Table 1 Age and genotype statistics for entorhinal cortical and hippocampal neuronal changes
Readout | Age effect | Genotype effect | Age × genotype interaction | 9-month: NTg vs Tg | 12-month: NTg vs Tg | 15-month: NTg vs Tg |
|---|---|---|---|---|---|---|
EC NeuN (Fig. 1c) | F(2,46) = 3.29; *P = 0.05 | F(1,46) = 0.20; P = 0.66 | F(2,46) = 0.55; P = 0.58 | N/A | N/A | N/A |
EC layer II NeuN (Fig. 1d) | F(2,46) = 25.10; ***P < 0.0001 | F(1,46) = 4.81; *P = 0.03 | F(2,46) = 1.23; P = 0.30 | P = 0.06 | P = 0.84 | P = 0.43 |
HP NeuN (Fig. 1e) | F(2,46) = 1.10; P = 0.34 | F(1,46) = 1.65; P = 0.21 | F(2,46) = 4.50; *P = 0.02 | P = 0.13 | P = 0.13 | P = 0.13 |
HP CA1 NeuN (Fig. 1f) | F(2,46) = 0.96; P = 0.39 | F(1,46) = 0.008; P = 0.93 | F(2,46) = 4.48; *P = 0.02 | P = 0.92 | P = 0.10 | P = 0.10 |
HP CA3 NeuN (Fig. 1g) | F(2,46) = 6.41; **P = 0.004 | F(1,46) = 6.28; *P = 0.02 | F(2,46) = 1.75; P = 0.19 | P = 0.06 | P = 0.94 | P = 0.09 |
HP GCL NeuN (Fig. 1h) | F(2,46) = 3.35; *P = 0.04 | F(1,46) = 16.30; ***P = 0.0002 | F(2,46) = 1.87; P = 0.17 | **P = 0.002 | P = 0.36 | *P = 0.04 |