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Translational Neurodegeneration

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  1. Content type: Research

    Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a new candidate growth factor for dopaminergic neurons against endoplasmic reticulum stress (ER stress). HSP70 family, a chaperon like heat shock p...

    Authors: Hui Sun, Ming Jiang, Xing Fu, Qiong Cai, Jingxing Zhang, Yanxin Yin, Jia Guo, Lihua Yu, Yun Jiang, Yigang Liu, Liang Feng, Zhiyu Nie, Jianmin Fang and Lingjing Jin

    Citation: Translational Neurodegeneration 2017 6:12

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  2. Content type: Review

    Some studies have shown that low frequency stimulation (LFS, most commonly 60 Hz), compared to high frequency stimulation (HFS, most commonly 130 Hz), has beneficial effects, short-term or even long-term, on i...

    Authors: Tao Xie, Mahesh Padmanaban, Lisa Bloom, Ellen MacCracken, Breanna Bertacchi, Abraham Dachman and Peter Warnke

    Citation: Translational Neurodegeneration 2017 6:13

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  3. Content type: Research

    Recent studies have found that the functional catechol-O-methyltransferase (COMT) gene may be associated with the susceptibility to and pharmacotherapy of Parkinson’s disease (PD). In this case–control study, ...

    Authors: Yiwei Qian, Jiujiang Liu, Shaoqing Xu, Xiaodong Yang and Qin Xiao

    Citation: Translational Neurodegeneration 2017 6:11

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  4. Content type: Research

    Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis, which converts glutamine into glutamate. Glutamate is the major neurotransmitter of excitatory synapses,...

    Authors: Yuju Li, Justin Peer, Runze Zhao, Yinghua Xu, Beiqing Wu, Yi Wang, Changhai Tian, Yunlong Huang and Jialin Zheng

    Citation: Translational Neurodegeneration 2017 6:10

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  5. Content type: Review

    Two centuries ago in 1817, James Parkinson provided the first medical description of Parkinson’s disease, later refined by Jean-Martin Charcot in the mid-to-late 19th century to include the atypical parkinsoni...

    Authors: Usman Saeed, Jordana Compagnone, Richard I. Aviv, Antonio P. Strafella, Sandra E. Black, Anthony E. Lang and Mario Masellis

    Citation: Translational Neurodegeneration 2017 6:8

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  6. Content type: Review

    A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse. Therapeutic options are currently...

    Authors: Patrick Sweeney, Hyunsun Park, Marc Baumann, John Dunlop, Judith Frydman, Ron Kopito, Alexander McCampbell, Gabrielle Leblanc, Anjli Venkateswaran, Antti Nurmi and Robert Hodgson

    Citation: Translational Neurodegeneration 2017 6:6

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  7. Content type: Research

    It is increasingly clear that in addition to myelin disruption, axonal degeneration may also represent a key pathology in multiple sclerosis (MS). Hence, elucidating the mechanisms of axonal degeneration may n...

    Authors: Gary Leung, Melissa Tully, Jonathan Tang, Shengxi Wu and Riyi Shi

    Citation: Translational Neurodegeneration 2017 6:5

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  8. Content type: Review

    Neurodegeneration of Parkinson’s disease (PD) starts in an insidious manner, 30–50% of dopaminergic neurons have been lost in the substantia nigra before clinical diagnosis. Prodromal stage of the disease, dur...

    Authors: Shu-Ying Liu, Piu Chan and A. Jon Stoessl

    Citation: Translational Neurodegeneration 2017 6:4

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  9. Content type: Review

    Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular componen...

    Authors: Tingting Xiao, Weiwei Zhang, Bin Jiao, Chu-Zheng Pan, Xixi Liu and Lu Shen

    Citation: Translational Neurodegeneration 2017 6:3

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  10. Content type: Review

    Alzheimer’s Disease (AD) is a global health issue given the increasing prevalence rate and the limitations of drug effects. As a consequent, non-pharmacological interventions are of importance. Music therapy (...

    Authors: Rong Fang, Shengxuan Ye, Jiangtao Huangfu and David P. Calimag

    Citation: Translational Neurodegeneration 2017 6:2

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  11. Content type: Review

    L-3, 4-Dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) is a major clinical complication in the treatment of Parkinson’s disease (PD). This debilitating side effect likely reflects aberrant compensator...

    Authors: Jing Pan and Huaibin Cai

    Citation: Translational Neurodegeneration 2017 6:1

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  12. Content type: Case report

    Acute-onset neurodegenerative diseases in older patients are rare clinical cases, especially when the degeneration only affects specific regions of the nervous system. Several neurological disorders have been ...

    Authors: Alexander Schulz, Franziska Wagner, Martin Ungelenk, Ingo Kurth and Christoph Redecker

    Citation: Translational Neurodegeneration 2016 5:23

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  13. Content type: Research

    Diabetes is the most common metabolic disease with many chronic complications, and cognitive disorders are one of the common complications in patients with diabetes. Previous studies have showed that autophagy...

    Authors: Zhu-Fei Guan, Xiu-Ling Zhou, Xiao-Ming Zhang, Yu Zhang, Yan-Mei Wang, Qi-Lin Guo, Gang Ji, Guo-Feng Wu, Na-Na Wang, Hao Yang, Zhong-Yu Yu, Hou-Guang Zhou, Jing-Chun Guo and Ying-Chao Liu

    Citation: Translational Neurodegeneration 2016 5:22

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  14. Content type: Research

    Alzheimer’s disease (AD) is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe treatment ag...

    Authors: Bei Zhang, Qiongqiong Li, Xingkun Chu, Suya Sun and Shengdi Chen

    Citation: Translational Neurodegeneration 2016 5:21

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  15. Content type: Review

    Amyloid plaques are pathological hallmarks of Alzheimer’s Disease (AD) and biomarkers such as cerebrospinal fluid (CSF) β-amyloid 1–42 (Aβ1-42) and amyloid positron emission tomographic (PET) imaging are impor...

    Authors: Maowen Ba, Min Kong, Xiaofeng Li, Kok Pin Ng, Pedro Rosa-Neto and Serge Gauthier

    Citation: Translational Neurodegeneration 2016 5:20

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  16. Content type: Review

    Parkinson’s disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histoco...

    Authors: Li Chen, Mingshu Mo, Guangning Li, Luan Cen, Lei Wei, Yousheng Xiao, Xiang Chen, Shaomin Li, Xinling Yang, Shaogang Qu and Pingyi Xu

    Citation: Translational Neurodegeneration 2016 5:16

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  17. Content type: Research

    Dopamine transporter based imaging has high diagnostic performance in distinguishing patients with Parkinson’s disease (PD) from patients with non-Parkinsonian syndromes. Our previous study indicated that the ...

    Authors: Wenyan Kang, Fangyi Dong, Dunhui Li, Thomas J. Quinn, Shengdi Chen and Jun Liu

    Citation: Translational Neurodegeneration 2016 5:15

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  18. Content type: Review

    Parkinson’s disease (PD) is the second most common neurodegenerative disease, which is characterized by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta and the formation of Lewy bodies ...

    Authors: Qingsong Hu and Guanghui Wang

    Citation: Translational Neurodegeneration 2016 5:14

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  19. Content type: Review

    Parkinson’s disease (PD) is a chronic, progressive and debilitating disease, which affects over 2.5 million people in China. PD is characterized clinically by resting tremor, muscular rigidity, bradykinesia an...

    Authors: Shengdi Chen, Piu Chan, Shenggang Sun, Haibo Chen, Baorong Zhang, Weidong Le, Chunfeng Liu, Guoguang Peng, Beisha Tang, Lijuan Wang, Yan Cheng, Ming Shao, Zhenguo Liu, Zhenfu Wang, Xiaochun Chen, Mingwei Wang…

    Citation: Translational Neurodegeneration 2016 5:12

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