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  1. Review

    Protein misfolding in neurodegenerative diseases: implications and strategies

    A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse. Therapeutic options are currently...

    Patrick Sweeney, Hyunsun Park, Marc Baumann, John Dunlop, Judith Frydman, Ron Kopito, Alexander McCampbell, Gabrielle Leblanc, Anjli Venkateswaran, Antti Nurmi and Robert Hodgson

    Translational Neurodegeneration 2017 6:6

    Published on: 13 March 2017

  2. Review

    The role of exosomes in the pathogenesis of Alzheimer’ disease

    Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular componen...

    Tingting Xiao, Weiwei Zhang, Bin Jiao, Chu-Zheng Pan, Xixi Liu and Lu Shen

    Translational Neurodegeneration 2017 6:3

    Published on: 2 February 2017

  3. Review

    Opioid system in L-DOPA-induced dyskinesia

    L-3, 4-Dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) is a major clinical complication in the treatment of Parkinson’s disease (PD). This debilitating side effect likely reflects aberrant compensator...

    Jing Pan and Huaibin Cai

    Translational Neurodegeneration 2017 6:1

    Published on: 17 January 2017

  4. Case report

    Stroke-like onset of brain stem degeneration presents with unique MRI sign and heterozygous NMNAT2 variant: a case report

    Acute-onset neurodegenerative diseases in older patients are rare clinical cases, especially when the degeneration only affects specific regions of the nervous system. Several neurological disorders have been ...

    Alexander Schulz, Franziska Wagner, Martin Ungelenk, Ingo Kurth and Christoph Redecker

    Translational Neurodegeneration 2016 5:23

    Published on: 27 December 2016

  5. Research

    Beclin-1- mediated autophagy may be involved in the elderly cognitive and affective disorders in streptozotocin-induced diabetic mice

    Diabetes is the most common metabolic disease with many chronic complications, and cognitive disorders are one of the common complications in patients with diabetes. Previous studies have showed that autophagy...

    Zhu-Fei Guan, Xiu-Ling Zhou, Xiao-Ming Zhang, Yu Zhang, Yan-Mei Wang, Qi-Lin Guo, Gang Ji, Guo-Feng Wu, Na-Na Wang, Hao Yang, Zhong-Yu Yu, Hou-Guang Zhou, Jing-Chun Guo and Ying-Chao Liu

    Translational Neurodegeneration 2016 5:22

    Published on: 12 December 2016

  6. Research

    Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β phosphorylation in a tau transgenic Drosophila model of Alzheimer’s disease

    Alzheimer’s disease (AD) is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe treatment ag...

    Bei Zhang, Qiongqiong Li, Xingkun Chu, Suya Sun and Shengdi Chen

    Translational Neurodegeneration 2016 5:21

    Published on: 29 November 2016

  7. Review

    The study of brain functional connectivity in Parkinson’s disease

    Parkinson’s disease (PD) is a neurodegenerative disorder primarily affecting the aging population. The neurophysiological mechanisms underlying parkinsonian symptoms remain unclear. PD affects extensive neural...

    Lin-lin Gao and Tao Wu

    Translational Neurodegeneration 2016 5:18

    Published on: 28 October 2016

  8. Review

    The biomarkers of immune dysregulation and inflammation response in Parkinson disease

    Parkinson’s disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histoco...

    Li Chen, Mingshu Mo, Guangning Li, Luan Cen, Lei Wei, Yousheng Xiao, Xiang Chen, Shaomin Li, Xinling Yang, Shaogang Qu and Pingyi Xu

    Translational Neurodegeneration 2016 5:16

    Published on: 26 August 2016

  9. Research

    The predictive value of SS-16 in clinically diagnosed Parkinson’s disease patients: comparison with 99mTc-TRODAT-1 SPECT scans

    Dopamine transporter based imaging has high diagnostic performance in distinguishing patients with Parkinson’s disease (PD) from patients with non-Parkinsonian syndromes. Our previous study indicated that the ...

    Wenyan Kang, Fangyi Dong, Dunhui Li, Thomas J. Quinn, Shengdi Chen and Jun Liu

    Translational Neurodegeneration 2016 5:15

    Published on: 20 August 2016

  10. Review

    Mitochondrial dysfunction in Parkinson’s disease

    Parkinson’s disease (PD) is the second most common neurodegenerative disease, which is characterized by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta and the formation of Lewy bodies ...

    Qingsong Hu and Guanghui Wang

    Translational Neurodegeneration 2016 5:14

    Published on: 22 July 2016

  11. Review

    The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease

    Parkinson’s disease (PD) is a chronic, progressive and debilitating disease, which affects over 2.5 million people in China. PD is characterized clinically by resting tremor, muscular rigidity, bradykinesia an...

    Shengdi Chen, Piu Chan, Shenggang Sun, Haibo Chen, Baorong Zhang, Weidong Le, Chunfeng Liu, Guoguang Peng, Beisha Tang, Lijuan Wang, Yan Cheng, Ming Shao, Zhenguo Liu, Zhenfu Wang, Xiaochun Chen, Mingwei Wang…

    Translational Neurodegeneration 2016 5:12

    Published on: 30 June 2016

  12. Review

    Meta-analysis of risk factors for Parkinson’s disease dementia

    Parkinson’s disease (PD) is a common heterogeneous neurodegenerative disorder in elder population. Parkinson’s disease dementia (PDD) is one of the most common non-motor manifestations in PD patients. No compr...

    Yaqian Xu, Jing Yang and Huifang Shang

    Translational Neurodegeneration 2016 5:11

    Published on: 1 June 2016

  13. Research

    Methylation status of DJ-1 in leukocyte DNA of Parkinson’s disease patients

    DJ-1 has been thought as a candidate biomarker for Parkinson’s disease (PD). It was found reduced in PD brains, CSF and saliva, although there were conflicting results. How DJ-1 expression may be regulated is ...

    Yuyan Tan, Li Wu, Dunhui Li, Xiaoli Liu, Jianqing Ding and Shengdi Chen

    Translational Neurodegeneration 2016 5:5

    Published on: 31 March 2016

  14. Research

    miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia – an exploratory study

    MicroRNAs (miRNAs) are small non-coding RNA molecules that function as posttranscriptional regulators of gene expression. Measurements of miRNAs in cerebrospinal fluid (CSF) and blood have just started gaining...

    Sofie Sølvsten Sørensen, Ann-Britt Nygaard and Thomas Christensen

    Translational Neurodegeneration 2016 5:6

    Published on: 15 March 2016

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