Fig. 2

Gut microbiota derived from patients with ET extended the duration of tremors and compromised mobility in mice models of ET. a Study design involving the transplantation of gut microbiota from ET patients and healthy controls into mice (three times per week for three weeks). b Representative activity trajectories of mice receiving fecal microbiota from ET patients and healthy controls. c-f Total distance covered (c), active duration in 5 min (d), duration of rotarod test (e), and tremor intensity score (f) of mice receiving gut microbiota from ET patients or healthy controls. g Tremor intensity score in mice before and after receiving intraperitoneal injection of harmaline. h Study design involving mice treated with gut microbiota from ET patients and healthy controls, followed by harmaline treatment to induce ET. i-k Duration of tremor (i), tremor intensity score (j), and representative activity trajectories (k) of mice receiving fecal microbiota from ET patients and healthy controls after harmaline injection. HC, healthy controls; ET, essential tremor; FMT, fecal microbiota transplantation. Data are presented as the mean ± standard deviation. ^*P < 0.05; ^**P < 0.01