Fig. 4
From: Emerging role of senescent microglia in brain aging-related neurodegenerative diseases
Promising strategies for microglia-targeted senotherapy. a Senolysis: Healthy and senescent microglia coexist in the aging brain, and senolysis targets and removes only the senescent microglia. b Infusion of youthful factor: To restore cognitive function in old mice, cerebrospinal fluid or plasma from young mice was administered. Further research is needed to determine which factors in the young mice reverse aging. c Restoration of microglial function: Microglial rejuvenation can be achieved by restoring the function of senescent microglia, revitalizing metabolism, and inhibiting inflammaging. Further research is needed. Created with Biorender.com