Fig. 5

Post-mortem analyses revealed muscle atrophy and reduced telomere length in TDP-43 mice. a, b Although not reaching significance on the left-side, the right-side gastrocnemius muscles were significantly lighter in TDP-43 mice (n = 7) when compared to control mice (n = 5) at 3 weeks after the cessation of Dox feed. c TDP-43 mice also tended to have lighter spleens. d Telomere length was assessed using quantitative PCR on DNA extracted from ear tissue samples and found to be significantly shorter in TDP-43 mice (n = 6) when compared to control mice (n = 4). **P < 0.01, ***P < 0.001