Fig. 2

Previously reported microglial subpopulations may share features with senescent microglia. Microglia in the neurodegenerative brain can be classified into distinct phenotypes: disease-associated microglia (DAM) and neurodegenerative microglia (MGnD). In the aged brain, microglia exhibit senescent features and accumulate lipid droplets (LDAM). Previous studies suggest that senescent microglia contribute to the pathophysiology of neurodegeneration, as the gene expression patterns of previously reported microglia overlap with those of senescent microglia. Created with Biorender.com