Fig. 1

Altered CSF proteins between Parkinson’s disease (PD) and Controls. a Volcano plot showing log2 fold change and -log10 adjusted P-value in the Stockholm cohort (n = 69 for controls; n = 81 for PD). b Forest plot displaying all significant proteins with log fold change and 95% confidence interval ordered in ascending adjusted P-values in the Stockholm cohort. c Boxplots of the top 4 most significant proteins in the Stockholm cohort, adjusted for age and sex; levels representing normalised protein expression (NPX) and P-values displayed. T-test for groupwise comparisons (n = 69 for controls; n = 81 for PD). d Receiver operating characteristic (ROC) curves for the top 4 proteins in the Stockholm cohort with areas under curve (AUC). e Volcano plot showing log2 fold change and -log10-adjusted P-value in the BioFIND cohort (n = 37 for controls; n = 51 for PD). f Forest plot displaying all significant proteins with log fold change and 95% confidence interval ordered in ascending adjusted P-values in the BioFIND cohort. g A forest plot comparing overlapping significant proteins