Fig. 5

CARS accumulates within dense-core Aβ plaques along with recruitment of ameboid microglia in the post-mortem temporal cortical tissues from AD patients. a Representative images showing CARS expression (green) within 4G8 (anti-β-amyloid antibody, red)-labeled diffusive Aβ plaques (upper panels) and dense-core Aβ plaques (lower panels) in the temporal cortical tissues from AD patients. The dashed lines indicate diffusive Aβ plaques (upper panels) and dense-core Aβ plaques (lower panels), and the magnifications are shown in the right panels. b Quantification of normalized CARS-ir intensity within the diffusive and the dense-core Aβ plaques in the temporal cortical tissues from three AD subjects. c Representative images showing Iba1-labeled microglia (red) within 4G8 (green)-labeled diffusive Aβ plaques (upper panels) and dense-core Aβ plaques (lower panels) in the temporal cortex of the AD subjects. d Quantification of microglia within the diffusive and the dense-core Aβ plaques in the temporal lobe cortex from three AD subjects. Data are shown as mean ± SEM; ****P < 0.0001