Table 2 Association of PRS, APOE ε4 status, hippocampal volume on MRI, and amyloid PET positivity with disease progression to dementia according to z-scores in all MCI participants, MCI with APOE ε4, and MCI without APOE ε4

PRS_+APOE

1.468 (1.335–1.615)

2.30 × 10^–15

1.167 (1.005–1.355)

4.16 × 10^–2

1.710 (1.244–2.351)

9.30 × 10^–4

PRS_−APOE

1.293 (1.157–1.445)

5.19 × 10^–6

1.172 (1.020–1.346)

2.47 × 10^–2

1.429 (1.182–1.728)

2.19 × 10^–4

APOE ε4 carrier status

2.678 (2.066–3.470)

9.70 × 10^–14†

NA

NA

Hippocampal volume on MRI

0.563 (0.502–0.632)

 < 2.00 × 10^–16*

0.538 (0.461–0.628)

3.55 × 10^–15†

0.536 (0.435–0.660)

4.44 × 10^–9††

Amyloid PET positivity

7.449 (4.199–13.215)

6.61 × 10^–12§

5.011 (1.966–12.764)

7.31 × 10^–4∥

6.500 (2.914–14.495)

4.77 × 10^–6¶