Table 2 Treatment effects of modulation of furin expression on neurological diseases
From: The emerging role of furin in neurodegenerative and neuropsychiatric diseases
Disease | Model | Treatment | Targeted region | Furin expression | Effects | References |
|---|---|---|---|---|---|---|
AD | Tg2576 mice | Furin adenovirus | Cortex | Cortex ↑ | Reduces Aβ production by increasing α-secretase activity of ADAM10 and TACE | [13] |
|  | Furin-Tg mice | Brain-specific transgenic overexpression of furin | Brain | Brain ↑ | Elevates production of mBDNF, enhances dendritic spine density and promotes learning and memory | [26] |
AD | APP-C105 mice | Treadmill exercise | Whole body | Cortex ↑ | Increases furin expression, promoted APP cleavage by α-secretase, and attenuates AD-related symptoms | [23] |
AD | APP/PS1 mice | Gallic acid | Whole body | Brain ↑ | Increases furin expression, activates ADAM10, and reverses the loss of learning and memory | [338] |
AD | APP transgenic mice | Cerebrolysin | Hippocampus | Hippocampus ↑ | Increases furin and BDNF expression, improves survival of neural stem cell grafts and alleviates Aβ deposition | [339] |
PD | Paraquat-treated Drosophila | Transgenic knockdown of Fur1 | DA neurons | DA neurons ↓ | Protects DA neurons against the toxic effect of paraquat | [265] |
PD | Drosophila with LRRK2 overexpression | Disruption one allele of Fur1 | Whole body | Whole body ↓ | Reduces the retrograde synaptic enhancement induced by postsynaptic overexpression of LRRK2 | [266] |
PD | Drosophila with LRRK2 overexpression | Postsynaptic knockdown of Fur1 | Postsynaptic muscles | Neuromuscular junction ↓ | Reduces the retrograde synaptic enhancement induced by postsynaptic overexpression of LRRK2 | [266] |
Epilepsy | KA-induced epileptic mice; PTZ-kindled epileptic mice | Lentivirus containing sh-Furin | Hippocampus | Hippocampus ↓ | Reduces the spontaneous rhythmic electrical activity of cerebral neurons and suppresses epileptic seizure activity and severity | [25] |
Cerebral ischemia | Global ischemia rats | Monosialoganglioside; Flavanol epicatechin | Whole body | Hippocampus ↑ | Increases the levels of furin and NGF | [340] |