Fig. 2From: Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challengesNew pathogenic insights from monkey models expressing mutant TDP-43. TDP-43 remains in the nucleus of rodent neurons to elicit nuclear toxicity. In the primate neurons, however, the primate-specific caspase-4 cleaves TDP-43 to produce truncated TDP-43, which redistributes in the cytoplasm, resulting in cytoplasmic toxicityBack to article page