Impact of seed amplification assay and surface-enhanced Raman spectroscopy combined approach on the clinical diagnosis of Alzheimer’s disease

Table 1 Demographic, laboratory and neuropsychological data

Patient code	Clinical diagnosis	Age at CSF collection (years)	p-tau (pg/ml) *	t-tau (pg/ml) **	Aβ_1-42 (pg/ml) ***	Aβ_1-40 (pg/ml) ****	Aβ_1-42/Aβ_1-40 *****	MMSE score
AD#1	AD	63	56	452	694	n.a	n.a	22/30
AD#2	AD	58	98	1195	464	n.a	n.a	21/30
AD#3	AD	65	114	761	477	n.a	n.a	21/30
AD#4	AD	54	138	1133	349	9376	0.037	n.a
AD#5	AD	57	74	513	267	4661	0.057	12/30
AD#6	AD	49	64	427	525	n.a	n.a	26/30
AD#7	MCI-AD	52	72	451	575	n.a	n.a	28/30
AD#8	AD	75	79	779	464	n.a	n.a	23/30
AD#9	AD	63	52	404	483	n.a	n.a	n.a
AD#10	AD	75	179	1434	436	n.a	n.a	26/30
AD#11	AD	62	58	430	246	4603	0.053	21/30
AD#12	AD	77	94	855	314	6581	0.048	20/30
AD#13	MCI-AD	75	115	1130	440	8292	0.053	28/30
AD#14	MCI-AD	79	93	905	394	7536	0.052	28/30
AD#15	AD	70	60.1	396	230	4095	0.056	18/30
AD#16	AD	69	214.6	1258	261	7875	0.033	24/30
AD#17	AD	70	181.5	1211	577	10,190	0.057	24/30
AD#18	AD	74	239	1387	218	3839	0.057	26/30
AD#19	AD	74	93.2	610	434	9355	0.046	22/30
AD#20	MCI-AD	84	93.1	469	361	9005	0.040	29/30
ONC#1	PSP	71	46	278	460	7750	0.046	n.a
ONC#2	PD	58	24.1	131	592	6333	0.094	n.a
ONC#3	HyC	77	29	229	801	9760	0.082	n.a
ONC#4	HyC	71	28.7	163	594	7499	0.079	n.a
ONC#5	HyC	75	12.7	95	147	2090	0.070	n.a
ONC#6	HyC	78	54.4	299	645	10,337	0.062	n.a
ONC#7	HyC	75	21.7	136	267	4150	0.064	n.a
ONC#8	HyC	44	19.1	77	382	4374	0.087	n.a
ONC#9	HyC	63	n.a	n.a	163	1771	0.090	n.a
ONC#10	HyC	74	20.1	144	461	5149	0.090	n.a
ONC#11	HyC	59	26	138	1296	8101	0.160	n.a

*Measured with the INNOTEST® PHOSPHO-TAU (181P). Normal reference value < 61 pg/ml [50]
**Measured with the INNOTEST® hTAU Ag. Normal reference values: < 300 pg/ml, 21–50 years; < 400 pg/ml, 51–70 years; < 500 pg/ml, 71–93 years [51]
***Measured with the Lumipulse® G β-Amyloid 1–42. Normal reference value > 640 pg/ml [52]
****Measured with the Lumipulse® G β-Amyloid 1–40. Normal reference value range 7755–16,715 pg/ml [52]
***** Normal reference value range 0.068–0.115. Lower levels may be indicative or predictive of AD pathology [53]
n.a.: not available

ISSN: 2047-9158