Fig. 3
From: LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression
LRRK2G2019S mice show time-dependent alterations in cortical pathology. a Anatomic heatmaps of the mean regional tau pathology (AT8, pS202/T205 tau) shown as log (% area occupied) at 6 MPI and second-generation P-values, calculated using ranged robust linear regression, of regional statistical significance of wild-type mice compared to G2019S mice (δP = 0). Tau pathology was not quantified in white matter regions, so they are plotted as gray. Analyzed regions shown below are outlined. NDB: diagonal band nucleus; ENTl: entorhinal area, lateral part; SSp-m: primary somatosensory area, mouth; VISl: lateral visual area. b Representative images of selected regional tau pathology. Scale bar = 50 μm. c Quantification of selected brain regions. Regional tau shown as log (% area occupied). ns = not significant (δP ≠ 0); *: significant (δP = 0). N = 7 (WT) and 6 (G2019S)