Fig. 2
From: Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer’s disease
Distribution of secretory proteins in the control cerebral cortex. a Peroxidase immunohistochemistry shows distribution of representative secretory proteins (PC1/3, PC2, CPE, SgIII and CysC) in the CA1 region of the hippocampus. Scale bar, 20 μm. b Peroxidase immunohistochemistry and double confocal immunofluorescences illustrating SgIII (grey matter), CPE and CysC (white matter) in neocortical astrocytes. Arrowheads indicate glial soma and projections. Scale bars, 10 μm. c Double immunofluorescences of two different neocortical pyramidal neurons showing CysC colocalization with the lysosomal marker LAMP1, but not with the DCV cargo CPE. Scale bars, 5 μm