Table 1 Demographics, clinical, radiological and pathological characteristics of included cohort
Control | AD | PD | |
|---|---|---|---|
Clinical characteristics | |||
Number of cases | 8 | 9 | 14 (8 PD and 6 PDD) |
Sex, male/female (%male) | 5/3 (63%) | 7/2 (78%) | 10/4 (71%) |
Age at death, years | 73 ± 11 (range 57–85) | 64 ± 10 (53–84)# | 75 ± 6 (62–90) |
Disease duration, years | − | 9 ± 6# | 15 ± 4 |
Post-mortem delay (h:min) | 7:18 ± 2:14 | 8:12 ± 0:58 | 7:06 ± 1:52 |
Radiological characteristics | |||
Normalized brain volume (ml) | 1468.7 ± 69.1 | 1391.8 ± 132.4 | 1417.9 ± 90.1 |
Normalized grey matter volume (ml) | 732.4 ± 52.9 | 649.2 ± 64.6*,# | 700.6 ± 47.0 |
Normalized white matter volume (ml) | 736.4 ± 37.8 | 742.7 ± 105.8 | 717.4 ± 73.5 |
Pathological characteristics | |||
Thal phase (n) | 8 | 9**,## | 14 |
0/1/2/3/4/5 | 1/6/0/0/1/0 | 0/0/0/1/4/4 | 0/7/3/4/0/0 |
Braak neurofibrillary tangle stage (n) | 8 | 9**,## | 14 |
0/I/II/III/IV/V/VI | 2/2/1/3/0/0/0 | 0/0/0/0/1/5/3 | 0/1/10/3/0/0/0 |
Braak Lewy body stage (n) | 8 | 9 | 14 |
0/1/2/3/4/5/6 | 8/0/0/0/0/0/0 | 9/0/0/0/0/0/0 | 0/0/0/0/0/0/14 |