Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis

Table 1 Twenty pathways most associated with the top 500 genes of ALS and muscular atrophy

Pathways	ALS		Muscular atrophy		Geneset
Pathways	Genes	adjP	Genes	adjP	Geneset
Signaling by interleukins	87	5.84E−33	79	5.59E−28	472
Interleukin-4 and interleukin-13 signaling	42	8.06E−29	43	1.90E−30	108
Autophagy	32	4.70E−13	28	1.29E−10	149
Selective autophagy	24	4.70E−13	20	6.80E−10	80
Interleukin-10 signaling	19	6.14E−13	13	3.75E−07	47
Macroautophagy	30	6.14E−13	26	3.40E−10	134
Programmed cell death	37	7.69E−13	35	6.37E−12	208
FOXO-mediated transcription	20	3.22E−11	27	2.02E−19	65
Cellular response to chemical stress	33	7.08E−11	34	4.85E−12	194
Apoptosis	30	1.11E−09	29	1.52E−09	179
Regulated necrosis	17	1.93E−09	14	4.14E−07	56
Purinergic signaling in leishmaniasis	12	5.19E−09	9	4.81E−06	26
Cell recruitment (proinflammatory)	12	5.19E−09	9	4.81E−06	26
PINK1-PRKN-mediated mitophagy	11	1.03E−08	10	1.01E−07	22
Mitophagy	12	2.17E−08	11	1.49E−07	29
Defective intrinsic pathway for apoptosis	11	5.08E−08	12	1.52E−09	25
TRIF(TICAM1)-mediated TLR4 signaling	21	5.08E−08	16	3.00E−05	108
MyD88-independent TLR4 cascade	21	5.08E−08	16	3.00E−05	108
Post NMDA receptor activation events	18	6.62E−08	8	0.036	80
Diseases of signaling by growth factor receptors and 2nd messengers	45	7.91E−08	61	2.85E−17	433

adjP, adjusted P value; Genes, number of mechanism-relevant genes among the ALS and muscular atrophy top 500 genes; Geneset, total number of genes associated with the pathway

ISSN: 2047-9158