Figure 4
From: Biological function of Presenilin and its role in AD pathogenesis
Presenilin functions. This diagram divides the functions of presenilins into γ-secretase-dependent and γ-secretase-independent ones by the vertical dash line. The γ-secretase activity of presenilins are exemplified by APP processing and Notch processing. Other γ-secretase independent functions of presenilins include stabilizing β-catenin in Wnt signaling pathway, regulating calcium homeostasis and its interaction with synaptic transmission. APP, amyloid β precursor protein; AICD, APP intracellular domain; NICD, Notch intracellular domain; Nct, Nicastrin; IP3, Inositol trisphosphate receptor; SERCA, Sarco/endoplasmic reticulum Ca2+−ATPase; Ryan R, Ryanodine receptor; GSK, Glycogen synthase kinase.