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  1. Parkinson`s disease (PD) is a progressive, disabling neurodegenerative disorder with onset of motor and non-motor features. Both reduce quality of life of PD patients and cause caregiver burden. This review ai...

    Authors: Thomas Müller

    Citation: Translational Neurodegeneration 2012 1:10

    Content type: Review

    Published on:

  2. Amyloid-β-protein (Aβ), the key component of senile plaques in Alzheimer's disease (AD) brain, is produced from amyloid precursor protein (APP) by cleavage of β-secretase and then γ-secretase. APP adaptor prot...

    Authors: Zhongcong Xie, Yuanlin Dong, Uta Maeda, Weiming Xia and Rudolph E Tanzi

    Citation: Translational Neurodegeneration 2012 1:8

    Content type: Research

    Published on:

  3. Several studies indicated that Erythropoietin (Epo) may provide remarkable neuroprotection in some neurological diseases. It also showed the significant decrease of Epo immunoreactivity in the cerebral cortex and...

    Authors: Sun Zhi-Kun, Yang Hong-Qi, Wang Zhi-Quan, Pan Jing, Hong Zhen and Chen Sheng-Di

    Citation: Translational Neurodegeneration 2012 1:7

    Content type: Research

    Published on:

  4. This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson's disease (PD). Mitochondria provide cellular ener...

    Authors: Philip WL Ho, Jessica WM Ho, Hui-Fang Liu, Danny HF So, Zero HM Tse, Koon-Ho Chan, David B Ramsden and Shu-Leong Ho

    Citation: Translational Neurodegeneration 2012 1:3

    Content type: Review

    Published on:

  5. The A53T mutation in the α-synuclein gene causes autosomal-dominant Lewy body Parkinson's disease (PD). Cultured cell models have linked this mutation to increased cell macroautophagy, although evidence of enhanc...

    Authors: Yue Huang, Fariba Chegini, Germaine Chua, Karen Murphy, Weiping Gai and Glenda M Halliday

    Citation: Translational Neurodegeneration 2012 1:2

    Content type: Research

    Published on:

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