Fig. 4
From: Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis
Self-perpetuating positive feedback loops contributing to mitochondrial deficiency in ALS. Two interacting and self-perpetuating feedback loops are envisaged: ROS-mediated protein aggregation which reduces the ETC resulting in further ROS, and ROS-induced mitoSTAT3 depletion which causes a reduction in the ETC thereby preventing mitoSTAT3 restoration. Note that impaired mitochondrial function leads to increased ROS