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Fig. 1 | Translational Neurodegeneration

Fig. 1

From: Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

Fig. 1

Mutant tau expression induces significant increases in nSMase2 activity and ceramide levels in cultured neurons. a nSMase2 activity from untransduced control (Ctrl), AAV-GFP-transduced, and AAV-hTau (P301L/S320F)-transduced cells. b Heat map of the significantly elevated ceramide species in AAV-hTau (P301L/S320F)-transduced cells compared to either control or AAV-GFP-transduced cells. Colors represent fold changes of relative abundance compared to untransduced control cell levels. Red indicates increased fold-change, blue represents decreased fold-change. c–i Individual levels of the altered ceramides. n = 4/group. Bars represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. One-way ANOVA with Tukey’s multiple comparison

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Translational Neurodegeneration

ISSN: 2047-9158

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