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  1. Content type: Review

    Alzheimer’s disease (AD) is a common neurodegenerative disease characterized clinically by progressive deterioration of memory, and pathologically by histopathological changes including extracellular deposits ...

    Authors: Suzhen Dong, Yale Duan, Yinghe Hu and Zheng Zhao

    Citation: Translational Neurodegeneration 2012 1:18

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  2. Content type: Research

    The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease (PD) is still poorly understood.

    Authors: Toni L Pitcher, Tracy R Melzer, Michael R MacAskill, Charlotte F Graham, Leslie Livingston, Ross J Keenan, Richard Watts, John C Dalrymple-Alford and Tim J Anderson

    Citation: Translational Neurodegeneration 2012 1:17

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  3. Content type: Research

    Curcumin,a natural polyphenol obtained from turmeric,has been implicated to be neuroprotective in a variety of neurodegenerative disorders although the mechanism remains poorly understood. The results of our r...

    Authors: Jing Pan, Hui Li, Jian-Fang Ma, Yu-Yan Tan, Qin Xiao, Jian-Qing Ding and Sheng-Di Chen

    Citation: Translational Neurodegeneration 2012 1:16

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  4. Content type: Research

    Neurogenesis, including the proliferation, migration and differentiation of neural progenitor cells (NPCs), is impaired in HIV-1 associated dementia (HAD). We previously demonstrated HIV-1-infected macrophages...

    Authors: Yumei Wu, Qiang Chen, Hui Peng, Huanyu Dou, You Zhou, Yunlong Huang and Jialin C Zheng

    Citation: Translational Neurodegeneration 2012 1:15

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  5. Content type: Review

    Symptomatic treatment during the dementia stage of Alzheimer’s disease(AD) cannot delay or halt the progression of this disease. Therefore, prevention in the preclinical stage is likely the most effective way ...

    Authors: Serge Gauthier, Liyong Wu, Pedro Rosa-Neto and Jianping Jia

    Citation: Translational Neurodegeneration 2012 1:13

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  6. Content type: Research

    Focal dystonia is a neurological disorder characterized by unwanted muscle spasms. Blepharospasm is a focal dystonia producing an involuntary closure of the eyelid. Its etiology is unknown.

    Authors: Silvina G Horovitz, Anastasia Ford, Muslimah Ali Najee-ullah, John L Ostuni and Mark Hallett

    Citation: Translational Neurodegeneration 2012 1:12

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  7. Content type: Review

    Parkinson`s disease (PD) is a progressive, disabling neurodegenerative disorder with onset of motor and non-motor features. Both reduce quality of life of PD patients and cause caregiver burden. This review ai...

    Authors: Thomas Müller

    Citation: Translational Neurodegeneration 2012 1:10

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  8. Content type: Research

    Amyloid-β-protein (Aβ), the key component of senile plaques in Alzheimer's disease (AD) brain, is produced from amyloid precursor protein (APP) by cleavage of β-secretase and then γ-secretase. APP adaptor prot...

    Authors: Zhongcong Xie, Yuanlin Dong, Uta Maeda, Weiming Xia and Rudolph E Tanzi

    Citation: Translational Neurodegeneration 2012 1:8

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  9. Content type: Research

    Several studies indicated that Erythropoietin (Epo) may provide remarkable neuroprotection in some neurological diseases. It also showed the significant decrease of Epo immunoreactivity in the cerebral cortex and...

    Authors: Sun Zhi-Kun, Yang Hong-Qi, Wang Zhi-Quan, Pan Jing, Hong Zhen and Chen Sheng-Di

    Citation: Translational Neurodegeneration 2012 1:7

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  10. Content type: Review

    This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson's disease (PD). Mitochondria provide cellular ener...

    Authors: Philip WL Ho, Jessica WM Ho, Hui-Fang Liu, Danny HF So, Zero HM Tse, Koon-Ho Chan, David B Ramsden and Shu-Leong Ho

    Citation: Translational Neurodegeneration 2012 1:3

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  11. Content type: Research

    The A53T mutation in the α-synuclein gene causes autosomal-dominant Lewy body Parkinson's disease (PD). Cultured cell models have linked this mutation to increased cell macroautophagy, although evidence of enhanc...

    Authors: Yue Huang, Fariba Chegini, Germaine Chua, Karen Murphy, Weiping Gai and Glenda M Halliday

    Citation: Translational Neurodegeneration 2012 1:2

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