Oligodendrocyte progenitor cells in Alzheimer’s disease: from physiology to pathology

Table 1 Changes of OPC proliferation in AD mice

Animal models	Age/months	Sex	Proliferation	Brain area	References
APP/PS1 mice	3, 6, 9, 12, 15, and 18	Male, Female	–	Cortex	[152]
APP/PS1 mice	6, 8	N/A	↑	Cortical gray matter and white matter	[153]
APP/PS1 mice	2	N/A	↑	Hippocampus	[154]
APP/PS1 mice	6	Male	↑	Temporal cortices	[155]
APP/PS1 mice	12, 15	N/A	↑	Cortex	[88]
3×Tg-AD mice	24	Male	↓	Hippocampus	[17]

“↑” represents an increase, “↓” represents a decrease, and “–” represents no observed changes

ISSN: 2047-9158