Table 2 Current therapeutic approaches targeting OPCs in AD mice
From: Oligodendrocyte progenitor cells in Alzheimer’s disease: from physiology to pathology
Therapeutic approach | Species | Target | Description | References |
|---|---|---|---|---|
Senolytic | APP/PS1 transgenic mice | Senescent OPCs | Utilizes compounds that can selectively clear senescent OPC | [18] |
Rejuvenation | Hemizygous hAPP-J20 mice | Senescent OPCs | Mitigates OPC aging by overexpressing anti-aging gene KLOTHO | [209] |
Promotion of cell differentiation | 3×Tg-AD mice | OPC differentiation-related pathways | Promotes OPC differentiation with RXR agonist | [216] |
APP/PS1 transgenic mice | Promotes OPC differentiation with mTOR inhibitor | [15] |