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  1. Review

    The study of brain functional connectivity in Parkinson’s disease

    Parkinson’s disease (PD) is a neurodegenerative disorder primarily affecting the aging population. The neurophysiological mechanisms underlying parkinsonian symptoms remain unclear. PD affects extensive neural...

    Lin-lin Gao and Tao Wu

    Translational Neurodegeneration 2016 5:18

    Published on: 28 October 2016

  2. Review

    The biomarkers of immune dysregulation and inflammation response in Parkinson disease

    Parkinson’s disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histoco...

    Li Chen, Mingshu Mo, Guangning Li, Luan Cen, Lei Wei, Yousheng Xiao, Xiang Chen, Shaomin Li, Xinling Yang, Shaogang Qu and Pingyi Xu

    Translational Neurodegeneration 2016 5:16

    Published on: 26 August 2016

  3. Research

    The predictive value of SS-16 in clinically diagnosed Parkinson’s disease patients: comparison with 99mTc-TRODAT-1 SPECT scans

    Dopamine transporter based imaging has high diagnostic performance in distinguishing patients with Parkinson’s disease (PD) from patients with non-Parkinsonian syndromes. Our previous study indicated that the ...

    Wenyan Kang, Fangyi Dong, Dunhui Li, Thomas J. Quinn, Shengdi Chen and Jun Liu

    Translational Neurodegeneration 2016 5:15

    Published on: 20 August 2016

  4. Review

    Mitochondrial dysfunction in Parkinson’s disease

    Parkinson’s disease (PD) is the second most common neurodegenerative disease, which is characterized by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta and the formation of Lewy bodies ...

    Qingsong Hu and Guanghui Wang

    Translational Neurodegeneration 2016 5:14

    Published on: 22 July 2016

  5. Review

    The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease

    Parkinson’s disease (PD) is a chronic, progressive and debilitating disease, which affects over 2.5 million people in China. PD is characterized clinically by resting tremor, muscular rigidity, bradykinesia an...

    Shengdi Chen, Piu Chan, Shenggang Sun, Haibo Chen, Baorong Zhang, Weidong Le, Chunfeng Liu, Guoguang Peng, Beisha Tang, Lijuan Wang, Yan Cheng, Ming Shao, Zhenguo Liu, Zhenfu Wang, Xiaochun Chen, Mingwei Wang…

    Translational Neurodegeneration 2016 5:12

    Published on: 30 June 2016

  6. Review

    Meta-analysis of risk factors for Parkinson’s disease dementia

    Parkinson’s disease (PD) is a common heterogeneous neurodegenerative disorder in elder population. Parkinson’s disease dementia (PDD) is one of the most common non-motor manifestations in PD patients. No compr...

    Yaqian Xu, Jing Yang and Huifang Shang

    Translational Neurodegeneration 2016 5:11

    Published on: 1 June 2016

  7. Research

    Methylation status of DJ-1 in leukocyte DNA of Parkinson’s disease patients

    DJ-1 has been thought as a candidate biomarker for Parkinson’s disease (PD). It was found reduced in PD brains, CSF and saliva, although there were conflicting results. How DJ-1 expression may be regulated is ...

    Yuyan Tan, Li Wu, Dunhui Li, Xiaoli Liu, Jianqing Ding and Shengdi Chen

    Translational Neurodegeneration 2016 5:5

    Published on: 31 March 2016

  8. Research

    miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia – an exploratory study

    MicroRNAs (miRNAs) are small non-coding RNA molecules that function as posttranscriptional regulators of gene expression. Measurements of miRNAs in cerebrospinal fluid (CSF) and blood have just started gaining...

    Sofie Sølvsten Sørensen, Ann-Britt Nygaard and Thomas Christensen

    Translational Neurodegeneration 2016 5:6

    Published on: 15 March 2016

  9. Review

    Genotype-phenotype correlations of amyotrophic lateral sclerosis

    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive neuronal loss and degeneration of upper motor neuron (UMN) and lower motor neuron (LMN). The clinical...

    Hong-Fu Li and Zhi-Ying Wu

    Translational Neurodegeneration 2016 5:3

    Published on: 3 February 2016

  10. Short report

    Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait

    Freezing of gait (FoG) is a common and debilitating condition in Parkinson’s disease (PD) associated with executive dysfunction. A subtype of FoG does not respond to dopaminergic therapy and may be related to ...

    Gonzalo J. Revuelta, Aaron Embry, Jordan J. Elm, Chris Gregory, Amy Delambo, Steve Kautz and Vanessa K. Hinson

    Translational Neurodegeneration 2015 4:24

    Published on: 10 December 2015

  11. Research

    No apparent transmission of transgenic α–synuclein into nigrostriatal dopaminergic neurons in multiple mouse models

    α–synuclein (α–syn) is the main component of intracytoplasmic inclusions deposited in the brains of patients with Parkinson’s disease (PD) and certain other neurodegenerative disorders. Recent studies have exp...

    Namratha Sastry, Wang Zheng, Guoxiang Liu, Helen Wang, Xi Chen, Michael Cai, Parth Contractor, Carmelo Sgobio, Lixin Sun, Chengsong Xie and Huaibin Cai

    Translational Neurodegeneration 2015 4:23

    Published on: 3 December 2015

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