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Fig. 8 | Translational Neurodegeneration

Fig. 8

From: Supplementation with high-GABA-producing Lactobacillus plantarum L5 ameliorates essential tremor triggered by decreased gut bacteria-derived GABA

Fig. 8

L. plantarum L5 elevated the level of GABA in the cerebellum of ET mice. a Orthogonal partial least-squares discriminant analysis (OPLS-DA) score plot of cerebellar neurotransmitter levels. b The relative level of cerebellar GABA. c Heatmap showing the correlations between the cerebellar neurotransmitter levels and the parameters indicating ET severity. d Heatmap indicating the correlations between the cerebellar neurotransmitter levels and generic-level abundances of gut microbes. 5-HIAA, 5-hydroxyindole-3-acetic acid; 5-HT, serotonin hydrochloride; Ach, acetylcholine chloride; E, adrenaline hydrochloride; GABA, γ-aminobutyric acid; Gln, L-glutamine; Glu, L-glutamic acid; His, L-histidine; HisA, histamine; Kyn, DL-kynurenine; KynA, kynurenic acid; L5, L. plantarum L5; NE, noradrenaline hydrochloride; NS, normal saline; Trp, L-tryptophan; TrpA, tryptamine; Tyr, L-tyrosine; TyrA, tyramine; XA, xanthurenic acid. The box plots indicate the median and interquartile range. *P < 0.05; **P < 0.01; ***P < 0.001

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Translational Neurodegeneration

ISSN: 2047-9158

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