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Fig. 7 | Translational Neurodegeneration

Fig. 7

From: Blockage of VEGF function by bevacizumab alleviates early-stage cerebrovascular dysfunction and improves cognitive function in a mouse model of Alzheimer’s disease

Fig. 7

The levels of proteins associated with the blood–brain barrier in the hippocampus of 5×FAD mice. (a) Representative images and (b) quantitative analysis of Cgn, ZO-1, and claudin 5 protein levels in the hippocampus of female 5×FAD mice (n = 7–10 mice per group). (c) Representative images and (d) quantitative analysis of Cgn, ZO-1, and claudin 5 protein levels in the hippocampus of male 5×FAD mice (n = 8–10 mice per group). All data are presented as the mean ± SEM and were analyzed by one-way ANOVA followed by Fisher’s LSD test. WT (Veh): wild-type littermates receiving sham treatment, AD (Veh): 5×FAD mice receiving sham treatment, AD (Bev): 5×FAD mice receiving bevacizumab treatment. Cgn: cingulin, ZO-1: zonula occludens-1

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Translational Neurodegeneration

ISSN: 2047-9158

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