Fig. 1

STZ treatment reduces the body weight and induces more severe hyperglycemia in α-syn-overexpressing mice. (a) Schematic of the experimental design. Both WT and BAC-α-syn-GFP mice were injected (i.p.) with STZ or vehicle. Body weight and blood glucose level were routinely monitored throughout the experiment. The mice were subjected to behavioral tests at one month and three months after injections. (b) Percentage of survival at 12 weeks after STZ i.p. injections. (c, d) Body weight and blood glucose alterations after STZ i.p. injections. The number of mice per group was provided in Additional file 1: Table S1. ****P < 0.0001 α-syn + STZ versus α-syn + vehicle, ^####P < 0.0001 WT + STZ versus WT + vehicle, ^$P < 0.05 WT + STZ versus α-syn + STZ