Fig. 1
From: Perivascular spaces relate to the course and cognition of Huntington’s disease
Perivascular space (PVS) distribution in HTT mutation-carriers and its associations with brain atrophy and cognitive decline. a, b Performance of automatic segmentation of PVS on T2-weighted axial images in the deep white matter and basal ganglia (BG). c, d Correlations of global-brain PVS volume proportion (global-pPVS) and BG PVS volume proportion (BG-pPVS) with age in controls and HTT mutation-carriers. e, f Group comparisons of global-pPVS and BG-pPVS between control, pre-HD and HD groups. Box plots show median and interquartile range (IQR), and whiskers are data within 1.5 IQR of the median. A multiple linear regression was used for group comparison to control for the effect of age. g, h Correlations of BG-pPVS with caudate and putamen volumes after age adjustment. i, j Correlations of BG-pPVS with Stroop Word Reading Test and Symbol Digit Modality Test scores after age adjustment