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Table 1 Age and genotype statistics for entorhinal cortical and hippocampal neuronal changes

From: Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer’s disease

Readout Age effect Genotype effect Age × genotype interaction 9-month: NTg vs Tg 12-month: NTg vs Tg 15-month: NTg vs Tg
EC NeuN
(Fig. 1c)
F(2,46) = 3.29;
*P = 0.05
F(1,46) = 0.20;
P = 0.66
F(2,46) = 0.55;
P = 0.58
N/A N/A N/A
EC layer II NeuN
(Fig. 1d)
F(2,46) = 25.10;
***P < 0.0001
F(1,46) = 4.81;
*P = 0.03
F(2,46) = 1.23;
P = 0.30
P = 0.06 P = 0.84 P = 0.43
HP NeuN
(Fig. 1e)
F(2,46) = 1.10;
P = 0.34
F(1,46) = 1.65;
P = 0.21
F(2,46) = 4.50;
*P = 0.02
P = 0.13 P = 0.13 P = 0.13
HP CA1 NeuN
(Fig. 1f)
F(2,46) = 0.96;
P = 0.39
F(1,46) = 0.008;
P = 0.93
F(2,46) = 4.48;
*P = 0.02
P = 0.92 P = 0.10 P = 0.10
HP CA3 NeuN
(Fig. 1g)
F(2,46) = 6.41;
**P = 0.004
F(1,46) = 6.28;
*P = 0.02
F(2,46) = 1.75;
P = 0.19
P = 0.06 P = 0.94 P = 0.09
HP GCL NeuN
(Fig. 1h)
F(2,46) = 3.35;
*P = 0.04
F(1,46) = 16.30;
***P = 0.0002
F(2,46) = 1.87;
P = 0.17
**P = 0.002 P = 0.36 *P = 0.04
  1. Two-way ANOVA with correction for multiple comparisons (genotype differences per age) with a Holm-Sidak post hoc test
  2. EC entorhinal cortex, GCL granular cell layer, HP hippocampus, NeuN neuronal nuclei, NTg non-transgenic, Tg transgenic
  3. Significant effects are in bold text. *P < 0.05; **P < 0.01; ***P < 0.001