Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease

Jiang, Dongfang; Liu, Hongmei; Li, Tingting; Zhao, Song; Yang, Keyan; Yao, Fuwen; Zhou, Bo; Feng, Haiping; Wang, Sijia; Shen, Jiaqi; Tang, Jinglan; Zhang, Yu-Xin; Wang, Yun; Guo, Caixia; Tang, Tie-Shan

doi:10.1186/s40035-024-00414-z

Table 1 List of microRNAs predicted by miRWalk to bind with the 5’UTR of Cpe gene

From: Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease

Number	MicroRNA name	Sequence
Number	MicroRNA name	Sense (5’-3’)	Antisense (5’-3’)
m1	mmu-miR-7060-3p	UCUACUCUACCUUCUACUCAG	GAGUAGAAGGUAGAGUAGAUU
m2	mmu-miR-702-3p	UGCCCACCCUUUACCCCGCUCC	AGCGGGGUAAAGGGUGGGCAUU
m3	mmu-miR-7088-3p	UUGACCUUCCUCCAUUGCUUCC	AAGCAAUGGAGGAAGGUCAAUU
m4	mmu-miR-6896-3p	UUUCUCUCUCUCACCUACAAAC	UUGUAGGUGAGAGAGAGAAAUU
m5	mmu-miR-3059-5p	UUUCCUCUCUGCCCCAUAGGGU	CCUAUGGGGCAGAGAGGAAAUU
m6	mmu-miR-6917-3p	GUCACUUCUCUUCCCACCACAG	GUGGUGGGAAGAGAAGUGACUU
m7	mmu-miR-6963-3p	UGCCUCUUGCCUCCAUCCCACAG	GUGGGAUGGAGGCAAGAGGCAUU
m8	mmu-miR-6975-3p	UCUCUCCUUUCUCCUCCUAG	AGGAGGAGAAAGGAGAGAUU
m9	mmu-miR-7009-3p	UCUUUUCCCCUCUCCCUGCAG	GCAGGGAGAGGGGAAAAGAUU
m10	mmu-miR-7031-3p	AACCCUCUUGCCCUCUCCUAG	AGGAGAGGGCAAGAGGGUUUU
m11	mmu-miR-7032-3p	AUCCUCUCGGUACCGCCCUGCA	CAGGGCGGUACCGAGAGGAUUU
m12	mmu-miR-7650-5p	AAUCCUCUUGCAACCCAGAACU	UUCUGGGUUGCAAGAGGAUUUU
m13	mmu-miR-8112	UCUCCGCCACCUCCACCGCA	CGGUGGAGGUGGCGGAGAUU
m14	mmu-miR-1224-3p	CCCCACCUCUUCUCUCCUCAG	GAGGAGAGAAGAGGUGGGGUU
m15	mmu-miR-3099-5p	CCCCACCUCUUCUCUCCUCAG	GAGGAGAGAAGAGGUGGGGUU
m16	mmu-miR-6978-3p	ACGGCUUCACUCUCACCCUGCAG	GCAGGGUGAGAGUGAAGCCGUUU
m17	mmu-miR-7068-5p	GUGAGGCUCAGUAUGGGGUGG	ACCCCAUACUGAGCCUCACUU
m18	mmu-miR-7077-3p	CCUUCCAUGGCUCCUGGCAG	GCCAGGAGCCAUGGAAGGUU
m19	mmu-miR-7091-3p	AGUGGCUUCUGUCGUCUCUAG	AGAGACGACAGAAGCCACUUU
m20	mmu-miR-7220-5p	GGUGAGCUCUUGGUACCUUGGC	CAAGGUACCAAGAGCUCACCUU
m21	mmu-miR-7667-5p	GAGCCAUCUCUCUAGCCCCUGA	AGGGGCUAGAGAGAUGGCUCUU
m22	mmu-miR-7676-3p	UCCGGUGCUCACUCUGCCCACA	UGGGCAGAGUGAGCACCGGAUU
m23	mmu-miR-7012-3p	UGACCUGUGGCUCCUCUCCCAG	GGGAGAGGAGCCACAGGUCAUU
m24	mmu-miR-7022-3p	ACAAGCCUGACCUCUGCCCCCA	GGGGCAGAGGUCAGGCUUGUUU
m25	mmu-miR-7075-3p	CAACCAUGUCUUCUUUCCCAG	GGGAAAGAAGACAUGGUUGUU
m26	mmu-miR-7117-5p	UCUGGGGGCUCAGCUGAGGAUA	UCCUCAGCUGAGCCCCCAGAUU
m27	mmu-miR-185-3p	AGGGGCUGGCUUUCCUCUGGU	CAGAGGAAAGCCAGCCCCUUU
m28	mmu-miR-302c-5p	GCUUUAACAUGGGGUUACCUGC	AGGUAACCCCAUGUUAAAGCUU
m29	mmu-miR-1947-3p	GCACUGAGCUAGCUCUCCCUCC	AGGGAGAGCUAGCUCAGUGCUU
m30	mmu-miR-3076-3p	CGCACUCUGGUCUUCCCUUGCAG	GCAAGGGAAGACCAGAGUGCGUU
m31	mmu-miR-6990-3p	AGCCCUGCCUCUUCCUGGCAG	GCCAGGAAGAGGCAGGGCUUU
m32	mmu-miR-7005-5p	CCUGGGGAUGGGAGGACCAGCA	CUGGUCCUCCCAUCCCCAGGUU
m33	mmu-miR-7684-3p	UGCUGACUGGGGCUGGCCUGUG	CAGGCCAGCCCCAGUCAGCAUU
m34	mmu-miR-7686-3p	CUGCUCGGGGCACUGUAAGAGA	UCUUACAGUGCCCCGAGCAGUU
m35	mmu-miR-338-3p	UCCAGCAUCAGUGAUUUUGUUG	ACAAAAUCACUGAUGCUGGAUU
m36	mmu-miR-106a-3p	ACUGCAGUGCCAGCACUUCUUAC	AAGAAGUGCUGGCACUGCAGUUU
m37	mmu-miR-1982-5p	UUGGGAGGGUCCUGGGGAGG	UCCCCAGGACCCUCCCAAUU
m38	mmu-miR-3090-5p	GUCUGGGUGGGGCCUGAGAUC	UCUCAGGCCCCACCCAGACUU
m39	mmu-miR-6340	GUCAGCAGCAGCUUCGCUUUGGC	CAAAGCGAAGCUGCUGCUGACUU
m40	mmu-miR-6366	AGCUAAGGGGCCCGGGGAGCCA	GCUCCCCGGGCCCCUUAGCUUU
m41	mmu-miR-12182-5p	ACAGCGCCAGCUGCCUAAUUGA	AAUUAGGCAGCUGGCGCUGUUU
m42	mmu-miR-6982-5p	CUGGAGGAUCGCAGGGGUGGCCUGG	AGGCCACCCCUGCGAUCCUCCAGUU
m43	mmu-miR-6900-3p	UGGUGAUGGGCUCUCUUGUAG	ACAAGAGAGCCCAUCACCAUU
m44	mmu-miR-713	UGCACUGAAGGCACACAGC	UGUGUGCCUUCAGUGCAUU

The number, name and sequence of 44 microRNAs predicted by miRWalk to bind with the 5’UTR of Cpe gene are listed

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ISSN: 2047-9158

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