Skip to main content

Correction to: Effectiveness and safety of opicapone in Parkinson’s disease patients with motor fluctuations: the OPTIPARK open-label study

  • The original article was published in Translational Neurodegeneration 2020 9:9

Correction to: Transl Neurodegener (2020) 9:9

https://doi.org/10.1186/s40035-020-00187-1

In this published article [1], the efficacy data for the below outcomes were unfortunately not supplied based on the Full Analysis Set (FAS) at 3 and/or 6 months for specific outcomes under the statistical analysis plan (SAP). The SAP specified that the efficacy data should be based overall on the FAS at 3 months for the primary (with last observation carried forward, LOCF) and secondary (no LOCF) efficacy endpoints and 6 months for UK only (no LOCF). The amendments do not change the conclusions of the paper, and the corrected data are given below.

Clinician and patient global impressions of change

Correction to CGI-C 6-month data (UK patients only)

[ … ] For those UK patients (n = 95) who were also assessed at 6 months, 85.3% were judged as improved since commencing treatment (8.4% very much improved and 49.5% much improved) while 8.4% were judged as showing ‘no change’ and 6.4% as having worsened. [ … ]

Correction to Fig. 2b

Fig. 2
figure1

Global Impression of Change following 3 months treatment with opicapone 50 mg (a) investigator rated (CGI-C, n = 477, LOCF); (b) self-rated by the patient (PGI-C, n = 393)

Rating scale outcomes

Correction to UPDRS analyses (Table 2)

Table 2 Rating scale assessments

N numbers for UPDRS Part II were 475 at baseline and 389 at 3 months (Visit 4); results of the change from baseline analysis remain unchanged. N numbers for UPDRS Part III were 476 at baseline and 391 at 3 months; results of the change from baseline analyses remain unchanged.

Correction to Table 2.

Levodopa dosing

Correction to levodopa dosing

After 3 months of treatment with opicapone, most patients remained on the same total daily levodopa frequency (77.1% had no change, 10.4% had an increase and 12.5% had a decrease in dosing frequency), resulting in an overall mean change of approximately − 10 mg/day. […].

Discussion

Correction to discussion

[ … ] These judgements made by the investigators were corroborated by the patients themselves.

with 48.1% patients reporting they were much or very much improved after 3 months treatment with opicapone 50 mg. [ … ]

Supplementary material

Correction to Supplementary Table 2

Results of the change from baseline in perceptual problems/hallucinations was updated to 0.0 ± 2.01. Results from all other analyses remain unchanged.

Supplementary Table 2 Change from baseline in NMSS domains

NMSS domainMean ± SD
[ … ]
Perceptual problems/hallucinations
 Baseline0.8 ± 2.45
 Change from baseline (p value)0.0 ± 2.01 (p = 0.7437)
[ … ]

Reference

  1. 1.

    Reichmann H, Lees A, Rocha JF, Magalhães D, Soares-da-Silva P, OPTIPARK investigators. Effectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations: the OPTIPARK open-label study. Transl Neurodegener. 2020;9:9. https://doi.org/10.1186/s40035-020-00187-1.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Affiliations

Authors

Consortia

Corresponding author

Correspondence to Patrício Soares-da-Silva.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Reichmann, H., Lees, A., Rocha, J. et al. Correction to: Effectiveness and safety of opicapone in Parkinson’s disease patients with motor fluctuations: the OPTIPARK open-label study. Transl Neurodegener 9, 14 (2020). https://doi.org/10.1186/s40035-020-00193-3

Download citation