Fig. 3
From: NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors
Schematic diagram of the effects of NLRP3 on glial activation. Hypoxia can cause brain damage [91], which leads to microglial activation and infiltration [100]. In this process, NLRP3 inflammasome is involved in the activation of microglia and the release of inflammatory factors. Inhibition of NLRP3 inflammasome activation can reduce neuroinflammation caused by brain injury and improve neurological function [99]