Fig. 7
From: α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis
Flow cytometric analysis of astrocyte-derived EVs in the clinical cohort. a The number of GLT-1+ EVs was significantly higher in PD than in MSA or HC. b The number of SYN211+ EVs was significantly higher in PD than in MSA or HC. c The number of MJFR14+ EVs was significantly higher in PD than in HC. d The number of GLT-1+/SYN211+ EVs was significantly higher in PD than in MSA or HC. e The number of GLT-1+/ MJFR14+ EVs was significantly higher in PD and MSA than in HC. N = 32 in MSA group and 34 in PD group. f ROC curves showing the separation of PD from HC using EVs carrying GLT-1, α-syn, and α-syn aggregates. g ROC curves showing separation of PD from MSA using EVs carrying GLT-1, α-syn, and α-syn aggregates. h An integrative model including all EV markers distinguishes PD from HC. i An integrative model including all EV markers distinguishes PD from MSA. N = 103 in the HC group, 106 in the PD group, and 47 in the MSA group. Values are means ± S.E.M., one-way ANOVA followed by a Tukey’s post-hoc test. *P < 0.05; **P < 0.01; ***P < 0.005