Table 1 Demographics, clinical characteristics and RT-QuIC results of PD patients who underwent NS and CSF sampling
Patients underwent NS at the AN (n = 46) | Patients underwent NS at the MT (n = 26) | P-value (effect size) | ||||
|---|---|---|---|---|---|---|
PD (n = 32) | Non-PD (n = 14) | PD (n = 11) | Non-PD (n = 15) | AN vs MT in PD | AN vs MT in non-PD | |
Age at diagnosis, years | 67 (60–70) | 73 (70–76) | 65 (53–70) | 68 (64–75) | 0.3 (R2 = .02) | 0.2 (R2 = 0.07) |
Sex Female/Male | 12/20 | 4/10 | 3/8 | 5/10 | 0.7 (φc = 0.09) | 0.9 (φc = 0.05) |
Age at onset, years | 66 (59–69) | 70 (61–74) | 64 (51–69) | 68 (63–71) | 0.4 (R2 = 0.02) | 0.4 (R2 = 0.02) |
Disease duration (from diagnosis), years | 2 (1–3) | ND | 2 (1–2) | ND | 0.9 (R2 = 0.00) | – |
Interval between clinical diagnosis and NS, months | 1 (1–8) | 12 (12–24) | 12 (2–12) | 12 (6–24) | 0.009 (R2 = 0.17)* | 0.9 (R2 = 0.00) |
Interval between lumbar puncture and NS, months | 1 (1–3) (n = 23) | 12 (1–18) (n = 8) | 2 (2–2) (n = 1) | 2 (2–12) (n = 11) | 0.6 (R2 = 0.04) | 0.7 (R2 = 0.01) |
MDS-UPDRS III score | 18 (11–33) | 5 (2–17) | 20 (12–31) | ND | 0.9 (R2 = 0.02) | – |
MoCA score | 27 (24–29) | 21 (19–24) | 25 (24–30) | ND | 0.5 (R2 = 0.01) | – |
Hyposmia n (%) | 17/32 (53) | ND | 5/11 (46) | ND | 0.7 (φc = 0.07) | – |
RT-QuIC-positive OM (%) | 27 (84) | 2 (14) | 5 (45) | 1 (7) | 0.018 (φc = 0.39)* | 0.6 (φc = 0.12) |
RT-QuIC-positive CSF (%) | 21/23 (91) | 1/8 (12) | 1/1 | 0/11 | 0.76 | 0.4 |