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Table 2 Correlations of LC noradrenergic cell density and fiber load with DBH+ load in the DLPFC and M1

From: Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer’s disease and Parkinson’s disease

 

DLPFC DBH+ load (%)

Pearson's r

P value

AD combined with controls

LC NA cell density (counts/mm2)

 − 0.515

0,036*

LC NA fiber load (%)

 − 0,036

0,454

AD

LC NA cell density (counts/mm2)

 − 0.406

0.212

LC NA fiber load (%)

0.028

0.479

 

M1 DBH+ load (%)

Pearson's r

P value

PD combined with controls

LC NA cell density (counts/mm2)

0.468

0.063

LC NA fiber load (%)

0.376

0.114

PD

LC NA cell density (counts/mm2)

 − 0.157

0.332

LC NA fiber load (%)

0.498

0.071

  1. AD Alzheimer’s disease, PD Parkinson’s disease, LC locus coeruleus, NA noradrenergic, DBH dopamine-beta hydroxylase, DLPFC dorsolateral prefrontal cortex, M1 primary motor cortex