Fig. 5
From: LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression
LRRK2 kinase inhibition reduces cortical pathology in LRRK2G2019S mice. a Anatomic heatmaps of the mean regional tau pathology shown as log (% area occupied) at 6 MPI and second-generation P-values, calculated using ranked robust linear regression, of regional statistical significance of G2019S mice with 0 mg/kg MLi-2 compared to G2019S mice treated with 75 or 450 mg/kg MLi-2 (δP = 0). Tau pathology was not quantified in white matter regions, so they are plotted as gray. Analyzed regions shown below are outlined. NDB: diagonal band nucleus; AUDpo: posterior auditory area; RSPd: retrosplenial area, dorsal part; VISl: lateral visual area. b Representative images of selected regional tau pathology. Scale bar = 50 μm. c Quantification of selected brain regions. Regional tau shown as log (% area occupied). ns = not significant (δP ≠ 0), *: significant (δP = 0). N = 6 (0 mg/kg MLi-2), 4 (75 mg/kg MLi-2), or 7 (450 mg/kg MLi-2)