation: Translational Neurodegeneration 2020 9:37

    Content type: Research

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  19. There is an urgent need to understand the pathways and processes underlying Alzheimer’s disease (AD) for early diagnosis and development of effective treatments. This study was aimed to investigate Alzheimer’s...

    Authors: Jin Xu, Giulia Bankov, Min Kim, Asger Wretlind, Jodie Lord, Rebecca Green, Angela Hodges, Abdul Hye, Dag Aarsland, Latha Velayudhan, Richard J. B. Dobson, Petroula Proitsi and Cristina Legido-Quigley

    Citation: Translational Neurodegeneration 2020 9:36

    Content type: Research

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  20. Circular RNAs (circRNAs) are a type of covalently closed, single-stranded circular noncoding RNA that can affect the expression of many protein-coding genes. Growing evidence has shown that circRNAs play criti...

    Authors: Yuan Zhang, Yanfang Zhao, Ying Liu, Man Wang, Wanpeng Yu and Lei Zhang

    Citation: Translational Neurodegeneration 2020 9:35

    Content type: Review

    Published on:

  21. In recent years, many studies have investigated the correlations between Parkinson’s disease (PD) and vitamin D status, but the conclusion remains elusive. The present review focuses on the associations betwee...

    Authors: Lingling Lv, Xuling Tan, Xinke Peng, Rongrong Bai, Qile Xiao, Ting Zou, Jieqiong Tan, Hainan Zhang and Chunyu Wang

    Citation: Translational Neurodegeneration 2020 9:34

    Content type: Review

    Published on:

  22. Common and rare variants of guanosine triphosphate cyclohydrolase 1 (GCH1) gene may play important roles in Parkinson’s disease (PD). However, there is a lack of comprehensive analysis of GCH1 genotypes, especial...

    Authors: Hong-xu Pan, Yu-wen Zhao, Jun-pu Mei, Zheng-huan Fang, Yige Wang, Xun Zhou, Yang-jie Zhou, Rui Zhang, Kai-lin Zhang, Li Jiang, Qian Zeng, Yan He, Zheng Wang, Zhen-hua Liu, Qian Xu, Qi-ying Sun…

    Citation: Translational Neurodegeneration 2020 9:31

    Content type: Research

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  23. Diseases and disorders with a chronic neuroinflammatory component are often linked with changes in brain metabolism. Among neurodegenerative disorders, people living with human immunodeficiency virus (HIV) and...

    Authors: Kalimuthusamy Natarajaseenivasan, Santhanam Shanmughapriya, Prema Velusamy, Matthew Sayre, Alvaro Garcia, Nestor Mas Gomez and Dianne Langford

    Citation: Translational Neurodegeneration 2020 9:32

    Content type: Research

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  24. Progression of mild cognitive impairment (MCI) to Alzheimer’s disease (AD) dementia can be predicted by clinical features and a combination of biomarkers may increase the predictive power. In the present study...

    Authors: Aonan Zhao, Yuanyuan Li, Yi Yan, Yinghui Qiu, Binyin Li, Wei Xu, Ying Wang, Jun Liu and Yulei Deng

    Citation: Translational Neurodegeneration 2020 9:30

    Content type: Research

    Published on:

  25. Early morning off (EMO) is a common feature of Parkinson’s disease (PD). This study aimed to characterize its clinical features and develop a convenient and pragmatic self-assessment instrument in a Chinese na...

    Authors: Chao Han, Wei Mao, Jing An, Lifei Jiao and Piu Chan

    Citation: Translational Neurodegeneration 2020 9:29

    Content type: Research

    Published on:

  26. MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases. Overexpressed miRNAs play an important ro...

    Authors: Ki Yoon Kim, Yu Ri Kim, Kyung Won Choi, Mijung Lee, Somyung Lee, Wooseok Im, Je-Young Shin, Jin Young Kim, Yoon Ho Hong, Manho Kim, Jong-Il Kim and Jung-Joon Sung

    Citation: Translational Neurodegeneration 2020 9:23

    Content type: Research

    Published on:

  27. The clinical presentations of frontotemporal dementia (FTD) are diverse and overlap with other neurological disorders. There are, as of today, no biomarkers in clinical practice for diagnosing the disorders. H...

    Authors: Julia Remnestål, Linn Öijerstedt, Abbe Ullgren, Jennie Olofsson, Sofia Bergström, Kim Kultima, Martin Ingelsson, Lena Kilander, Mathias Uhlén, Anna Månberg, Caroline Graff and Peter Nilsson

    Citation: Translational Neurodegeneration 2020 9:27

    Content type: Research

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  28. In Alzheimer’s Disease (AD), about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways. Among them, the Ras and Rab Interactor 3(RIN3) is a guan...

    Authors: Ruinan Shen, Xiaobei Zhao, Lu He, Yongbo Ding, Wei Xu, Suzhen Lin, Savannah Fang, Wanlin Yang, Kijung Sung, Brian Spencer, Robert A. Rissman, Ming Lei, Jianqing Ding and Chengbiao Wu

    Citation: Translational Neurodegeneration 2020 9:26

    Content type: Research

    Published on:

  29. An amendment to this paper has been published and can be accessed via the original article.

    Authors: William R. Swindell, Krzysztof Bojanowski, Mark S. Kindy, Raymond M. W. Chau and Dorothy Ko

    Citation: Translational Neurodegeneration 2020 9:24

    Content type: Correction

    Published on:

    The original article was published in Translational Neurodegeneration 2018 7:30

  30. Alzheimer’s and Parkinson’s diseases are the most prevalent neurodegenerative disorders. Their etiologies are idiopathic, and treatments are symptomatic and orientated towards cognitive or motor deficits. Neur...

    Authors: Isabel Ubeda-Bañon, Daniel Saiz-Sanchez, Alicia Flores-Cuadrado, Ernesto Rioja-Corroto, Melania Gonzalez-Rodriguez, Sandra Villar-Conde, Veronica Astillero-Lopez, Juan Pablo Cabello-de la Rosa, Maria Jose Gallardo-Alcañiz, Julia Vaamonde-Gamo, Fernanda Relea-Calatayud, Lucia Gonzalez-Lopez, Alicia Mohedano-Moriano, Alberto Rabano and Alino Martinez-Marcos

    Citation: Translational Neurodegeneration 2020 9:22

    Content type: Review

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  31. Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and oxidative stress, which are important factors contributing to the development of brain disease. Ample evidence suggests ...

    Authors: Luodan Yang, Hannah Youngblood, Chongyun Wu and Quanguang Zhang

    Citation: Translational Neurodegeneration 2020 9:19

    Content type: Review

    Published on:

  32. Subjective cognitive decline (SCD) is a preclinical stage along the Alzheimer’s disease (AD) continuum. However, little is known about the aberrant patterns of connectivity and topological alterations of the b...

    Authors: Haifeng Chen, Xiaoning Sheng, Caimei Luo, Ruomeng Qin, Qing Ye, Hui Zhao, Yun Xu and Feng Bai

    Citation: Translational Neurodegeneration 2020 9:21

    Content type: Research

    Published on:

  33. Alzheimer’s disease is a neurodegenerative disorder. Therapeutically, a transplantation of bone marrow mesenchymal stem cells (BMMSCs) can play a beneficial role in animal models of Alzheimer’s disease. Howeve...

    Authors: Chuan Qin, Yalan Lu, Kewei Wang, Lin Bai, Guiying Shi, Yiying Huang and Yongning Li

    Citation: Translational Neurodegeneration 2020 9:20

    Content type: Review

    Published on:

  34. Neuropsychiatric symptoms (NPS) such as depression, anxiety, apathy, and irritability occur in prodromal phases of clinical Alzheimer’s disease (AD), which might be an increased risk for later developing AD. H...

    Authors: Peng-Hui Ai, Si Chen, Xian-Dong Liu, Xiao-Na Zhu, Yuan-Bo Pan, Dong-Fu Feng, Shengdi Chen, Nan-Jie Xu and Suya Sun

    Citation: Translational Neurodegeneration 2020 9:18

    Content type: Research

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  35. Alzheimer’s disease (AD) is the most common type of dementia, and no disease-modifying treatments are available to halt or slow its progression. Amyloid-beta (Aβ) is suggested to play a pivotal role in the pat...

    Authors: Yuan Cheng, Ding-Yuan Tian and Yan-Jiang Wang

    Citation: Translational Neurodegeneration 2020 9:16

    Content type: Review

    Published on:

  36. Asymptomatic carriers of leucine-rich repeat kinase 2 (LRRK2) gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson’s disease (PD). In this study, we aim to identify CSF ...

    Authors: Nour K. Majbour, Jan O. Aasly, Eldbjørg Hustad, Mercy A. Thomas, Nishant N. Vaikath, Naser Elkum, Wilma D. J. van de Berg, Takahiko Tokuda, Brit Mollenhauer, Henk W. Berendse and Omar M. A. El-Agnaf

    Citation: Translational Neurodegeneration 2020 9:15

    Content type: Research

    Published on:

  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Heinz Reichmann, Andrew Lees, José-Francisco Rocha, Diogo Magalhães and Patrício Soares-da-Silva

    Citation: Translational Neurodegeneration 2020 9:14

    Content type: Correction

    Published on:

    The original article was published in Translational Neurodegeneration 2020 9:9

  38. Parkinson’s disease (PD) is one of the neurodegeneration diseases characterized by the gradual loss of dopaminergic (DA) neurons in the substantia nigra region of the brain. Substantial evidence indicates that...

    Authors: Xiao-Yu Cheng, Sangita Biswas, Juan Li, Cheng-Jie Mao, Olga Chechneva, Jing Chen, Kai Li, Jiao Li, Jin-Ru Zhang, Chun-Feng Liu and Wen-Bin Deng

    Citation: Translational Neurodegeneration 2020 9:13

    Content type: Research

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  39. The identification of circulating biomarkers that closely correlate with Parkinson’s Disease (PD) has failed several times in the past. Nevertheless, in this pilot study, a translational approach was conducted...

    Authors: Sandra I. Anjo, Patrícia Valério dos Santos, Luiza Rosado, Graça Baltazar, Inês Baldeiras, Diana Pires, Andreia Gomes, Cristina Januário, Miguel Castelo-Branco, Mário Grãos and Bruno Manadas

    Citation: Translational Neurodegeneration 2020 9:11

    Content type: Research

    Published on:

  40. The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the brain is crucial for maintaining normal physiological functions. Studies have shown that imbalance of these metal ions in the brain...

    Authors: Lu Wang, Ya-Ling Yin, Xin-Zi Liu, Peng Shen, Yan-Ge Zheng, Xin-Rui Lan, Cheng-Biao Lu and Jian-Zhi Wang

    Citation: Translational Neurodegeneration 2020 9:10

    Content type: Review

    Published on:

  41. The efficacy and safety of opicapone, a once-daily catechol-O-methyltransferase inhibitor, have been established in two large randomized, placebo-controlled, multinational pivotal trials. Still, clinical evide...

    Authors: Heinz Reichmann, Andrew Lees, José-Francisco Rocha, Diogo Magalhães and Patrício Soares-da-Silva

    Citation: Translational Neurodegeneration 2020 9:9

    Content type: Research

    Published on:

    The Correction to this article has been published in Translational Neurodegeneration 2020 9:14

  42. Older African Americans are more likely to develop Alzheimer’s disease (AD) than older Caucasians, and this difference cannot be readily explained by cerebrovascular and socioeconomic factors alone. We previou...

    Authors: Maria B. Misiura, J. Christina Howell, Junjie Wu, Deqiang Qiu, Monica W. Parker, Jessica A. Turner and William T. Hu

    Citation: Translational Neurodegeneration 2020 9:8

    Content type: Research

    Published on:

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