Fig. 8
From: α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis
A schematic image showing α-syn-carrying astrocyte-derived EVs (AEVs) in Parkinson’s disease (PD) versus in healthy control. Pathological α-syn deposition could increase EV secretion by astrocytes, possibly through α-syn-induced lysosomal dysfunction. The α-syn-containing AEVs in peripheral blood may be an effective biomarker for clinical diagnosis or differential diagnosis of PD