Fig. 3
From: Metabolic regulation of microglial phagocytosis: Implications for Alzheimer's disease therapeutics
Effects of specific nutrients on microglial functions in the context of neurodegeneration. A detrimental microglial phenotype is characterized by increased production of inflammatory cytokines, enhanced glucose uptake, increased glycolysis, and reduced OXPHOS. Similar effects are likely induced by SFAs. In contrast, a beneficial phenotype of microglia is characterized by upregulation of microglial phagocytosis and repair mechanisms without a substantial increase in inflammatory cytokines. Those functions are associated with increased OXPHOS, as well as supplementation with PUFAs, ketone bodies, lactate and pyruvate