Head-to-head comparison of plasma and PET imaging ATN markers in subjects with cognitive complaints

Table 2 Region-level reciprocal associations between plasma and PET imaging ATN biomarkers

	A Aβ₄₂/Aβ₄₀ ratio		T p-tau181, pg/ml		N t-tau, pg/ml		N NfL, pg/ml
	r	P	r	P	r	P	r	P
Entire cohort (n = 137)
A: Global SUVR	− 0.044	0.617	0.528	< 0.001***	0.039	0.653	0.036	0.679
T: MTL SUVR	− 0.018	0.836	0.613	< 0.001***	0.078	0.373	0.172	0.046
T: NEO-T SUVR	− 0.035	0.686	0.623	< 0.001***	0.081	0.350	0.204	0.018
N: metaROI SUVR	0.026	0.767	− 0.491	< 0.001***	− 0.013	0.885	− 0.189	0.029
Aβ+ (n = 90)
A: Global SUVR	0.070	0.520	0.143	0.186	− 0.046	0.669	− 0.044	0.683
T: MTL SUVR	0.122	0.259	0.254	0.018	− 0.047	0.665	0.063	0.563
T: NEO-T SUVR	0.123	0.257	0.274	0.010	− 0.043	0.693	0.142	0.188
N: metaROI SUVR	− 0.146	0.178	− 0.217	0.043	0.171	0.112	− 0.042	0.700
Aβ− (n = 47)
A: Global SUVR	0.187	0.223	0.242	0.113	− 0.094	0.545	− 0.260	0.089
T: MTL SUVR	0.324	0.032	0.362	0.016	− 0.108	0.484	0.090	0.561
T: NEO-T SUVR	0.220	0.151	0.380	0.011	− 0.102	0.509	0.062	0.691
N: metaROI SUVR	− 0.013	0.931	-0.033	0.831	0.032	0.838	− 0.239	0.118

Partial correction analysis adjusted for age, sex, and the interval from PET imaging to blood collection was undertaken to assess the reciprocal associations between plasma and PET imaging ATN biomarkers. The reported P values are unadjusted. Significant P values (P < 0.05) are marked in bold, those surviving multiple comparisons (Bonferroni’s correction) are marked with asterisks (***, P_c < 0.001)
PET Positron emission tomography, A/T/N Amyloid/Tau/Neurodegeneration, SUVR Standardized uptake value ratio, MTL Medial temporal lobe, NEO-T Temporal neocortex, metaROI Meta-analytically derived region of interest, t-tau Total tau, NfL Neurofilament light chain

ISSN: 2047-9158