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Fig. 5 | Translational Neurodegeneration

Fig. 5

From: Intranasal administration of induced pluripotent stem cell-derived cortical neural stem cell-secretome as a treatment option for Alzheimer’s disease

Fig. 5

Intranasal delivery of iPSC-derived CNSC-SE improved the excessive anti-inflammatory response. a Confocal images of GFAP immunostaining in the whole brains of 5×FAD (AD model mice) and CNSC-SE-treated 5×FAD mice. b Representative images of Aβ (6E10) plaques and astrocyte (GFAP) co-staining in the cortex of 5×FAD mice and CNSC-SE-treated 5×FAD mice. c Quantification of GFAP-positive astrocytes and internalized Aβ using the Image J software. Scale bars, 20 μm. iPSC, induced pluripotent stem cells; CNSC-SE, cortical neural stem cell secretome; GFAP, glial fibrillary acidic protein

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Translational Neurodegeneration

ISSN: 2047-9158

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