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  1. TDP-43 proteinopathies represent a spectrum of neurological disorders, anchored clinically on either end by amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). The ALS–FTD spectrum exhib...

    Authors: Ting Shen, Jacob W. Vogel, Jeffrey Duda, Jeffrey S. Phillips, Philip A. Cook, James Gee, Lauren Elman, Colin Quinn, Defne A. Amado, Michael Baer, Lauren Massimo, Murray Grossman, David J. Irwin and Corey T. McMillan
    Citation: Translational Neurodegeneration 2023 12:57
    Content type: Research Published on:

  2. Cognitive decline in Alzheimer’s disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV b...

    Authors: Carolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R. Joe, Rana Rais, Norman J. Haughey, Dimitrios Kapogiannis…
    Citation: Translational Neurodegeneration 2023 12:56
    Content type: Research Published on:

  3. Deep brain stimulation (DBS) is a well-established and effective treatment for patients with advanced Parkinson's disease (PD), yet its underlying mechanisms remain enigmatic. Optogenetics, primarily conducted...

    Authors: Wenying Xu, Jie Wang, Xin-Ni Li, Jingxue Liang, Lu Song, Yi Wu, Zhenguo Liu, Bomin Sun and Wei-Guang Li
    Citation: Translational Neurodegeneration 2023 12:55
    Content type: Review Published on:

  4. Synaptic degeneration occurs in the early stage of Alzheimer's disease (AD) before devastating symptoms, strongly correlated with cognitive decline. Circular RNAs (circRNAs) are abundantly enriched in neural t...

    Authors: Xiong Wang, Jiazhao Xie, Lu Tan, Yanjun Lu, Na Shen, Jiaoyuan Li, Hui Hu, Huijun Li, Xiaoguang Li and Liming Cheng
    Citation: Translational Neurodegeneration 2023 12:53
    Content type: Research Published on:

  5. ClinicalTrials.gov Identifier: NCT05821153, Registered April 20 2023, Retrospectively registered, https://​classic.​clinicaltrials.​gov/​ct2/​show/​NCT05821153

    Authors: Alireza Faridar, Abdulmunaim M. Eid, Aaron D. Thome, Weihua Zhao, David R. Beers, Maria B. Pascual, Mohammad O. Nakawah, Gustavo C. Roman, Charles S. Davis, Michael Grundman, Joseph C. Masdeu and Stanley H. Appel
    Citation: Translational Neurodegeneration 2023 12:54
    Content type: Letter Published on:

  6. Oligodendrocyte progenitor cells (OPCs) play pivotal roles in myelin formation and phagocytosis, communicating with neighboring cells and contributing to the integrity of the blood–brain barrier (BBB). However...

    Authors: Peibin Zou, Chongyun Wu, Timon Cheng-Yi Liu, Rui Duan and Luodan Yang
    Citation: Translational Neurodegeneration 2023 12:52
    Content type: Review Published on:

  7. Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark of Alzheimer’s disease (AD). However, mouse models imitating AD-exclusive neuronal tau pathologies are lacking.

    Authors: Yang Gao, Yuying Wang, Huiyang Lei, Zhendong Xu, Shihong Li, Haitao Yu, Jiazhao Xie, Zhentao Zhang, Gongping Liu, Yao Zhang, Jie Zheng and Jian-Zhi Wang
    Citation: Translational Neurodegeneration 2023 12:51
    Content type: Research Published on:

    The Correction to this article has been published in Translational Neurodegeneration 2024 13:5

  8. Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly, resulting in gradual destruction of cognitive abilities. Research on the development of various AD treatments is underway;...

    Authors: Hyunkyung Mo, Juryun Kim, Jennifer Yejean Kim, Jang Woon Kim, Heeju Han, Si Hwa Choi, Yeri Alice Rim and Ji Hyeon Ju
    Citation: Translational Neurodegeneration 2023 12:50
    Content type: Research Published on:

  9. Cognitive impairment is a multifactorial and multi-step pathological process that places a heavy burden on patients and the society. Neuroinflammation is one of the main factors leading to cognitive impairment...

    Authors: Yi Xu, Yanling Yang, Xi Chen, Danling Jiang, Fei Zhang, Yao Guo, Bin Hu, Guohai Xu, Shengliang Peng, Lidong Wu and Jialing Hu
    Citation: Translational Neurodegeneration 2023 12:49
    Content type: Review Published on:

  10. Microglia, the resident immune cells of the brain, are increasingly implicated in the regulation of brain health and disease. Microglia perform multiple functions in the central nervous system, including surve...

    Authors: Izabela Lepiarz-Raba, Ismail Gbadamosi, Roberta Florea, Rosa Chiara Paolicelli and Ali Jawaid
    Citation: Translational Neurodegeneration 2023 12:48
    Content type: Review Published on:

  11. Amyotrophic lateral sclerosis (ALS) is a poorly treated multifactorial neurodegenerative disease associated with multiple cell types and subcellular organelles. As with other multifactorial diseases, it is lik...

    Authors: Peter J. Richardson, Daniel P. Smith, Alex de Giorgio, Xenia Snetkov, Joshua Almond-Thynne, Sara Cronin, Richard J. Mead, Christopher J. McDermott and Pamela J. Shaw
    Citation: Translational Neurodegeneration 2023 12:47
    Content type: Review Published on:

  12. In order to dissect amyotrophic lateral sclerosis (ALS), a multigenic, multifactorial, and progressive neurodegenerative disease with heterogeneous clinical presentations, researchers have generated numerous a...

    Authors: Longhong Zhu, Shihua Li, Xiao-Jiang Li and Peng Yin
    Citation: Translational Neurodegeneration 2023 12:46
    Content type: Review Published on:

  13. Friedreich ataxia (FRDA) is a rare genetic multisystem disorder caused by a pathological GAA trinucleotide repeat expansion in the FXN gene. The numerous drawbacks of historical cellular and rodent models of FRDA...

    Authors: Saumya Maheshwari, Gabriela Vilema-Enríquez and Richard Wade-Martins
    Citation: Translational Neurodegeneration 2023 12:45
    Content type: Review Published on:

  14. A pathological feature of Parkinson’s disease (PD) is the progressive loss of dopaminergic neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD brains. DA is the neurotransmi...

    Authors: Zhi Dong Zhou, Ling Xiao Yi, Dennis Qing Wang, Tit Meng Lim and Eng King Tan
    Citation: Translational Neurodegeneration 2023 12:44
    Content type: Review Published on:

  15. Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease, affect millions of people worldwide. Tremendous efforts have been put into...

    Authors: Zhengzhe Li, Xiaoling Wang, Xiaoxing Wang, Xiaomei Yi, Yin Kwan Wong, Jiyang Wu, Fangfang Xie, Die Hu, Qi Wang, Jigang Wang and Tianyu Zhong
    Citation: Translational Neurodegeneration 2023 12:43
    Content type: Review Published on:

  16. There is a need for biomarkers to support an accurate diagnosis of Parkinson’s disease (PD). Cerebrospinal fluid (CSF) has been a successful biofluid for finding neurodegenerative biomarkers, and modern highly...

    Authors: Wojciech Paslawski, Shervin Khosousi, Ellen Hertz, Ioanna Markaki, Adam Boxer and Per Svenningsson
    Citation: Translational Neurodegeneration 2023 12:42
    Content type: Research Published on:

  18. The accumulation of α-synuclein (α-syn), an essential step in PD development and progression, is observed not only in neurons but also in glia, including astrocytes. The mechanisms regulating astrocytic α-syn ...

    Authors: Pan Wang, Guoyu Lan, Bin Xu, Zhenwei Yu, Chen Tian, Xia Lei, Wassilios G. Meissner, Tao Feng, Ying Yang and Jing Zhang
    Citation: Translational Neurodegeneration 2023 12:40
    Content type: Research Published on:

  20. Multiple system atrophy (MSA) is a fatal progressive neurodegenerative disease. Biomarkers are urgently required for MSA to improve the diagnostic and prognostic accuracy in clinic and facilitate the developme...

    Authors: Linlin Wan, Sudan Zhu, Zhao Chen, Rong Qiu, Beisha Tang and Hong Jiang
    Citation: Translational Neurodegeneration 2023 12:38
    Content type: Review Published on:

  21. A wealth of pre-clinical reports and data derived from human subjects and brain autopsies suggest that microbial infections are relevant to Alzheimer’s disease (AD). This has inspired the hypothesis that micro...

    Authors: Celso S. G. Catumbela, Vijayasree V. Giridharan, Tatiana Barichello and Rodrigo Morales
    Citation: Translational Neurodegeneration 2023 12:37
    Content type: Review Published on:

  22. Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. More than 200 years after its first clinical description, PD remains a serious affliction tha...

    Authors: Axelle Dovonou, Cyril Bolduc, Victoria Soto Linan, Charles Gora, Modesto R. Peralta III and Martin Lévesque
    Citation: Translational Neurodegeneration 2023 12:36
    Content type: Review Published on:

  23. The current diagnosis of Alzheimer’s disease (AD) is based on a series of analyses which involve clinical, instrumental and laboratory findings. However, signs, symptoms and biomarker alterations observed in A...

    Authors: Cristiano D’Andrea, Federico Angelo Cazzaniga, Edoardo Bistaffa, Andrea Barucci, Marella de Angelis, Martina Banchelli, Edoardo Farnesi, Panagis Polykretis, Chiara Marzi, Antonio Indaco, Pietro Tiraboschi, Giorgio Giaccone, Paolo Matteini and Fabio Moda
    Citation: Translational Neurodegeneration 2023 12:35
    Content type: Research Published on:

  24. Gaining more information about the reciprocal associations between different biomarkers within the ATN (Amyloid/Tau/Neurodegeneration) framework across the Alzheimer’s disease (AD) spectrum is clinically relev...

    Authors: Jiaying Lu, Xiaoxi Ma, Huiwei Zhang, Zhenxu Xiao, Ming Li, Jie Wu, Zizhao Ju, Li Chen, Li Zheng, Jingjie Ge, Xiaoniu Liang, Weiqi Bao, Ping Wu, Ding Ding, Tzu-Chen Yen, Yihui Guan…
    Citation: Translational Neurodegeneration 2023 12:34
    Content type: Research Published on:

  26. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. The pathogenesis of ALS remains largely unknown; however...

    Authors: Hiroshi Nango, Komugi Tsuruta, Hiroko Miyagishi, Yuri Aono, Tadashi Saigusa and Yasuhiro Kosuge
    Citation: Translational Neurodegeneration 2023 12:32
    Content type: Review Published on:

  27. Lysosomal dysfunction has been implicated in a number of neurodegenerative diseases such as Parkinson’s disease (PD). Various molecular, clinical and genetic studies have highlighted a central role of lysosoma...

    Authors: Alice Drobny, Fanni Annamária Boros, Denise Balta, Susy Prieto Huarcaya, Deniz Caylioglu, Niyeti Qazi, Julia Vandrey, Yanni Schneider, Jan Philipp Dobert, Caleb Pitcairn, Joseph Robert Mazzulli and Friederike Zunke
    Citation: Translational Neurodegeneration 2023 12:31
    Content type: Research Published on:

  28. Lysosomal acidification dysfunction has been implicated as a key driving factor in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Multiple genetic factor...

    Authors: Chih Hung Lo and Jialiu Zeng
    Citation: Translational Neurodegeneration 2023 12:29
    Content type: Review Published on:

  30. The isolated rapid-eye-movement sleep behavior disorder (iRBD) is a prodromal condition of Lewy body disease including Parkinson's disease and dementia with Lewy bodies (DLB). We aim to investigate the longitu...

    Authors: Jung Hwan Shin, Heejung Kim, Yu Kyeong Kim, Eun Jin Yoon, Hyunwoo Nam, Beomseok Jeon and Jee-Young Lee
    Citation: Translational Neurodegeneration 2023 12:27
    Content type: Research Published on:

  31. The clinical utility and safety of sargramostim has previously been reported in cancer, acute radiation syndrome, autoimmune disease, inflammatory conditions, and Alzheimer’s disease. The safety, tolerability,...

    Authors: Katherine E. Olson, Mai M. Abdelmoaty, Krista L. Namminga, Yaman Lu, Helen Obaro, Pamela Santamaria, R. Lee Mosley and Howard E. Gendelman
    Citation: Translational Neurodegeneration 2023 12:26
    Content type: Research Published on:

  34. Authors: Kelsie M. LaBarbera, Yvette I. Sheline, Nicholas J. Izzo, Carla M. Yuede, Lora Waybright, Raymond Yurko, Hannah M. Edwards, Woodrow D. Gardiner, Kaj Blennow, Henrik Zetterberg, Anne Börjesson-Hanson, Roger Morgan, Charles S. Davis, Robert J. Guttendorf, Lon S. Schneider, Steven DeKosky…
    Citation: Translational Neurodegeneration 2023 12:24
    Content type: Letter Published on:

  36. Authors: Xavier Sánchez‑Sáez, Isabel Ortuño‑Lizarán, Carla Sánchez‑Castillo, Pedro Lax and Nicolás Cuenca
    Citation: Translational Neurodegeneration 2023 12:22
    Content type: Correction Published on:

    The original article was published in Translational Neurodegeneration 2023 12:17

  37. Authors: Nuole Zhu, Miguel Santos-Santos, Ignacio Illán-Gala, Victor Montal, Teresa Estellés, Isabel Barroeta, Miren Altuna, Javier Arranz, Laia Muñoz, Olivia Belbin, Isabel Sala, Maria Belén Sánchez-Saudinós, Andrea Subirana, Laura Videla, Jordi Pegueroles, Rafael Blesa…
    Citation: Translational Neurodegeneration 2023 12:21
    Content type: Correction Published on:

    The original article was published in Translational Neurodegeneration 2021 10:50

  38. The inter-neuronal communication occurring in extensively branched neuronal cells is achieved primarily through the microtubule (MT)-mediated axonal transport system. This mechanistically regulated system deli...

    Authors: Padmashri Naren, Khan Sabiya Samim, Kamatham Pushpa Tryphena, Lalitkumar K. Vora, Saurabh Srivastava, Shashi Bala Singh and Dharmendra Kumar Khatri
    Citation: Translational Neurodegeneration 2023 12:20
    Content type: Review Published on:

  40. Redox homeostasis refers to the balance between the production of reactive oxygen species (ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is linked to all important ...

    Authors: Sina Shadfar, Sonam Parakh, Md Shafi Jamali and Julie D. Atkin
    Citation: Translational Neurodegeneration 2023 12:18
    Content type: Review Published on:

  41. The main clinical symptoms characteristic of Parkinson’s disease (PD) are bradykinesia, tremor, and other motor deficits. However, non-motor symptoms, such as visual disturbances, can be identified at early st...

    Authors: Xavier Sánchez-Sáez, Isabel Ortuño-Lizarán, Carla Sánchez-Castillo, Pedro Lax and Nicolás Cuenca
    Citation: Translational Neurodegeneration 2023 12:17
    Content type: Research Published on:

    The Correction to this article has been published in Translational Neurodegeneration 2023 12:22

  42. Neuropathological diagnosis of argyrophilic grain disease (AGD) is currently based primarily on the combination of argyrophilic grain (AG) visualized using Gallyas–Braak silver staining, phosphorylated tau-pos...

    Authors: Koji Yoshida, Yukiko Hata, Shojiro Ichimata, Keitaro Okada and Naoki Nishida
    Citation: Translational Neurodegeneration 2023 12:16
    Content type: Research Published on:

  43. In stressful or anxiety-provoking situations, most people with Parkinson’s disease (PD) experience a general worsening of motor symptoms, including their gait impairments. However, a proportion of patients act...

    Authors: Anouk Tosserams, Bastiaan R. Bloem, Kaylena A. Ehgoetz Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis and Jorik Nonnekes
    Citation: Translational Neurodegeneration 2023 12:15
    Content type: Review Published on:

  44. Authors: Hash Brown Taha, Simon Hornung, Suman Dutta, Leony Fenwick, Otmane Lahgui, Kathryn Howe, Nour Elabed, Irish del Rosario, Darice Y. Wong, Aline Duarte Folle, Daniela Markovic, Jose-Alberto Palma, Un Jung Kang, Roy N. Alcalay, Miriam Sklerov, Horacio Kaufmann…
    Citation: Translational Neurodegeneration 2023 12:14
    Content type: Letter Published on:

  45. Nasal swabs are non-invasive testing methods for detecting diseases by collecting samples from the nasal cavity or nasopharynx. Dysosmia is regarded as an early sign of coronavirus disease 2019 (COVID-19), and...

    Authors: Suying Duan, Jing Yang, Zheqing Cui, Jiaqi Li, Honglin Zheng, Taiqi Zhao, Yanpeng Yuan, Yutao Liu, Lu Zhao, Yangyang Wang, Haiyang Luo and Yuming Xu
    Citation: Translational Neurodegeneration 2023 12:13
    Content type: Review Published on:

  46. α-Synucleinopathies, such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, are a class of neurodegenerative diseases exhibiting intracellular inclusions of misfolded α-...

    Authors: Matthias Schmitz, Niccolò Candelise, Sezgi Canaslan, Hermann C. Altmeppen, Jakob Matschke, Markus Glatzel, Neelam Younas, Saima Zafar, Peter Hermann and Inga Zerr
    Citation: Translational Neurodegeneration 2023 12:12
    Content type: Review Published on:

  47. Treatment for Alzheimer’s disease (AD) can be more effective in the early stages. Although we do not completely understand the aetiology of the early stages of AD, potential pathological factors (amyloid beta ...

    Authors: Sarawoot Somin, Don Kulasiri and Sandhya Samarasinghe
    Citation: Translational Neurodegeneration 2023 12:11
    Content type: Review Published on:

  48. Persistent inflammatory response in the brain can lead to tissue damage and neurodegeneration. In Alzheimer's disease (AD), there is an aberrant activation of inflammasomes, molecular platforms that drive infl...

    Authors: Cristina de Dios, Xenia Abadin, Vicente Roca-Agujetas, Marina Jimenez-Martinez, Albert Morales, Ramon Trullas, Montserrat Mari and Anna Colell
    Citation: Translational Neurodegeneration 2023 12:10
    Content type: Research Published on:

  49. Physical exercise is of great significance for maintaining human health. Exercise can provide varying degrees of benefits to cognitive function at all stages of life cycle. Currently, with the aging of the wor...

    Authors: Yi Lu, Fa-Qian Bu, Fang Wang, Li Liu, Shuai Zhang, Guan Wang and Xiu-Ying Hu
    Citation: Translational Neurodegeneration 2023 12:9
    Content type: Review Published on:

  50. Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions of...

    Authors: Yun Shen, Qian-kun Lv, Wei-ye Xie, Si-yi Gong, Sheng Zhuang, Jun-yi Liu, Cheng-jie Mao and Chun-feng Liu
    Citation: Translational Neurodegeneration 2023 12:8
    Content type: Review Published on:
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Translational Neurodegeneration

ISSN: 2047-9158

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