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Fig. 3 | Translational Neurodegeneration

Fig. 3

From: Intranasal administration of induced pluripotent stem cell-derived cortical neural stem cell-secretome as a treatment option for Alzheimer’s disease

Fig. 3

Intranasal delivery of iPSC-derived CNSC-SE significantly improved memory in AD mice. a Schematic image of injection schedule. b Intranasal delivery design: (1) wild-type mice as controls (WT group); (2) 5×FAD AD model (AD group, n = 4); (3) CNSC-SE-treated 5×FAD mice (n = 10); and (4) MSC-treated 5×FAD mice (n = 10). c Monitoring of improved memory by Barnes maze. d Track plots. Data are presented as mean ± SEM. One-way ANOVA; *P < 0.05; **P < 0.01; ***P < 0.001, Dunnett’s test. iPSC, induced pluripotent stem cells; MSC, mesenchymal stem cells; CNSC-SE, cortical neural stem cell secretome

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Translational Neurodegeneration

ISSN: 2047-9158

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