Table 3 Animal studies on ELA and Alzheimer’s disease
From: Early life adversity as a risk factor for cognitive impairment and Alzheimer’s disease
ELA model | Species/sex | Period of exposure | Time of outcome measurement | Cognitive outcome/AD pathology | References |
|---|---|---|---|---|---|
MS | Wistar rats/male | PND 2–21 | Adulthood | Cognitive outcome↓ AD pathology↑ | [82] |
LBN | APPswe/PS1dE9 mice/male | PND 2–9 | 4 and 10 months of age | At 10 months of age, AD pathology↑ | [76] |
MS | APPswe/PS1dE9 mice/male | PND 2–21 | 9 months of age | Cognitive outcome↓ AD pathology↑ | [80] |
LBN | APPswe/PS1dE9 mice/male | PND 2–9 | 6 and 9 months of age | Cognitive outcome↓ AD pathology↑ | [78] |
LBN | APPswe/PS1dE9 mice/male | PND 2–9 | 6 and 12 months of age | Cognitive outcome↓ AD pathology↑ | [79] |
LBN | APPswe/PS1dE9 mice/male | PND 2–9 | 4 and 10 months of age | AD pathology↑ | [77] |
MS | AppNL−G−F mice/male | PND 2–15 | 1.5 and 4 months of age | Cognitive outcome↓ AD pathology↑ | [81] |