Table 2 Summary of candidate genes used in AD pathology
From: A review of brain imaging biomarker genomics in Alzheimer’s disease: implementation and perspectives
Year | Author | Dataset | Methods | Novel genes |
|---|---|---|---|---|
1991 [7] | Goate et al. | Gene Cloning | Molecular studies | APP gene |
1993 [10] | Corder et al. | Gene Cloning | Molecular studies | APOE gene |
1995 | Sherrington et al. | Gene Cloning | Molecular studies | 2 genes (PSEN1 and PSEN2) |
2009–2011 | Lambert et al. | GERAD EADI CHARGE ADGC | Meta-analysis | 11 genes (CLU, PICALM, CR1, BIN1, CD2AP, CD33, EPHA1, MS4A4A, ABCA7, MS4A6A, and MS4A4E) |
2013 [31] | Lambert et al. | IGAP (n = 74,046) | Meta-analysis | 11 genes (HLA-DRB5, SORL1, PTK2B, SLC24A4-RIN3, ZCWPW1, NME8, FERMT2, CELF1, INPP5D, MEF2C, and CASS4) |
2017 [32] | Sims et al. | IGAP (n = 85,133) | Meta-analysis | 3 genes (PLCG2, ABI3, and TREM2) |
2017 [33] | Liu et al. | UK Biobank (n = 116,196) | Meta-analysis | 4 genes (HBEGF, ECHDC3, SPPL2A, and SCIMP) |
2018 [34] | Marioni et al. | UK Biobank (n = 314,278) | Meta-analysis | 3 genes (ADAM10, KAT8, and ACE) |
2019 [21] | Jansen et al. | PGC-ALZ IGAP ADSP (n = 455,266) | Meta-analysis | 8 genes (ADAMTS4, HESX1, CLNK, CNTAP2, APH1B, ABI3, ALPK2, and ACO74212.3) |
2019 [20] | Kunkle et al. | IGAP (n = 94,437) | Meta-analysis | 5 genes (IQCK, ACE, ADAM10, ADAMTS1, and WWOX) |
2020 [24] | Schwartzentruber et al. | UK Biobank (n = 408,942) | Meta-analysis | 4 genes (CCDC6, TSPAN14, NCK2, and SPRED2) |
2021 [25] | Wightman et al. | 1,126,563 individuals | Meta-analysis | 7 genes (AGRN, TNIP1, TMEM106B, GRN, HAVCR2, NTN5, and LILRB2) |