Multidimensional biomarkers for multiple system atrophy: an update and future directions

Wan, Linlin; Zhu, Sudan; Chen, Zhao; Qiu, Rong; Tang, Beisha; Jiang, Hong

doi:10.1186/s40035-023-00370-0

Translational Neurodegeneration

Table 1 Potential fluid protein and metabolite biomarkers for MSA

From: Multidimensional biomarkers for multiple system atrophy: an update and future directions

Biomarker	Fluid	Method	MSA versus HC (cohorts)	MSA versus PD (cohorts)	References
T-α-syn	CSF	ELISA BBMA	Decreased (Sweden cohort, UK cohort, Germany cohort, US cohort) Increased (UK cohort) No difference (Netherlands cohort, Japan cohort)	No difference (Germany cohort, US cohort, UK cohort, Netherlands cohort, Japan cohort)	[15,16,17,18,19,20,21, 23,24,25,26]
T-α-syn	Blood	ELISA	Increased (China cohort, South Korea cohort) No difference (Germany cohort)	Decreased (South Korea cohort) No difference (Germany cohort)	[17, 31, 32]
PS129-α-syn	CSF	ELISA BBMA	Decreased (US cohort) No difference (UK cohort)	Decreased (US cohort) No difference (UK cohort, Greece cohort)	[14, 20, 26]
PS129-α-syn	RBC	ELISA	Increased (Chinese cohort)	NA	[35]
O-α-syn	CSF	ELISA	No difference (UK cohort)	No difference (UK cohort)	[26]
O-α-syn	RBC	ELISA	Increased (Chinese cohort)	No difference (Chinese cohort)	[33, 34]
CoQ10	CSF	ELISA	Decreased (Spain cohort)	Decreased (Spain cohort)	[59]
CoQ10	Blood	UPLC-MS HPLC	Decreased (China cohort, Japan cohort)	No difference (China cohort, Japan cohort)	[60,61,62]
NfL	CSF	ELISA SIMOA	Increased (UK cohort, Germany cohort, Sweden cohort, Netherlands cohort, France cohort, Spain cohort, Russia cohort)	Increased (UK cohort, Germany cohort, Sweden cohort, Netherlands cohort)	[16, 21, 71,72,73,74]
NfL	Blood	SIMOA	Increased (UK cohort, Sweden cohort, France cohort, Spain cohort, Germany cohort, Russia cohort, Netherlands cohort)	Increased (UK cohort, Sweden cohort, Netherlands cohort)	[66, 73, 74]
YKL-40	CSF	ELISA	Increased (UK cohort) No difference (Sweden cohort)	Increased (Sweden cohort) No difference (UK cohort)	[16, 79, 80]
YKL-40	Blood	ELISA	No difference (Sweden cohort)	No difference (Sweden cohort)	[80]
GFAP	CSF	ELISA SIMOA	No difference (US cohort, Germany cohort, Netherlands cohort)	Increased (Germany cohort) No difference (Netherlands cohort)	[82,83,84]
MBP	CSF	ELISA	Increased (Netherlands cohort)	Increased (Netherlands cohort)	[84, 87]
Hcy	Blood	SPCEI	Increased (China cohorts)	Increased (male) (China cohorts)	[96,97,98,99]

BBMA bead-based multianalyte assay, CoQ10 coenzyme Q10, CSF cerebrospinal fluid, ELISA enzyme-linked immunosorbent assay, GFAP glial fibrillary acidic protein, HC healthy control, Hcy homocysteine, HPLC high-performance liquid chromatography, MBP myelin basic protein, MSA multiple system atrophy, NA not available, NfL neurofilament light protein, O-α-syn oligomeric α-synuclein, PS129–α-syn serine 129 phosphorylated α-synuclein, SIMOA single molecular array, SPCEI solid-phase competitive chemiluminescent enzyme immunoassay, T-α-syn total α-synuclein, UPLC-MS ultra-performance liquid chromatography coupled with mass spectrometer

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ISSN: 2047-9158

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