Fig. 1

Motor performance is impaired in TDP-43 mice. a TDP-43 mice (n = 7) performed significantly worse in the rotarod task than their littermate controls (n = 5), which improved over time. Two-way ANOVA revealed a significant interaction between time and genotype (P < 0.0001), and a main effect of genotype with control mice running for significantly longer than TDP-43 mice (P < 0.0001). b Survival plot showing the percentage of mice not clasping at 1, 2 and 3 weeks post-Dox cessation. c The body weight of mice measured on the day of, and every two days after, the cessation of Dox feed. Two-way ANOVA demonstrated a significant interaction between genotype and time (P < 0.0001). Main effects of genotype are indicated by lines with asterisk between genotype symbols in figure legends. Significant results following Šídák’s multiple comparison testing are indicated by asterisk(s) at corresponding time points. *P < 0.05, **P < 0.01, ***P < 0.001