Fig. 4

Noradrenergic innervation in the ACC, DLPFC, M1 and hippocampus. a PD showed a trend of reduced DBH⁺ load in the ACC compared to AD (P = 0.061, uncorrected), while no difference was found between AD and controls. b AD showed significantly increased DBH⁺ load in the DLPFC compared to both PD and control donors (respectively, P = 0.006 and P = 0.007, both FDR-corrected), while no difference was found between PD and controls. c PD showed reduced DBH⁺ load in the M1 compared to controls (P = 0.03, uncorrected), while no difference was found between AD and PD or between AD and controls. d No group differences in the DBH⁺ load in the hippocampus was found. Within the PD group, PD cases are labeled with darker blue, whereas PDD cases are labeled with lighter blue. Scale bar, 5 mm for all images. ^#P < 0.05, uncorrected; **P < 0.01, FDR-corrected