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  1. Content type: Review

    Brain 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been utilized to monitor disease conversion from amnestic mild cognitive impairment (aMCI) to Alzheimer’s dementia (AD). However, the conver...

    Authors: Hai Rong Ma, Li Qin Sheng, Ping Lei Pan, Gen Di Wang, Rong Luo, Hai Cun Shi, Zhen Yu Dai and Jian Guo Zhong

    Citation: Translational Neurodegeneration 2018 7:9

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  2. Content type: Review

    Parkinson’s disease (PD) is often accompanied by clinically identified depression. Providing effective pharmacotherapies that concomitantly treat both motor and psychological symptoms can pose a challenge to p...

    Authors: Alexandra M. Lesenskyj, Megan P. Samples, Jill M. Farmer and Christina R. Maxwell

    Citation: Translational Neurodegeneration 2018 7:8

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  3. Content type: Review

    Animal models of exercise and Parkinson’s disease (PD) have found that the physiologic use of exercise may interact with the neurodegenerative disease process, likely mediated by brain derived neurotrophic fac...

    Authors: Mark A. Hirsch, Erwin E. H. van Wegen, Mark A. Newman and Patricia C. Heyn

    Citation: Translational Neurodegeneration 2018 7:7

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  4. Content type: Short report

    Tauopathies comprise a family of neurodegenerative disorders including Alzheimer’s disease for which there is an urgent and unmet need for disease-modifying treatments. Tauopathies are characterized by patholo...

    Authors: Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J. Weiss, Yitzhak Tor, Jeffrey D. Esko and Nadia Soussi-Yanicostas

    Citation: Translational Neurodegeneration 2018 7:6

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  5. Content type: Review

    Nearly 30% of adults 40 years and older in the United States are on a statin. Their widespread use heightens the importance of careful consideration of their varied effects on the body. Although randomized con...

    Authors: Bob G. Schultz, Denise K. Patten and Daniel J. Berlau

    Citation: Translational Neurodegeneration 2018 7:5

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  6. Content type: Review

    Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly est...

    Authors: Belal Shohayeb, Mohamed Diab, Mazen Ahmed and Dominic Chi Hiung Ng

    Citation: Translational Neurodegeneration 2018 7:4

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  7. Content type: Review

    Hydrogen Sulfide (H2S) and Nitric Oxide (NO) have become recognized as important gaseous signaling molecules with enormous pharmacological effects, therapeutic value, and central physiological roles. NO is one of...

    Authors: Sandesh Panthi, Sumeet Manandhar and Kripa Gautam

    Citation: Translational Neurodegeneration 2018 7:3

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  8. Content type: Review

    Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extr...

    Authors: Xiaoguang Du, Xinyi Wang and Meiyu Geng

    Citation: Translational Neurodegeneration 2018 7:2

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  9. Content type: Research

    Rapid eye movement sleep behavior disorder (RBD) and Parkinson’s disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. This study aims to confi...

    Authors: Ye Liu, Xiao-Ying Zhu, Xiao-Jin Zhang, Sheng-Han Kuo, William G. Ondo and Yun-Cheng Wu

    Citation: Translational Neurodegeneration 2017 6:35

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  10. Content type: Review

    In this mini-review, we summarize recent findings relating to the prion-like propagation of α-synuclein (α-syn) and the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s dise...

    Authors: Daniel Kam Yin Chan, Ying Hua Xu, Luke Kar Man Chan, Nady Braidy and George D. Mellick

    Citation: Translational Neurodegeneration 2017 6:33

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  11. Content type: Research

    PINK1 (PTEN-induced putative kinase 1) gene is the causal gene for recessive familial type 6 of Parkinson’s disease (PARK6), which is an early-onset autosomal recessive inherited neurodegenerative disease. PIN...

    Authors: Ji-feng Guo, Ling-yan Yao, Qi-ying Sun, Yi-ting Cui, Yang Yang, Qian Xu, Xin-xiang Yan and Bei-sha Tang

    Citation: Translational Neurodegeneration 2017 6:34

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  12. Content type: Review

    Huntington’s Disease (HD) is a genetically dominant trinucleotide repeat disorder resulting from CAG repeats within the Huntingtin (HTT) gene exceeding a normal range (> 36 CAGs). Symptoms of the disease manif...

    Authors: Sebastian Aguiar, Bram van der Gaag and Francesco Albert Bosco Cortese

    Citation: Translational Neurodegeneration 2017 6:30

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  13. Content type: Research

    Tau vaccination and administration of anti-tau antibodies can prevent pathology and cognitive impairment in transgenic mouse models of tauopathy, suggesting that therapies which increase anti-tau antibodies mi...

    Authors: Andrea C. Klaver, Mary P. Coffey, David A. Bennett and David A. Loeffler

    Citation: Translational Neurodegeneration 2017 6:32

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  14. Content type: Research

    Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron disorders. Effective therapeutic strategies are an unmet need for these disorders....

    Authors: Rafael Lazo-Gomez and Ricardo Tapia

    Citation: Translational Neurodegeneration 2017 6:31

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  15. Content type: Research

    Extensive loss of donor neural stem cell (NSCs) due to ischemic stress and low rate of differentiation at the site of cell graft are two of the major issues that hamper optimal outcome in NSCs transplantation ...

    Authors: Parisa Tabeshmehr, Haider Kh Husnain, Mahin Salmannejad, Mahsa Sani, Seyed Mojtaba Hosseini and Mohammad Hossein Khorraminejad Shirazi

    Citation: Translational Neurodegeneration 2017 6:29

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  16. Content type: Review

    Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkins...

    Authors: Panchanan Maiti, Jayeeta Manna and Gary L. Dunbar

    Citation: Translational Neurodegeneration 2017 6:28

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  17. Content type: Review

    The clinical diagnosis of neurodegenerative disorders based on phenotype is difficult in heterogeneous conditions with overlapping symptoms. It does not take into account the disease etiology or the highly var...

    Authors: Shirley Yin-Yu Pang, Kay-Cheong Teo, Jacob Shujui Hsu, Richard Shek-Kwan Chang, Miaoxin Li, Pak-Chung Sham and Shu-Leong Ho

    Citation: Translational Neurodegeneration 2017 6:27

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  18. Content type: Review

    Photophobia is a common symptom seen in many neurologic disorders, however, its pathophysiology remains unclear. Even the term is ambiguous. In this paper, we review the epidemiology and clinical manifestation...

    Authors: Yiwen Wu and Mark Hallett

    Citation: Translational Neurodegeneration 2017 6:26

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  19. Content type: Review

    Alzheimer’s disease (AD) is the most common age-dependent disease of dementia, and there is currently no cure available. This hallmark pathologies of AD are the presence of amyloid plaques and neurofibrillary ...

    Authors: Brati Das and Riqiang Yan

    Citation: Translational Neurodegeneration 2017 6:23

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  20. Content type: Review

    Traumatic brain injury is among the most common causes of death and disability in youth and young adults. In addition to the acute risk of morbidity with moderate to severe injuries, traumatic brain injury is ...

    Authors: Marcela Cruz-Haces, Jonathan Tang, Glen Acosta, Joseph Fernandez and Riyi Shi

    Citation: Translational Neurodegeneration 2017 6:20

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  21. Content type: Review

    Alzheimer’s disease (AD) is a chronic neurodegenerative disease, which is associated with learning and memory impairment in the elderly. Recent studies have found that treating AD in the way of chromatin remod...

    Authors: Shuang-shuang Yang, Rui Zhang, Gang Wang and Yong-fang Zhang

    Citation: Translational Neurodegeneration 2017 6:19

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  22. Content type: Research

    There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease (PD-MCI) and the coping strategies used by these caregivers.

    Authors: Ann J. Jones, Roeline G. Kuijer, Leslie Livingston, Daniel Myall, Kyla Horne, Michael MacAskill, Toni Pitcher, Paul T. Barrett, Tim J. Anderson and John C. Dalrymple-Alford

    Citation: Translational Neurodegeneration 2017 6:17

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  23. Content type: Review

    Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. Since distinct diseases can cause similar tremor manifestations and vice-versa, it is...

    Authors: Wei Chen, Franziska Hopfner, Jos Steffen Becktepe and Günther Deuschl

    Citation: Translational Neurodegeneration 2017 6:16

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  24. Content type: Research

    Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for Parkinson’s disease (PD), the predictive effect of levodopa responsiveness on surgical outcomes was confirmed by some studies,...

    Authors: Xin-Ling Su, Xiao-Guang Luo, Hong Lv, Jun Wang, Yan Ren and Zhi-Yi He

    Citation: Translational Neurodegeneration 2017 6:14

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  25. Content type: Research

    Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a new candidate growth factor for dopaminergic neurons against endoplasmic reticulum stress (ER stress). HSP70 family, a chaperon like heat shock p...

    Authors: Hui Sun, Ming Jiang, Xing Fu, Qiong Cai, Jingxing Zhang, Yanxin Yin, Jia Guo, Lihua Yu, Yun Jiang, Yigang Liu, Liang Feng, Zhiyu Nie, Jianmin Fang and Lingjing Jin

    Citation: Translational Neurodegeneration 2017 6:12

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  26. Content type: Review

    Some studies have shown that low frequency stimulation (LFS, most commonly 60 Hz), compared to high frequency stimulation (HFS, most commonly 130 Hz), has beneficial effects, short-term or even long-term, on i...

    Authors: Tao Xie, Mahesh Padmanaban, Lisa Bloom, Ellen MacCracken, Breanna Bertacchi, Abraham Dachman and Peter Warnke

    Citation: Translational Neurodegeneration 2017 6:13

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  27. Content type: Research

    Recent studies have found that the functional catechol-O-methyltransferase (COMT) gene may be associated with the susceptibility to and pharmacotherapy of Parkinson’s disease (PD). In this case–control study, ...

    Authors: Yiwei Qian, Jiujiang Liu, Shaoqing Xu, Xiaodong Yang and Qin Xiao

    Citation: Translational Neurodegeneration 2017 6:11

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  28. Content type: Research

    Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis, which converts glutamine into glutamate. Glutamate is the major neurotransmitter of excitatory synapses,...

    Authors: Yuju Li, Justin Peer, Runze Zhao, Yinghua Xu, Beiqing Wu, Yi Wang, Changhai Tian, Yunlong Huang and Jialin Zheng

    Citation: Translational Neurodegeneration 2017 6:10

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  29. Content type: Review

    Two centuries ago in 1817, James Parkinson provided the first medical description of Parkinson’s disease, later refined by Jean-Martin Charcot in the mid-to-late 19th century to include the atypical parkinsoni...

    Authors: Usman Saeed, Jordana Compagnone, Richard I. Aviv, Antonio P. Strafella, Sandra E. Black, Anthony E. Lang and Mario Masellis

    Citation: Translational Neurodegeneration 2017 6:8

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  30. Content type: Review

    A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse. Therapeutic options are currently...

    Authors: Patrick Sweeney, Hyunsun Park, Marc Baumann, John Dunlop, Judith Frydman, Ron Kopito, Alexander McCampbell, Gabrielle Leblanc, Anjli Venkateswaran, Antti Nurmi and Robert Hodgson

    Citation: Translational Neurodegeneration 2017 6:6

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  31. Content type: Research

    It is increasingly clear that in addition to myelin disruption, axonal degeneration may also represent a key pathology in multiple sclerosis (MS). Hence, elucidating the mechanisms of axonal degeneration may n...

    Authors: Gary Leung, Melissa Tully, Jonathan Tang, Shengxi Wu and Riyi Shi

    Citation: Translational Neurodegeneration 2017 6:5

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  32. Content type: Review

    Neurodegeneration of Parkinson’s disease (PD) starts in an insidious manner, 30–50% of dopaminergic neurons have been lost in the substantia nigra before clinical diagnosis. Prodromal stage of the disease, dur...

    Authors: Shu-Ying Liu, Piu Chan and A. Jon Stoessl

    Citation: Translational Neurodegeneration 2017 6:4

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  33. Content type: Review

    Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular componen...

    Authors: Tingting Xiao, Weiwei Zhang, Bin Jiao, Chu-Zheng Pan, Xixi Liu and Lu Shen

    Citation: Translational Neurodegeneration 2017 6:3

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  34. Content type: Review

    Alzheimer’s Disease (AD) is a global health issue given the increasing prevalence rate and the limitations of drug effects. As a consequent, non-pharmacological interventions are of importance. Music therapy (...

    Authors: Rong Fang, Shengxuan Ye, Jiangtao Huangfu and David P. Calimag

    Citation: Translational Neurodegeneration 2017 6:2

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  35. Content type: Review

    L-3, 4-Dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) is a major clinical complication in the treatment of Parkinson’s disease (PD). This debilitating side effect likely reflects aberrant compensator...

    Authors: Jing Pan and Huaibin Cai

    Citation: Translational Neurodegeneration 2017 6:1

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  36. Content type: Case report

    Acute-onset neurodegenerative diseases in older patients are rare clinical cases, especially when the degeneration only affects specific regions of the nervous system. Several neurological disorders have been ...

    Authors: Alexander Schulz, Franziska Wagner, Martin Ungelenk, Ingo Kurth and Christoph Redecker

    Citation: Translational Neurodegeneration 2016 5:23

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  37. Content type: Research

    Diabetes is the most common metabolic disease with many chronic complications, and cognitive disorders are one of the common complications in patients with diabetes. Previous studies have showed that autophagy...

    Authors: Zhu-Fei Guan, Xiu-Ling Zhou, Xiao-Ming Zhang, Yu Zhang, Yan-Mei Wang, Qi-Lin Guo, Gang Ji, Guo-Feng Wu, Na-Na Wang, Hao Yang, Zhong-Yu Yu, Hou-Guang Zhou, Jing-Chun Guo and Ying-Chao Liu

    Citation: Translational Neurodegeneration 2016 5:22

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  38. Content type: Research

    Alzheimer’s disease (AD) is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe treatment ag...

    Authors: Bei Zhang, Qiongqiong Li, Xingkun Chu, Suya Sun and Shengdi Chen

    Citation: Translational Neurodegeneration 2016 5:21

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  39. Content type: Review

    Amyloid plaques are pathological hallmarks of Alzheimer’s Disease (AD) and biomarkers such as cerebrospinal fluid (CSF) β-amyloid 1–42 (Aβ1-42) and amyloid positron emission tomographic (PET) imaging are impor...

    Authors: Maowen Ba, Min Kong, Xiaofeng Li, Kok Pin Ng, Pedro Rosa-Neto and Serge Gauthier

    Citation: Translational Neurodegeneration 2016 5:20

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