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  1. The identification of circulating biomarkers that closely correlate with Parkinson’s Disease (PD) has failed several times in the past. Nevertheless, in this pilot study, a translational approach was conducted...

    Authors: Sandra I. Anjo, Patrícia Valério dos Santos, Luiza Rosado, Graça Baltazar, Inês Baldeiras, Diana Pires, Andreia Gomes, Cristina Januário, Miguel Castelo-Branco, Mário Grãos and Bruno Manadas
    Citation: Translational Neurodegeneration 2020 9:11
  2. The efficacy and safety of opicapone, a once-daily catechol-O-methyltransferase inhibitor, have been established in two large randomized, placebo-controlled, multinational pivotal trials. Still, clinical evide...

    Authors: Heinz Reichmann, Andrew Lees, José-Francisco Rocha, Diogo Magalhães and Patrício Soares-da-Silva
    Citation: Translational Neurodegeneration 2020 9:9

    The Correction to this article has been published in Translational Neurodegeneration 2020 9:14

  3. Older African Americans are more likely to develop Alzheimer’s disease (AD) than older Caucasians, and this difference cannot be readily explained by cerebrovascular and socioeconomic factors alone. We previou...

    Authors: Maria B. Misiura, J. Christina Howell, Junjie Wu, Deqiang Qiu, Monica W. Parker, Jessica A. Turner and William T. Hu
    Citation: Translational Neurodegeneration 2020 9:8
  4. Multiple system atrophy (MSA) is a debilitating and fatal neurodegenerative disorder. The disease severity warrants urgent development of disease-modifying therapy, but the disease pathogenesis is still enigma...

    Authors: Seiji Kaji, Takakuni Maki, Tomoyuki Ishimoto, Hodaka Yamakado and Ryosuke Takahashi
    Citation: Translational Neurodegeneration 2020 9:7
  5. The direct reprogramming of somatic cells into induced neural progenitor cells (iNPCs) has been envisioned as a promising approach to overcome ethical and clinical issues of pluripotent stem cell transplantati...

    Authors: Xiaohuan Xia, Chunhong Li, Yi Wang, Xiaobei Deng, Yizhao Ma, Lu Ding and Jialin Zheng
    Citation: Translational Neurodegeneration 2020 9:6
  6. α-Synuclein is a small soluble protein, whose physiological function in the healthy brain is poorly understood. Intracellular inclusions of α-synuclein, referred to as Lewy bodies (LBs), are pathological hallm...

    Authors: Niccolo Candelise, Matthias Schmitz, Katrin Thüne, Maria Cramm, Alberto Rabano, Saima Zafar, Erik Stoops, Hugo Vanderstichele, Anna Villar-Pique, Franc Llorens and Inga Zerr
    Citation: Translational Neurodegeneration 2020 9:5
  7. Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder characterized by the presence of multiple motor and vocal tics. TS usually co-occurs with one or multiple psychiatric disorders. Although b...

    Authors: Wenying Xu, Chencheng Zhang, Wissam Deeb, Bhavana Patel, Yiwen Wu, Valerie Voon, Michael S. Okun and Bomin Sun
    Citation: Translational Neurodegeneration 2020 9:4
  8. In the original publication of this article [1], the following statement should be added in the Acknowledgement section.

    Authors: Jeroen Van Schependom, Kaat Guldolf, Marie Béatrice D’hooghe, Guy Nagels and Miguel D’haeseleer
    Citation: Translational Neurodegeneration 2020 9:3

    The original article was published in Translational Neurodegeneration 2019 8:37

  9. Parkinson’s disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, mo...

    Authors: Caroline Haikal, Qian-Qian Chen and Jia-Yi Li
    Citation: Translational Neurodegeneration 2019 8:38
  10. Multiple sclerosis (MS) is a complex chronic inflammatory and degenerative disorder of the central nervous system. Accelerated brain volume loss, or also termed atrophy, is currently emerging as a popular imag...

    Authors: Jeroen Van Schependom, Kaat Guldolf, Marie Béatrice D’hooghe, Guy Nagels and Miguel D’haeseleer
    Citation: Translational Neurodegeneration 2019 8:37

    The Correction to this article has been published in Translational Neurodegeneration 2020 9:3

  11. We recently demonstrated an endolysosomal accumulation of the β-secretase-derived APP C-terminal fragment (CTF) C99 in brains of Alzheimer disease (AD) mouse models. Moreover, we showed that the treatment with...

    Authors: Inger Lauritzen, Anaïs Bécot, Alexandre Bourgeois, Raphaëlle Pardossi-Piquard, Maria-Grazia Biferi, Martine Barkats and Fréderic Checler
    Citation: Translational Neurodegeneration 2019 8:35
  12. CSF1R-related leukoencephalopathy, also known as hereditary diffuse leukoencephalopathy with spheroids (HDLS), is a rare white-matter encephalopathy characterized by motor and neuropsychiatric symptoms due to col...

    Authors: Wo-Tu Tian, Fei-Xia Zhan, Qing Liu, Xing-Hua Luan, Chao Zhang, Liang Shang, Ben-Yan Zhang, Si-Jian Pan, Fei Miao, Jiong Hu, Ping Zhong, Shi-Hua Liu, Ze-Yu Zhu, Hai-Yan Zhou, Suya Sun, Xiao-Li Liu…
    Citation: Translational Neurodegeneration 2019 8:32
  13. Different oscillations of brain networks could carry different dimensions of brain integration. We aimed to investigate oscillation-specific nodal alterations in patients with Parkinson’s disease (PD) across e...

    Authors: Xiaojun Guan, Tao Guo, Qiaoling Zeng, Jiaqiu Wang, Cheng Zhou, Chunlei Liu, Hongjiang Wei, Yuyao Zhang, Min Xuan, Quanquan Gu, Xiaojun Xu, Peiyu Huang, Jiali Pu, Baorong Zhang and Min-Ming Zhang
    Citation: Translational Neurodegeneration 2019 8:36
  14. Previous studies have shown that expression levels of miR-181c are downregulated by amyloid-β (Aβ) deposition and chronic cerebral hypoperfusion, both factors largely associated with the development of AD. Mor...

    Authors: Marta Manzano-Crespo, Mercedes Atienza and Jose L. Cantero
    Citation: Translational Neurodegeneration 2019 8:34
  15. We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice.

    Authors: Luís Costa-Marques, Katrin Arnold, Marie-Christine Pardon, Christiane Leovsky, Samantha Swarbrick, Claire Fabian and Alexandra Stolzing
    Citation: Translational Neurodegeneration 2019 8:33
  16. Because of the increasing life expectancy in our society, aging-related neurodegenerative disorders are one of the main issues in global health. Most of these diseases are characterized by the deposition of mi...

    Authors: Ana Gámez-Valero, Jaume Campdelacreu, Dolores Vilas, Lourdes Ispierto, Ramón Reñé, Ramiro Álvarez, M. Pilar Armengol, Francesc E. Borràs and Katrin Beyer
    Citation: Translational Neurodegeneration 2019 8:31
  17. Neuroinflammation and accumulation of β-amyloid (Aβ) play a significant role in the onset and progression of Alzheimer’s disease (AD). Our previous study demonstrated that signal transducer and activator of tr...

    Authors: Hyeon Joo Ham, Sang-Bae Han, Jaesuk Yun, In Jun Yeo, Young Wan Ham, Se Hyun Kim, Pil-Hoon Park, Dong-Young Choi and Jin Tae Hong
    Citation: Translational Neurodegeneration 2019 8:26
  18. A great body of evidence suggests that there are retinal functional and structural changes that occur in Alzheimer’s disease (AD). However, whether such changes are primary or secondary remains to be elucidate...

    Authors: Dana Georgevsky, Stephanie Retsas, Newsha Raoufi, Olga Shimoni and S. Mojtaba Golzan
    Citation: Translational Neurodegeneration 2019 8:30
  19. Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disorder caused by the expansion of CAG repeats in ATXN1 gene resulting in an expansion of polyglutamine repeats in the ATXN1 protei...

    Authors: Pei-Jiun Tsai, Chang-Ching Yeh, Wan-Jhen Huang, Ming-Yuan Min, Tzu-Hao Huang, Tsui-Ling Ko, Pei-Yu Huang, Tien-Hua Chen, Sanford P. C. Hsu, Bing-Wen Soong and Yu-Show Fu
    Citation: Translational Neurodegeneration 2019 8:29
  20. The fundamental role that alpha-synuclein (aSyn) plays in the pathogenesis of neurodegenerative synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, is a we...

    Authors: Naomi P. Visanji, Anthony E. Lang and Gabor G. Kovacs
    Citation: Translational Neurodegeneration 2019 8:28
  21. In vivo diffusion tensor imaging (DTI) of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis (ALS).

    Authors: Hans-Peter Müller, David Brenner, Francesco Roselli, Diana Wiesner, Alireza Abaei, Martin Gorges, Karin M. Danzer, Albert C. Ludolph, William Tsao, Philip C. Wong, Volker Rasche, Jochen H. Weishaupt and Jan Kassubek
    Citation: Translational Neurodegeneration 2019 8:27
  22. Alterations in the expression of human kallikrein-related peptidases (KLKs) have been described in patients with Alzheimer’s disease (AD). We elucidated the suitability of KLK6, KLK8 and KLK10 to distinguish A...

    Authors: Oliver Goldhardt, Inanna Warnhoff, Igor Yakushev, Ilijana Begcevic, Hans Förstl, Viktor Magdolen, Antoninus Soosaipillai, Eleftherios Diamandis, Panagiotis Alexopoulos and Timo Grimmer
    Citation: Translational Neurodegeneration 2019 8:25
  23. Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During the course of disease, misfolded α-syn...

    Authors: Shirley Yin-Yu Pang, Philip Wing-Lok Ho, Hui-Fang Liu, Chi-Ting Leung, Lingfei Li, Eunice Eun Seo Chang, David Boyer Ramsden and Shu-Leong Ho
    Citation: Translational Neurodegeneration 2019 8:23
  24. Parkinson’s disease (PD) is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative parkinsonisms. PD is characterized by intraneuronal accumulatio...

    Authors: Chiara Maria Giulia De Luca, Antonio Emanuele Elia, Sara Maria Portaleone, Federico Angelo Cazzaniga, Martina Rossi, Edoardo Bistaffa, Elena De Cecco, Joanna Narkiewicz, Giulia Salzano, Olga Carletta, Luigi Romito, Grazia Devigili, Paola Soliveri, Pietro Tiraboschi, Giuseppe Legname, Fabrizio Tagliavini…
    Citation: Translational Neurodegeneration 2019 8:24
  25. The number and health burden of Parkinson’s disease increase rapidly in China. It is estimated that China will have nearly half of the Parkinson’s disease population in the world in 2030. In this review, we pr...

    Authors: Gen Li, Jianfang Ma, Shishuang Cui, Yixi He, Qin Xiao, Jun Liu and Shengdi Chen
    Citation: Translational Neurodegeneration 2019 8:22
  26. Although many causative genes of hereditary spastic paraplegia (HSP) have been uncovered in recent years, there are still approximately 50% of HSP patients without genetically diagnosis, especially in autosoma...

    Authors: Qiao Wei, Hai-Lin Dong, Li-Ying Pan, Cong-Xin Chen, Yang-Tian Yan, Rou-Min Wang, Hong-Fu Li, Zhi-Jun Liu, Qing-Qing Tao and Zhi-Ying Wu
    Citation: Translational Neurodegeneration 2019 8:19
  27. Progressive accumulation of α-synuclein is a key step in the pathological development of Parkinson’s disease. Impaired protein degradation and increased levels of α-synuclein may trigger a pathological aggrega...

    Authors: Jia-Zhen Wu, Mustafa Ardah, Caroline Haikal, Alexander Svanbergsson, Meike Diepenbroek, Nishant N. Vaikath, Wen Li, Zhan-You Wang, Tiago F. Outeiro, Omar M. El-Agnaf and Jia-Yi Li
    Citation: Translational Neurodegeneration 2019 8:18
  28. Parkinson’s disease (PD), the most common neurodegenerative movement disorder, is characterized by dopaminergic nigrostriatal neuron loss and brain accumulation of Lewy bodies, protein aggregates mainly compos...

    Authors: Edoardo Parrella, Arianna Bellucci, Vanessa Porrini, Marina Benarese, Annamaria Lanzillotta, Gaia Faustini, Francesca Longhena, Giulia Abate, Daniela Uberti and Marina Pizzi
    Citation: Translational Neurodegeneration 2019 8:16
  29. Erythrocytes are a major source of peripheral α-synuclein (α-Syn). The goal of the current investigation is to evaluate erythrocytic total, oligomeric/aggregated, and phosphorylated α-Syn species as biomarkers...

    Authors: Chen Tian, Genliang Liu, Liyan Gao, David Soltys, Catherine Pan, Tessandra Stewart, Min Shi, Zhiying Xie, Na Liu, Tao Feng and Jing Zhang
    Citation: Translational Neurodegeneration 2019 8:15
  30. Few studies have investigated the effects of blood glucose (BG) on cognitive function in community-dwelling elderly individuals carrying the apolipoprotein E (APOE) ε3 allele.

    Authors: Qi Qiu, Xiang Lin, Lin Sun, Min-jie Zhu, Tao Wang, Jing-hua Wang, Guan-jun Li, Shi-fu Xiao and Xia Li
    Citation: Translational Neurodegeneration 2019 8:12
  31. IgG-class autoantibodies to N-Methyl-D-Aspartate (NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis. Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with P...

    Authors: Franziska Hopfner, Stefanie H. Müller, Dagmar Steppat, Joanna Miller, Nele Schmidt, Klaus-Peter Wandinger, Frank Leypoldt, Daniela Berg, Andre Franke, Wolfgang Lieb, Lukas Tittmann, Monika Balzer-Geldsetzer, Simon Baudrexel, Richard Dodel, Ruediger Hilker-Roggendorf, Elke Kalbe…
    Citation: Translational Neurodegeneration 2019 8:11
  32. Amyotrophic lateral sclerosis (ALS) is a late onset neurodegenerative disease with fast progression. ALS has heavy genetic components in which a series of genetic mutations have been identified. In 2013, Mutat...

    Authors: Cheng Cheng, Kan Yang, Xinwei Wu, Yuefang Zhang, Shifang Shan, Aaron Gitler, Anirvan Ghosh and Zilong Qiu
    Citation: Translational Neurodegeneration 2019 8:13
  33. The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous ...

    Authors: José Aguareles, Juan Paraíso-Luna, Belén Palomares, Raquel Bajo-Grañeras, Carmen Navarrete, Andrea Ruiz-Calvo, Daniel García-Rincón, Elena García-Taboada, Manuel Guzmán, Eduardo Muñoz and Ismael Galve-Roperh
    Citation: Translational Neurodegeneration 2019 8:9
  34. Building brain reserves before dementia onset could represent a promising strategy to prevent Alzheimer’s disease (AD), while how to initiate early cognitive stimulation is unclear. Given that the immature bra...

    Authors: Enjie Liu, Qiuzhi Zhou, Ao-Ji Xie, Mengzhu Li, Shujuan Zhang, Hezhou Huang, Zhenyu Liuyang, Yali Wang, Bingjin Liu, Xiaoguang Li, Dongsheng Sun, Yuping Wei, Xiaochuan Wang, Qun Wang, Dan Ke, Xifei Yang…
    Citation: Translational Neurodegeneration 2019 8:8
  35. Abnormal aggregation of brain α-synuclein is a central step in the pathogenesis of Parkinson’s disease (PD), thus, it is reliable to promote the clearance of α-synuclein to prevent and treat PD. Recent studies...

    Authors: Wenyan Zou, Tinglin Pu, Weixi Feng, Ming Lu, Ying Zheng, Renhong Du, Ming Xiao and Gang Hu
    Citation: Translational Neurodegeneration 2019 8:7
  36. Gastrointestinal dysfunction can affect Parkinson’s disease (PD) patients long before the onset of motor symptoms. However, little is known about the relationship between gastrointestinal abnormalities and the...

    Authors: Lucia Rota, Carolina Pellegrini, Laura Benvenuti, Luca Antonioli, Matteo Fornai, Corrado Blandizzi, Antonino Cattaneo and Emanuela Colla
    Citation: Translational Neurodegeneration 2019 8:5
  37. Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, which is characterized by the progressive loss of dopaminergic neurons in the Substantia Nigra pars compacta concomitant with Le...

    Authors: Zhi Dong Zhou, Thevapriya Selvaratnam, Ji Chao Tristan Lee, Yin Xia Chao and Eng-King Tan
    Citation: Translational Neurodegeneration 2019 8:6
  38. Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease (AD) have not been fully clarified. 5-Hydroxytryptamine transporter gene-linked polymorphic region (5-HTTLPR) is a variable number ta...

    Authors: Grazia D’Onofrio, Francesco Panza, Daniele Sancarlo, Michele Lauriola, Mariangela P. Dagostino, Giulia Paroni, Madia Lozupone, Antonio Mangiacotti, Paola Bisceglia, Carolina Gravina, Maria Urbano, Filomena Addante, Francesco Paris, Leandro Cascavilla, Antonio Greco and Davide Seripa
    Citation: Translational Neurodegeneration 2019 8:4
  39. Parkinson’s disease (PD) is characterized by a chronic loss of dopaminergic neurons and the presence of proteinaceous inclusions (Lewy bodies) within some remaining neurons in the substantia nigra. Recently, a...

    Authors: Shen-zhao Lu, Yong-shun Guo, Pei-zhou Liang, Shu-zhen Zhang, Shu Yin, Yan-qing Yin, Xiao-min Wang, Fei Ding, Xiao-song Gu and Jia-wei Zhou
    Citation: Translational Neurodegeneration 2019 8:3
  40. SOD1 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) in non-Caucasian patients. Detailed natural history profiles of SOD1-mutant patients will be beneficial for the strategy and interpr...

    Authors: Lu Tang, Yan Ma, Xiao-lu Liu, Lu Chen and Dong-sheng Fan
    Citation: Translational Neurodegeneration 2019 8:2

    The Correction to this article has been published in Translational Neurodegeneration 2019 8:10

  41. Parkinson’s Disease (PD) with mild cognitive impairment (MCI) (PD-MCI) represents one of the most dreaded complications for patients with PD and is associated with a higher risk of developing dementia. Althoug...

    Authors: Mauro Adenzato, Rosa Manenti, Ivan Enrici, Elena Gobbi, Michela Brambilla, Antonella Alberici, Maria Sofia Cotelli, Alessandro Padovani, Barbara Borroni and Maria Cotelli
    Citation: Translational Neurodegeneration 2019 8:1
  42. Alzheimer’s disease (AD) is a fatal disease that threatens the quality of life of an aging population at a global scale. Various hypotheses on the etiology of AD have been developed over the years to guide eff...

    Authors: Hongmei Li, Chia-Chen Liu, Hui Zheng and Timothy Y. Huang
    Citation: Translational Neurodegeneration 2018 7:34
  43. In the original publication of this article [1] surname of the first author is wrong.

    Authors: Dan Zheng, Wei Xia, Zhong Quan Yi, Pan Wen Zhao, Jian Guo Zhong, Hai Cun Shi, Hua Liang Li, Zhen Yu Dai and Ping Lei Pan
    Citation: Translational Neurodegeneration 2018 7:33

    The original article was published in Translational Neurodegeneration 2018 7:26

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