Fig. 4
From: LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression
LRRK2 kinase inhibition shows no protective effect in wild-type mice. a Anatomic heatmaps of the mean regional tau pathology shown as log (% area occupied) at 6 MPI and second-generation P-values of regional statistical significance, calculated using ranged robust linear regression, of WT mice with 0 mg/kg MLi-2 compared to wild-type mice treated with 75 or 450 mg/kg MLi-2 (δP = 0). Tau pathology was not quantified in white matter regions, so they are plotted as gray. Analyzed regions shown below are outlined. NDB: diagonal band nucleus; SI: substantia innominata; SSp-tr: primary somatosensory area, trunk; VISl: lateral visual area. b Representative images of selected regional tau pathology. Scale bar, 50 μm. c Quantification of selected brain regions. Regional tau shown as log (% area occupied). ns = not significant (δP ≠ 0), *: Significant (δP = 0). N = 7 (0 mg/kg MLi-2), 8 (75 mg/kg MLi-2), or 6 (450 mg/kg MLi-2)