Fig. 4
From: Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine
Potential therapeutic strategies targeting fatty acids. Upper panel shows an overview of fatty acid metabolism intervention points with neuroprotective effects. Fatty acids and derivatives shown to be toxic in ALS are highlighted in salmon pink. Lower panels describe the toxicity and the therapeutic strategies used in ALS mice and ALS patients. a Inhibition of the switch to fatty acid β-oxidation, b COX- and LOX-mediated arachidonic acid toxicity, and c CB1/CB2 receptor activation-mediated neuroprotection. Intervening compounds are in orange