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Fig. 5 | Translational Neurodegeneration

Fig. 5

From: Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients

Fig. 5

Loss of dopaminergic ChAT contacts in PD. a–h Immunostaining against tyrosine hydroxylase (TH, red) and choline acetyltransferase (ChAT, green) in retinal sections of control (a, c) and PD (b, d) patients, and details of dopaminergic-ChAT connections (arrowheads) in control (e, f) and PD (g, h) retinas. i–k Quantification of the total number of DA-ChAT connections (i), the number of DA-ChAT connections in S1/S2 (j) and S3/S4 (k) strata of the IPL at 1, 3, 5, 7, 9 mm temporal from the optic nerve in control (n = 4) and PD retinas (n = 5). Two-way ANOVA with Sidak's multiple-comparison test. *P < 0.05, **P < 0.01, ***P < 0.001. ON: optic nerve. Scale bars: 20 μm (a–d). 10 μm (e–h)

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Translational Neurodegeneration

ISSN: 2047-9158

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